YB-1 (Human) antibody

Overview


	Antigen:	YB-1
	Antibody Type:	Monoclonal
	Application:	Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
	Reactivity:	Human
	Host:	Mouse
	Quantity:	25ug (Product variants)
	Price:	130,00 € (Plus shipping costs and VAT)
	Order number:	ABIN173290
	Availability:	1 day until shipment

Antigen	YB-1
Gene ID	4904
Immunogen	Recombinant YB-1
Reactivity	Human
Antibody Type	Monoclonal
Format	Affinity purified
Isotype	IgG2b »Matching secondary antibodies
Description	Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1.
Clone	F-E2G5
Host	Mouse

Application	Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Storage	Store aliquots at -20 C. Avoid repeated thawing and freezing
Research Area	Cancer
Restrictions	For Research Use only

Immunohistochemistry with paraffin-embedded sections using ABIN173290 (Rectum-Carcinoma)

Image for YB-1 (Human) antibody (1)

Immunohistochemistry with paraffin-embedded sections using ABIN173290 (Breast Cancer Metastasis)

Image for YB-1 (Human) antibody (2)

Immunohistochemistry with paraffin-embedded sections using ABIN173290 (Lung Cancer (Non-small cell.) )

Image for YB-1 (Human) antibody (3)

Google Scholar	Find more references for clone F-E2G5 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen YB-1 (Bioinformatic Harvester (EMBL))