Product details for  YB-1 (N-Term) (Human) antibody
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YB-1 (N-Term) (Human) antibody

Overview

Image for YB-1 (N-Term) (Human) antibody
Antigen: YB-1 (N-Term)
Antibody Type: Polyclonal
Application: Western Blotting (WB), Immunohistochemistry (IHC)
Reactivity: Human
Host: Rabbit
Quantity: 200ug (200ug/ml) (Product variants)
Price: 380,00 €   (Plus shipping costs and VAT)
Order number: ABIN155059
Availability: 1 day until shipment
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Additional Information:  YB-1 (N-Term) (Human) antibody

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Antigen YB-1 (N-Term)
Gene ID 4904
Reactivity Human
Antibody Type Polyclonal
Format Affinity purified
Isotype IgG »Matching secondary antibodies
Description Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1.
Host Rabbit

Application Details:  YB-1 (N-Term) (Human) antibody

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Application Western Blotting (WB), Immunohistochemistry (IHC)
Application Notes WB: 1:1000. IHC (p): 1:50 to 1:200 depending on type of tissue
Concentration 200ug/ml
Storage Store aliquots at -20 C. Avoid repeated thawing and freezing
Research Area Cancer
Restrictions For Research Use only

Publications:  YB-1 (N-Term) (Human) antibody

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Publications Krohn R, Raffetseder U, Bot I et al.:
"Y-Box Binding Protein-1 Controls CC Chemokine Ligand-5 (CCL5) Expression in Smooth Muscle Cells and Contributes to Neointima Formation in Atherosclerosis-Prone Mice"
In: Circulation , Vol. Epub ahead of print, 2007/10 (PubMed)

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Western Blot

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IHC

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External Information:  YB-1 (N-Term) (Human) antibody

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Google Scholar Find more references for antigen YB-1 (N-Term) on Google Scholar™
EMBL Harvester Search human, mouse or rat genome for antigen YB-1 (N-Term) (Bioinformatic Harvester (EMBL))