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Product details for alpha Synuclein (Human) antibody
alpha Synuclein (Human) antibody
Overview
| Antigen: | Alpha Synuclein |
| Antibody Type: | Monoclonal |
| Application: | Dot Blot (Dot), ELISA, Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 307,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN146096 |
| Availability: | 7 to 10 days until shipment |
Additional Information: alpha Synuclein (Human) antibody
| Antigen | Alpha Synuclein |
| Immunogen | Recombinant human alpha synuclein produced in E. coli. |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | The implication of alpha synuclein in neurodegenerative diseases started after the identification of non A beta component of amyloid (NAC peptide) in Alzheimer??s disease (AD) brains.There is now a general group of synucleinopathies which implicates alpha synuclein in Lewy body syndromes, Parkinson??s disease, and Alzheimer??s disease. Certain missense mutations in the alpha synuclein gene (A53T, A30P) have been linked to the familial Parkinson??s disease (PD). Alpha synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic PD, dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin.The expression is abundant in neurons and ty |
| Clone | 4B12 |
| Host | Mouse |
Application Details: alpha Synuclein (Human) antibody
| Application | Dot Blot (Dot), ELISA, Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Application Notes | Dot: Use at a dilution of 1/100-1/10000. ELISA: Use at an assay dependent dilution. IHC-P: Use at a dilution of 1/100-1/1000. Antigen retrieval is not essential but may optimise staining. IHC-Fr: Use at a dilution of 1/100-1/1000. WB: Use at a dilution of 1/100-1/10000. Predicted molecular weight: 16 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 1 mg/ml |
| Buffer | Preservative: 0.1% Sodium AzideConstituents: PBS |
| Restrictions | For research use only |
External Information: alpha Synuclein (Human) antibody
| Google Scholar | Find more references for clone 4B12 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen alpha Synuclein (Bioinformatic Harvester (EMBL)) |
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