c-Abl (phospho Y412) (Human) antibody

Übersicht

Antigen	C-Abl (phospho Y412)
Immunogen	The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more c
Reaktivität	Human, Mouse (Murine)
Antikörper-Typ	Polyklonal
Format	Liquid
Isotyp	IgG »Passende Sekundärantikörper
Beschreibung	C-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245.
Wirt	Rabbit

Applikation	Western Blotting (WB)
Applikationshinweise	WB: Use at a concentration of 0.1-1.0 ug/ml. Detects a band of approximately 140 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Konzentration	0.5 mg/ml
Reinheit	Immunogen affinity purified
Buffer	Preservative: 0.05% Sodium AzideConstituents: PBS (without Mg2+ and Ca2+), 1.0mg/ml BSA (IgG, protease free). pH 7.3
Lagerung	Aliquot and store at -20C or -80C. Avoid repeated freeze / thaw cycles
Beschränkungen	For research use only

Google Scholar	Suchen Sie in Google Scholar™ nach weiteren Artikeln für Antigen c-Abl (phospho Y412)
EMBL Harvester	Genom von Mensch, Maus oder Ratte nach Antigen c-Abl (phospho Y412) durchsuchen (Bioinformatic Harvester (EMBL))