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Détail du produit pour c-Abl (phospho Y412) (Human) antibody
c-Abl (phospho Y412) (Human) antibody
Aperçu
| Antigène: | C-Abl (phospho Y412) |
| Type anticorps: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivité: | Human, Mouse (Murine) |
| Hôte: | Rabbit |
| Quantité: | |
| Prix: | 271,00 € (Plus frais de livraison et TVA) |
| Numéro de commande: | ABIN146629 |
| Disponibilité: | 7 to 10 days until shipment |
Description du produit: c-Abl (phospho Y412) (Human) antibody
| Antigène | C-Abl (phospho Y412) |
| Immunogène | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more c |
| Reactivité | Human, Mouse (Murine) |
| Type anticorps | Polyclonal |
| Format | Liquid |
| Isotype | IgG »Anticorps secondaires correspondants |
| Description | C-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245. |
| Hôte | Rabbit |
Applications: c-Abl (phospho Y412) (Human) antibody
| Application | Western Blotting (WB) |
| Indications d'application | WB: Use at a concentration of 0.1-1.0 ug/ml. Detects a band of approximately 140 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.5 mg/ml |
| Pureté | Immunogen affinity purified |
| Buffer | Preservative: 0.05% Sodium AzideConstituents: PBS (without Mg2+ and Ca2+), 1.0mg/ml BSA (IgG, protease free). pH 7.3 |
| Stock | Aliquot and store at -20C or -80C. Avoid repeated freeze / thaw cycles |
| Restrictions | For research use only |
Informations supplémentaires: c-Abl (phospho Y412) (Human) antibody
| Google Scholar | Trouver des références supplémentaires pour antigène c-Abl (phospho Y412) sur Google Scholar™ |
| EMBL Harvester | Recherche humain, souris ou rat génome pour antigène c-Abl (phospho Y412) (Bioinformatic Harvester (EMBL)) |
