BASKET
HELP
Product details for c-ErbB2 (Human) antibody
c-ErbB2 (Human) antibody
Overview
| Antigen: | C-ErbB2 |
| Antibody Type: | Monoclonal |
| Application: | Immunohistochemistry (Formalin-fixed Sections) (IHC(f)), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP) |
| Reactivity: | Human, Dog (Canine) |
| Host: | Mouse |
| Quantity: | |
| Price: | 393,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN139922 |
| Availability: | 7 to 10 days until shipment |
Additional Information: c-ErbB2 (Human) antibody
| Antigen | C-ErbB2 |
| Immunogen | Cells overexpressing the human c-ErbB2/c-Neu antigen |
| Reactivity | Human, Dog (Canine) |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | Neu (from neuroglioblastomas) is also referred to as erbB-2 (from erythroblastosis virus) and HER2 (for Human Epidermal growth factor Receptor) and is the second member of the EGF receptor family to be described.The human proto-oncogene c-ErbB2/c-neu is upregulated in approximately 30%of breast carcinomas, this amplification maybe useful as a predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways. Indeed overexpression of human c-ErbB2/c-neu induces cellular transformation. In rat models, a point mutation has been located within the transmembrane domain of the c-ErbB2/c-neu oncogene. |
| Clone | 9G6 |
| Host | Mouse |
| Specificity | ABIN139922 reacts with a cell surface epitope of c-Erb2/c-neu but does not cross-react with the EGF receptor. Ductal carcinomas in situ displaying large-cell, comedo growth type, were stained while none of 16 ductal carcinomas in situ of small-cell, papilla |
Application Details: c-ErbB2 (Human) antibody
| Application | Immunohistochemistry (Formalin-fixed Sections) (IHC(f)), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP) |
| Application Notes | IHC-Fr: Use at a concentration of 5 ug/ml. IHC-P: Use at an assay dependent dilution. IP: Use at a concentration of 1 ug/ml(immunoprecipitates 185,000 dalton c-ErbB2/c-neu protein),Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 1 mg/ml |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: 0.1% Sodium Azide. Constituents: 0.2% Gelatin, 50mM Sodium phosphate buffer |
| Storage | Store at 4C. Aliquot and store at -20C long-term. |
| Restrictions | For research use only |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
