|
Antigène
|
C-Ets 1
|
|
Immunogène
|
Synthetic peptide: YENDYPSVILRDPL, corresponding to amino acids 201-214 of Human c-Ets 1.
|
|
Reactivité
|
Human, Mouse (Murine), Rat, Rabbit
|
|
Type anticorps
|
Polyclonal
|
|
Isotype
|
IgG »Anticorps secondaires correspondants
|
|
Description
|
The oncogene v-ets was originally discovered as a component of a chimeric genome, along with a truncated v-myb gene, present in the genome of E26, an avian leukosis virus. Members of the ETS gene family have been cloned and sequenced from a variety of species ranging from human to Drosophila, their encoded products are highly conserved, more so than other known nuclear protooncogene products. The several classes of ETS family members could be due to an ancestral gene duplication, followed by genetic recombination(s) or divergence, however, since all of the classes are present in both invertebrates and vertebrates, such an ancestral duplication must predate the emergence of chordates more than 500 million years ago (review by Seth et al., 1992). ETS1 encodes a set of nuclear phosphoproteins ranging in size from 42 to 52 kD. The ETS proteins are transcription factors which activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the T
|
|
Hôte
|
Rabbit
|
PANIER
AIDE
Antigènes
