BASKET
HELP
Product details for c-Fos (Human) antibody
c-Fos (Human) antibody
Overview
|
|
| Antigen: | C-Fos |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 330,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN149753 |
| Availability: | 7 to 10 days until shipment |
Additional Information: c-Fos (Human) antibody
| Antigen | C-Fos |
| Immunogen | Synthetic peptide (Human) (N terminal). |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Polyclonal |
| Isotype | IgG »Matching secondary antibodies |
| Description | The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4). |
| Host | Rabbit |
| Specificity | Reacts with c-Fos |
Application Details: c-Fos (Human) antibody
| Application | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | IHC-Fr: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. WB: Use at an assay dependent concentration. Can be blocked with GTX28015 p21 (C-term) peptide (human) . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.2 mg/ml |
| Purity | IgG fraction |
| Buffer | PBS with 0.1% sodium azide |
| Storage | Store this product at 4 C, do not freeze. The product is stable for one year from the date of shipment. |
| Restrictions | For research use only |
External Information: c-Fos (Human) antibody
| Google Scholar | Find more references for antigen c-Fos on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen c-Fos (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
