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Product details for c-Ret (R787) (Human) antibody
c-Ret (R787) (Human) antibody
Overview
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| Antigen: | C-Ret (R787) |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry (IHC), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN180119 |
| Availability: | 10 days until shipment |
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Additional Information: c-Ret (R787) (Human) antibody
| Antigen | C-Ret (R787) |
| Immunogen | Synthetic peptide for C-Terminal of Human c-Ret (STWIENKLYGRISHAFTRF) Purification: Affinity Purified with synthetic peptide |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Isotype | IgG »Matching secondary antibodies |
| Description | The ret proto-oncogene products (proto-Ret protein) are expressed as 150kDa and 170kDa glycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma, pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the proto-Ret protein contains a cadherin-related sequence that is known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the proto-Ret protein consists of about 110 amino acids and is tandemly repeated 3 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the proto-Ret protein showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the proto-Ret protein may function as a cell adhesion molecule like cadherins. |
| Host | Rabbit |
| Specificity | Crossreactivities with mouse and rat |
Application Details: c-Ret (R787) (Human) antibody
| Application | Immunohistochemistry (IHC), Western Blotting (WB) |
| Application Notes | This antibody can be used for immunohistochemical staining on frozen sections in concentration of 2-5 ug/ml. This antibody can be used for western blotting in concentration of about 5 ug/ml. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Restrictions | For Research Use only |
External Information: c-Ret (R787) (Human) antibody
| Google Scholar | Find more references for antigen c-Ret (R787) on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen c-Ret (R787) (Bioinformatic Harvester (EMBL)) |
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