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Product details for C-erbB-2 (Human) antibody
C-erbB-2 (Human) antibody
Overview
| Antigen: | C-erbB-2 / Her-2 / neu |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 420,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN151263 |
| Availability: | Ships in 7 to 10 days |
Additional Information: C-erbB-2 (Human) antibody
| Antigen | C-erbB-2 / Her-2 / neu |
| Gene ID | 2064 |
| Immunogen | The epitope recognized maps to a region between residues 1200 and the C-terminus(residue 1255) of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2using the numbering given in entry NP_004439.2 (GeneID 2064). |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Aff - Purified |
| Description | ErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosinekinase from the EGFR family that acts to regulate a variety of biological responsesincluding cell growth, differentiation, and tissue development. Ligand binding to theextracellular domain, or overexpression of the receptor leads to phosphorylation onseveral tyrosine residues within the cytoplasmic domain, and activation. Overexpressionor abnormal activation of ErbB2 has been found in a variety of tumors including brain,breast, lung and skin cancer. Tyrosine 1248 within the cytoplasmic domain of thereceptor is an auto-phosphorylation site that allows binding of Shc and activation of theRas, Raf, ERK1&2 signaling pathway. Synonyms: ErbB2 antibody, ErbB-2 antibody, c-erb B2 antibody, v-erb-b2 erythroblastic leukemiaviral oncogene homolog 2 antibody, HER2 antibody, HER-2 antibody, Neu antibody,NGL antibody, Neuroblastoma- or Glioblastoma-Derived antibody, TKR1 antibody,Tyrosine Kinase-type Cell Surface Receptor Her2 antibody |
| Host | Rabbit |
| Specificity | This antibody cross-reacts with human. Other species have not been tested. |
Application Details: C-erbB-2 (Human) antibody
| Application | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Application Notes | Suggested working dilutions *immunohistochemistry * Investigator should determine optimal working dilutions. This antibody is useful for immunohistochemistry. No other applications have beentested. Suggested working dilution: *Immunohistochemistry: 1:100-1:500 (FFPE sections)Epitope exposure is not recommended (citrate buffer may hinder staining). Likely towork with frozen sections.*The investigator should determine the optimal working dilution for a specific application. * Other applications have not been tested. |
| Buffer | Tris-buffered Saline containing 0.1% BSA with 0.09% Sodium Azide 0.1 ml of affinity purified antisera in Tris-buffered Saline containing 0.1% BSA with0.09% sodium azide. The antibody was affinity purified using an epitope specific for theprotein, immobili |
| Storage | Store at 2-8 degrees Celcius. |
| Research Area | Receptors, Growth Factors |
| Restrictions | For Research Use only |
External Information: C-erbB-2 (Human) antibody
| Google Scholar | Find more references for antigen C-erbB-2 / Her-2 / neu on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen C-erbB-2 / Her-2 / neu (Bioinformatic Harvester (EMBL)) |
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