The following gene names and symbols are associated with antigen ADAM Metallopeptidase Domain 17 across different species:

ADAM metallopeptidase domain 17 (ADAM17), a disintegrin and metallopeptidase domain 17 (Adam17), ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) (ADAM17), a disintegrin and metallopeptidase domain 17b (adam17b), disintegrin metalloproteinase (adam17)

Other aliases include:

CSVP, TACE, ADAM18, CD156B, MGC71942, Tace, CD156b, ADAM17, adam17, si:dkey-81b15.2

On the protein level the following designations are being used for antigen ADAM Metallopeptidase Domain 17:

a disintegrin and metalloprotease domain 17 – snake venom-like protease – TNF-alpha converting enzyme – ADAM metallopeptidase domain 18 – tumor necrosis factor, alpha, converting enzyme – OTTMUSP00000023111 – a disintegrin and metalloproteinase domain 17 – a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme – ADAM 17 – a disintegrin and metallopeptidase domain 17 – tumor necrosis factor alpha converting enzyme – a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) – ADAM metallopeptidase domain 17 – ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) – a disintegrin and metallopeptidase domain 17b – disintegrin and metalloproteinase domain-containing protein 17-like

ADAM Metallopeptidase Domain 17 fulfills a number of functions:

PDZ domain binding – SH3 domain binding – integrin binding – interleukin-6 receptor binding – metal ion binding – metalloendopeptidase activity – peptidase activity – protein binding – zinc ion binding – hydrolase activity – metallopeptidase activity

ADAM Metallopeptidase Domain 17 is relevant to the following processes:

B cell differentiation – Notch signaling pathway – PMA-inducible membrane protein ectodomain proteolysis – T cell differentiation in the thymus – cell adhesion mediated by integrin – cell motility – epidermal growth factor receptor signaling pathway – germinal center formation – membrane protein intracellular domain proteolysis – negative regulation of interleukin-8 production – neutrophil mediated immunity – positive regulation of T cell chemotaxis – positive regulation of cell growth – positive regulation of cell migration – positive regulation of cell proliferation – positive regulation of chemokine production – positive regulation of cyclin-dependent protein kinase activity during G1/S – positive regulation of epidermal growth factor receptor activity – positive regulation of protein amino acid phosphorylation – positive regulation of transforming growth factor beta receptor signaling pathway – proteolysis – regulation of mast cell apoptosis – response to bacterium – response to drug – response to high density lipoprotein stimulus – response to hypoxia – response to lipopolysaccharide – spleen development – wound healing, spreading of epidermal cells – integrin-mediated signaling pathway – positive regulation of cell motion

Locations for ADAM Metallopeptidase Domain 17:

actin cytoskeleton – apical plasma membrane – cell surface – cell-cell junction – cytoplasm – focal adhesion – integral to plasma membrane – membrane – membrane raft – ruffle membrane – extracellular region – integral to membrane – plasma membrane – proteinaceous extracellular matrix

Source: NCBI Entrez Gene, Gene Ontology