The following gene names and symbols are associated with antigen CD28 across different species:

CD28 molecule (CD28)

Other aliases include:

Tp44, MGC138290

On the protein level the following designations are being used for antigen CD28:

CD28 antigen – CD28 antigen (Tp44) – T-cell-specific surface glycoprotein

CD28 fulfills a number of functions:

coreceptor activity – identical protein binding

CD28 is relevant to the following processes:

cell surface receptor linked signal transduction – cytokine biosynthetic process – humoral immune response – positive regulation of T cell proliferation – positive regulation of anti-apoptosis – positive regulation of interleukin-2 biosynthetic process – positive regulation of mitosis – positive regulation of translation – positive regulation of viral genome replication – regulation of defense response to virus by virus – regulatory T cell differentiation

Locations for CD28:

cytosol – external side of plasma membrane – integral to plasma membrane – plasma membrane

Source: NCBI Entrez Gene, Gene Ontology