The following gene names and symbols are associated with antigen Leucine-Rich Repeat Kinase 2 across different species:

leucine-rich repeat kinase 2 (Lrrk2), leucine-rich repeat kinase 2 (LRRK2), leucine-rich repeat kinase 2 (lrrk2)

Other aliases include:

Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, PARK8, RIPK7, ROCO2, AURA17, DARDARIN, LRRK2

On the protein level the following designations are being used for antigen Leucine-Rich Repeat Kinase 2:

leucine-rich repeat kinase 2 – OTTMUSP00000022827 – augmented in rheumatoid arthritis 17 – leucine-rich repeat serine/threonine-protein kinase 2 – leucine-rich repeat kinase 2-like – leucine-rich repeat serine/threonine-protein kinase 2-like

Leucine-Rich Repeat Kinase 2 fulfills a number of functions:

ATP binding – GTP binding – GTP-dependent protein kinase activity – GTPase activator activity – binding – kinase activity – nucleotide binding – protein binding – protein kinase activity – protein serine/threonine kinase activity – transferase activity – protein homodimerization activity – GTPase activity – MAP kinase kinase activity

Leucine-Rich Repeat Kinase 2 is relevant to the following processes:

protein amino acid autophosphorylation – protein amino acid phosphorylation – small GTPase mediated signal transduction – MAPKKK cascade – positive regulation of programmed cell death – positive regulation of protein ubiquitination – activation of MAPKK activity – determination of adult lifespan – neuron death – peptidyl-serine phosphorylation – regulation of locomotion – response to oxidative stress

Locations for Leucine-Rich Repeat Kinase 2:

intracellular – membrane raft – plasma membrane – synaptic vesicle – trans-Golgi network – cytoplasm – external side of mitochondrial outer membrane – extrinsic to membrane – membrane fraction – axon – dendrite – microsome – synaptosome

Source: NCBI Entrez Gene, Gene Ontology