The following gene names and symbols are associated with antigen Rap Guanine Nucleotide Exchange Factor (GEF) 4 across different species:

Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), Rap guanine nucleotide exchange factor (GEF) 4 (Rapgef4), Rap guanine nucleotide exchange factor (GEF) 4 (LOC100348394), rap guanine nucleotide exchange factor 4 (PTRG_05798)

Other aliases include:

CGEF2, EPAC2, Nbla00496, CAMP-GEFII, CAMPS, Cgef2, Epac2, RAPGEF4, KIAA4040, mKIAA4040, 1300003D15Rik, 5730402K07Rik, 6330581N18Rik, DKFZp459F152, DKFZp459K033

On the protein level the following designations are being used for antigen Rap Guanine Nucleotide Exchange Factor (GEF) 4:

Rap guanine nucleotide exchange factor (GEF) 4 – putative protein product of Nbla00496 – exchange protein directly activated by cAMP 2 – RAP guanine-nucleotide-exchange factor (GEF) 4 – cAMP-regulated guanine nucleotide exchange factor II – rap guanine nucleotide exchange factor 4 – epac 2 – exchange factor directly activated by cAMP 2 – cAMP-GEFII – OTTMUSP00000014141 – OTTMUSP00000014142 – cAMP-regulated guanine nucleotide exchange factor IIB – cAMP-dependent Rap1 guanine-nucleotide exchange factor – rap guanine nucleotide exchange factor 4-like

Rap Guanine Nucleotide Exchange Factor (GEF) 4 fulfills a number of functions:

cAMP binding – cAMP-dependent protein kinase regulator activity – guanyl-nucleotide exchange factor activity – nucleotide binding – Ras GTPase binding – Ras guanyl-nucleotide exchange factor activity – protein binding – protein complex binding

Rap Guanine Nucleotide Exchange Factor (GEF) 4 is relevant to the following processes:

G-protein coupled receptor protein signaling pathway – exocytosis – regulation of protein amino acid phosphorylation – regulation of small GTPase mediated signal transduction – cAMP-mediated signaling – calcium ion-dependent exocytosis – heart development – insulin secretion – intracellular signaling pathway – negative regulation of synaptic transmission – positive regulation of smooth muscle cell migration – regulation of catalytic activity – regulation of dendrite development – regulation of exocytosis – signal transduction – small GTPase mediated signal transduction

Locations for Rap Guanine Nucleotide Exchange Factor (GEF) 4:

cAMP-dependent protein kinase complex – cytoplasm – extrinsic to membrane – intracellular – membrane – membrane fraction – apical plasma membrane – axon – basolateral plasma membrane – cytosol – dendrite – dendritic spine – excitatory synapse – photoreceptor inner segment – photoreceptor outer segment – plasma membrane – protein complex

Source: NCBI Entrez Gene, Gene Ontology