The following gene names and symbols are associated with antigen SH2B Adaptor Protein 2 across different species:

SH2B adaptor protein 2 (SH2B2), SH2B adaptor protein 2 (Sh2b2), PRKR interacting protein 1 (IL11 inducible) (PRKRIP1)

Other aliases include:

APS, Aps, SH2B2

On the protein level the following designations are being used for antigen SH2B Adaptor Protein 2:

SH2B adaptor protein 2 – SH2 and PH domain-containing adapter protein APS – adaptor protein with pleckstrin homology and src homology 2 domains – insulin receptor substrate 5 – PRKR interacting protein 1 (IL11 inducible) – alpha-1-antiproteinase S – alpha-1-antitrypsin – alpha-1-proteinase inhibitor – SH2B adapter protein 2-like

SH2B Adaptor Protein 2 fulfills a number of functions:

JAK pathway signal transduction adaptor activity – SH3/SH2 adaptor activity – protein binding – signal transducer activity – transmembrane receptor protein tyrosine kinase adaptor protein activity – double-stranded RNA binding – protein kinase binding – protein kinase inhibitor activity

SH2B Adaptor Protein 2 is relevant to the following processes:

insulin receptor signaling pathway – intracellular signaling cascade – B-1 B cell homeostasis – actin cytoskeleton organization – antigen receptor-mediated signaling pathway – brown fat cell differentiation – cytokine-mediated signaling pathway – glucose homeostasis – negative regulation of glucose import – regulation of immune response – regulation of metabolic process – nervous system development – regulation of Ras protein signal transduction – negative regulation of phosphorylation – negative regulation of protein kinase activity – intracellular signaling pathway

Locations for SH2B Adaptor Protein 2:

cytoplasm – plasma membrane – actin filament – membrane – ruffle – stress fiber – nucleolus – nucleus

Source: NCBI Entrez Gene, Gene Ontology