The following gene names and symbols are associated with antigen Topoisomerase (DNA) II alpha 170kDa across different species:

topoisomerase (DNA) II alpha 170kDa (TOP2A), DNA topoisomerase II, alpha isozyme (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705)

Other aliases include:

TOP2, TP2A, TOP2A

On the protein level the following designations are being used for antigen Topoisomerase (DNA) II alpha 170kDa:

DNA topoisomerase II, alpha isozyme – OTTHUMP00000207108 – DNA topoisomerase II, 170 kD

Topoisomerase (DNA) II alpha 170kDa fulfills a number of functions:

ATP binding – DNA topoisomerase (ATP-hydrolyzing) activity – DNA-dependent ATPase activity – chromatin binding – drug binding – histone deacetylase binding – nucleotide binding – protein C-terminus binding – protein heterodimerization activity – protein homodimerization activity – protein kinase C binding – ubiquitin binding

Topoisomerase (DNA) II alpha 170kDa is relevant to the following processes:

DNA ligation – DNA repair – DNA replication – DNA topological change – apoptotic chromosome condensation – chromosome segregation – phosphoinositide-mediated signaling – positive regulation of apoptosis – positive regulation of retroviral genome replication – response to DNA damage stimulus

Locations for Topoisomerase (DNA) II alpha 170kDa:

DNA topoisomerase complex (ATP-hydrolyzing) – centriole – chromosome – cytoplasm – nucleolus – nucleoplasm – nucleus – viral integration complex

Source: NCBI Entrez Gene, Gene Ontology