The following gene names and symbols are associated with antigen Tuberous Sclerosis 1 across different species:

tuberous sclerosis 1 (TSC1), tuberous sclerosis 1 (Tsc1), tuberous sclerosis 1 (tsc1)

Other aliases include:

LAM, TSC, KIAA0243, MGC86987, hamartin, mKIAA0243, TSC1, MGC165718

On the protein level the following designations are being used for antigen Tuberous Sclerosis 1:

tuberous sclerosis 1 protein – hamartin – tumor suppressor – OTTHUMP00000022439 – OTTHUMP00000198378 – tuberous sclerosis 1 protein homolog – OTTMUSP00000012518 – OTTMUSP00000012519 – OTTMUSP00000012522 – OTTMUSP00000012523 – tuberous sclerosis 1 – chromosome 9 TSC1 – hamartin-like

Tuberous Sclerosis 1 fulfills a number of functions:

chaperone binding – protein N-terminus binding – GTPase activating protein binding – GTPase regulator activity – protein binding

Tuberous Sclerosis 1 is relevant to the following processes:

activation of Rho GTPase activity – negative regulation of TOR signaling pathway – negative regulation of cell proliferation – negative regulation of protein ubiquitination – negative regulation of translation – positive regulation of focal adhesion formation – rRNA export from nucleus – regulation of cell-matrix adhesion – regulation of phosphoprotein phosphatase activity – regulation of stress fiber formation – response to insulin stimulus – cardiac muscle cell differentiation – cell projection organization – cell-matrix adhesion – cerebral cortex development – embryo development – hippocampus development – kidney development – myelination – negative regulation of TOR signaling cascade – negative regulation of cell size – nervous system development – neural tube closure – positive regulation of focal adhesion assembly – potassium ion transport – protein heterooligomerization – regulation of actin cytoskeleton organization – regulation of focal adhesion assembly – regulation of protein kinase activity – regulation of stress fiber assembly – regulation of translation – synapse organization

Locations for Tuberous Sclerosis 1:

TSC1-TSC2 complex – actin filament – cell cortex – cytoplasm – cytosol – extrinsic to membrane – lamellipodium – membrane – membrane fraction – cytoskeletal part – growth cone – microsome – protein complex

Source: NCBI Entrez Gene, Gene Ontology