The following gene names and symbols are associated with antigen beta-Site APP-Cleaving Enzyme 1 across different species:

beta-site APP-cleaving enzyme 1 (BACE1), beta-site APP cleaving enzyme 1 (Bace1), zgc:77409 (zgc:77409), beta-site APP-cleaving enzyme 1 (MGC145931), beta-site APP-cleaving enzyme 1 (LOC100232107), beta-site APP-cleaving enzyme 1 (LOC100343442), beta-site APP-cleaving enzyme 2 (BACE2), beta-site APP-cleaving enzyme 2 (Bace2), beta-site APP-cleaving enzyme 2 (bace2), beta-site APP-cleaving enzyme 2 (LOC100224177)

Other aliases include:

ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2

On the protein level the following designations are being used for antigen beta-Site APP-Cleaving Enzyme 1:

beta-site APP-cleaving enzyme 1 – memapsin-2 – beta-secretase – APP beta-secretase – aspartyl protease 2 – transmembrane aspartic proteinase Asp2 – membrane-associated aspartic protease 2 – beta-site amyloid precursor protein cleaving enzyme – beta-site amyloid beta A4 precursor protein-cleaving enzyme – beta-site APP cleaving enzyme 1 – beta-site APP cleaving enzyme – beta secretase 1 – beta-site amyloid precursor protein cleaving enzyme 1 – beta-secretase 1-like – beta-site APP-cleaving enzyme 2 – memapsin-1 – beta secretase 2 – aspartyl protease 1 – 56 kDa aspartic-like protease – Down syndrome region aspartic protease – transmembrane aspartic proteinase Asp1 – membrane-associated aspartic protease 1 – beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 – beta-site APP cleaving enzyme 2 – beta-secretase 2-like

beta-Site APP-Cleaving Enzyme 1 fulfills a number of functions:

aspartic-type endopeptidase activity – beta-aspartyl-peptidase activity – peptidase activity – endopeptidase activity – hydrolase activity

beta-Site APP-Cleaving Enzyme 1 is relevant to the following processes:

beta-amyloid metabolic process – membrane protein ectodomain proteolysis – proteolysis – negative regulation of amyloid precursor protein biosynthetic process – peptide hormone processing – protein modification process – protein secretion

Locations for beta-Site APP-Cleaving Enzyme 1:

Golgi apparatus – endosome – integral to plasma membrane – membrane – trans-Golgi network – axon – cytoplasmic vesicle – endoplasmic reticulum – integral to membrane – membrane fraction – cellular_component

Source: NCBI Entrez Gene, Gene Ontology