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anti-Human ABL1 Antibodies:
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Human Monoclonal ABL1 Primary Antibody for IF, IP - ABIN967410
Guo, Lian, Xian, Lee, Deisseroth, Stass, Champlin, Talpaz, Wang, Arlinghaus: BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy. in Blood 1994
Show all 7 Pubmed References
Human Polyclonal ABL1 Primary Antibody for IHC - ABIN965709
Kawai, Nie, Yuan: Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. in Molecular and cellular biology 2002
Show all 4 Pubmed References
Polyclonal ABL1 Primary Antibody for IF, IHC (p) - ABIN4948294
Danial, Rothman: JAK-STAT signaling activated by Abl oncogenes. in Oncogene 2000
Show all 3 Pubmed References
Human ABL1 Primary Antibody for IHC - ABIN965708
Sionov, Coen, Goldberg, Berger, Bercovich, Ben-Neriah, Ciechanover, Haupt: c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. in Molecular and cellular biology 2001
Show all 4 Pubmed References
Human Polyclonal ABL1 Primary Antibody for WB - ABIN4285621
Yang, Roselli, Patchev, Yu, Almeida: Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons. in The Journal of biological chemistry 2013
Human Polyclonal ABL1 Primary Antibody for IHC, ELISA - ABIN1584122
Chen, Ren, Liang, Zha, Liu, Chen, Singhal, Ding: c-Abl mediates angiotensin II-induced apoptosis in podocytes. in Journal of molecular histology 2013
Human Polyclonal ABL1 Primary Antibody for ICC, IF - ABIN4285624
Sun, Chen, Zhang, Xie, Hou, Hui, Xu, Du, Zhou, Su, Gao: Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. in Scientific reports 2014
Human Polyclonal ABL1 Primary Antibody for DB, IHC (p) - ABIN389501
Barnes, McIntosh, Whetton, Daley, Bentley, Baldwin: Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. in Oncogene 2005
Show all 6 Pubmed References
Human Monoclonal ABL1 Primary Antibody for ELISA, WB - ABIN965498
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Show all 2 Pubmed References
Human Monoclonal ABL1 Primary Antibody for ELISA, WB - ABIN968942
Lu, Finnis, Xiang, Lee, Markowitz, Okhrimenko, Brodie: Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells. in Biochemical and biophysical research communications 2006
Show all 2 Pubmed References
c-Abl has a critical role in alpha-synuclein-induced neurodegeneration; selective inhibition of c-Abl may be neuroprotective
We demonstrate that nanopore technology is suitable for employment in the hematology laboratory for detecting BCR (show BCR Antibodies)-ABL1 kinase domain mutation in Philadelphia-positive leukemias.
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (show APOB Antibodies) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP (show MTTP Antibodies) is required for secretion of intact APOB (show APOB Antibodies) but not of truncated APOB (show APOB Antibodies). (APOB (show APOB Antibodies) = apolipoprotein B (show APOB Antibodies); MTTP (show MTTP Antibodies) = microsomal triglyceride transfer protein (show MTTP Antibodies))
Frequent molecular monitoring and intervention are required for patients who do not show a reduction in BCR (show BCR Antibodies)-ABL1 transcripts to these levels after stem cell transplantation.
c-Abl promotes TGF-beta (show TGFB1 Antibodies)-induced SKIP/Smad3 (show SMAD3 Antibodies) interaction.
Data indicate the feasibility of detecting ABL1 mutations in cerebrospinal fluid (CSF (show CSF2 Antibodies)) by next-generation sequencing (NGS) in patients with central nervous system relapse in BCR (show BCR Antibodies)-ABL1-positive acute lymphoblastic leukemia.
the e13a2 BCR (show BCR Antibodies)-ABL1 fusion transcript affects the rate, the depth, and the speed of the response to treatment with imatinib firstline, and that including the transcript type in the calculation of the baseline risk scores may improve prognostic stratification and may help the choice of the best treatment policy.
Normal ABL1 is a tumor suppressor in BCR (show BCR Antibodies)-ABL1-induced leukemia. Allosteric stimulation of the normal ABL1 kinase (show BCR Antibodies) activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors.
the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (show BCL11A Antibodies) cells and can be regulated by BCR/ABL signal transduction through downstream phosphoinositide 3-kinase/Akt (show AKT1 Antibodies) and Janus kinase/signal transducer and activator of transcription (show STAT1 Antibodies) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (show BCL11A Antibodies).
this study shows that signaling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse
ABL potentiated the assembly and activation of the RUNX2 (show RUNX2 Antibodies)-TAZ (show TAZ Antibodies) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Antibodies)-mediated adipogenesis.
Normal ABL1 is a tumor suppressor in BCR (show BCR Antibodies)-ABL1-induced leukemia. ABL1 inhibits expansion and proliferation of BCR (show BCR Antibodies)-ABL1-expressing leukemic stem cells. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase (show TYRO3 Antibodies) inhibitors.
p38a (show MAPK14 Antibodies) as a major substrate of c-Abl both in vitro and in vivo and c-Abl-mediated phosphorylation is critical for the dimerization of p38a (show MAPK14 Antibodies).
Our data show that: i) HDAC2 (show HDAC2 Antibodies) levels and activity are increased in NPC (show NPC1 Antibodies) neuronal models and in Npc1 (show NPC1 Antibodies)(-/-) mice; ii) inhibition of c-Abl or c-Abl deficiency prevents the increase of HDAC2 (show HDAC2 Antibodies) protein levels and activity in NPC (show NPC1 Antibodies) neuronal models
The resistance in BCR (show BCR Antibodies)-ABL1 cells resulted either from the Y253H mutation in the BCR (show BCR Antibodies)-ABL1 gene or incubation in increasing concentrations of imatinib.
These results reveal a new pathway in the DNA damage response wherein ABL-dependent tyrosine phosphorylation of DGCR8 (show DGCR8 Antibodies) stimulates the processing of selective primary miRNAs.
These findings connect the EphB signaling pathway to the regulation of intestinal adenoma initiation via Abl kinase.
overexpression of Id2 in primary alveolar epithelial cells promotes proliferation by inhibiting a retinoblastoma protein/c-Abl interaction leading to greater c-Abl activity.
MIG-13 (show DHPS Antibodies)-WAVE pathway provides the major force for directional cell motility, whereas MIG-13 (show DHPS Antibodies)-WASP (show WASL Antibodies) partially compensates for its loss, underscoring their coordinated activities in facilitating robust cell migration.
By screening candidate genes involved in Eph (show EPHA1 Antibodies) signaling, we find that the Eph (show EPHA1 Antibodies) kinase-independent pathway involves the ABL-1 nonreceptor tyrosine kinase (show TYRO3 Antibodies) and possibly the phosphatidylinositol 3-kinase pathway
The trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys (show LYZ Antibodies)-7 and the tyrosine kinase abl-1.
oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 (show TP53 Antibodies) and EGL-1 independent pathway; the MAPK (show MAPK1 Antibodies) kinases MEK-1 (show MAP2K1 Antibodies) and SEK-1 (show MAP2K4 Antibodies), and the p53 (show TP53 Antibodies) antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis
findings demonstrate that ABL-1, the C. elegans homolog of the mammalian c-Abl nonreceptor tyrosine kinase (show TYRO3 Antibodies) ABL1, is required for Shigella flexneri pathogenesis in nematodes
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
c-abl oncogene 1, receptor tyrosine kinase
, v-abl Abelson murine leukemia viral oncogene homolog 1
, Abelson murine leukemia viral (v-abl) oncogene homolog 1
, v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
, tyrosine kinase ABL
, Abelson murine leukemia viral (v-abl) oncogene homolog 2
, Abelson tyrosine-protein kinase 2
, arg, Abelson-related
, tyrosine-protein kinase ABL2
, v-abl Abelson murine leukemia viral oncogene homolog 2
, arg tyrosine kinase
, tyrosine-protein kinase ABL2-like
, Abelson tyrosine-protein kinase 1
, bcr/c-abl oncogene protein
, proto-oncogene c-Abl
, proto-oncogene tyrosine-protein kinase ABL1
, tyrosine-protein kinase ABL1
, Abelson murine leukemia oncogene
, abelson murine leukemia viral oncogene homolog 1
, v-abl Abelson murine leukemia oncogene 1
, v-abl Abelson murine leukemia viral oncogene 1
, microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein large subunit