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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||5 Antibodies|
|Flow Cytometry (FACS)||10 Antibodies|
|Immunocytochemistry (ICC)||15 Antibodies|
|Immunofluorescence (IF)||37 Antibodies|
|Immunohistochemistry (IHC)||22 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||23 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Luminex Assay (LMNX)||2 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|RNA Interference (RNAi)||1 Antibodies|
|Western Blotting (WB)||65 Antibodies|
|Antigen||Baculoviral IAP Repeat-Containing 5 (BIRC5) Antibodies|
|Conjugate||This BIRC5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-BIRC5 AntibodyTarget Details BIRC5 Application Details Handling References for anti-BIRC5 Antibody (ABIN401046) Images
|Specificity||This antibody is directed against Survivin protein.|
|Immunogen||Synthetic peptide corresponding to a region near the carboxy terminus of human Survivin protein|
Target Details BIRC5Product Details anti-BIRC5 Antibody Application Details Handling References for anti-BIRC5 Antibody (ABIN401046) Images back to top
|Alternative Name||IAP4 / BIRC5 (BIRC5 Antibody Abstract)|
|Background||Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli, including members of the TNF family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated Survivin (also referred to as apoptosis inhibitor 4 (API4) and TIAP). Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin|
|Research Area||Cancer, Apoptosis/Necrosis, Neurology|
|Pathways||Apoptosis, Cell Division Cycle|
Application DetailsProduct Details anti-BIRC5 Antibody Target Details BIRC5 Handling References for anti-BIRC5 Antibody (ABIN401046) Images back to top
ELISA: 1/10000 - 1/40000. Western Blot: 1/200 - 1/2000. Immunofluorescence: 1/100 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BIRC5 Antibody Target Details BIRC5 Application Details References for anti-BIRC5 Antibody (ABIN401046) Images back to top
|Concentration||1.0 mg/mL (by UV absorbance at 280 nm)|
|Buffer||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
References for anti-BIRC5 Antibody (ABIN401046)Product Details anti-BIRC5 Antibody Target Details BIRC5 Application Details Handling Images back to top
Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).
ImagesProduct Details anti-BIRC5 Antibody Target Details BIRC5 Application Details Handling References for anti-BIRC5 Antibody (ABIN401046) back to top