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Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (show CRTC2 Proteins)/Akt (show AKT1 Proteins) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 (show CAPN1 Proteins) and calpain-2 (show CAPN2 Proteins) are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Proteins) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (show CAPN2 Proteins) is widely activated in pyramidal neurons of CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (show GRIN1 Proteins) transporters GLT1 (show SLC1A2 Proteins) and GLAST (show SLC1A3 Proteins) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Attenuation of atherosclerotic lesions/inflammation in ApoE (show APOE Proteins) KO mice by simvastatin might be associated with the downregulation of CD36 (show CD36 Proteins) and calpain-1 (show CAPN1 Proteins).
Leukocyte calpain-1 (show CAPN1 Proteins)/calpain-2 (show CAPN2 Proteins) deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
the cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported.
Calpain-1 (show CAPN1 Proteins) expression is associated with poor relapse-free survival in breast cancer patients treated with trastuzumab.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
HRNR (show HRNR Proteins) deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (show CAPN1 Proteins).
calpain and protein kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins) abnormal release promotes a constitutive release of matrix metalloproteinase 9 (show MMP9 Proteins) in peripheral blood mononuclear cells from cystic fibrosis (show S100A8 Proteins) patients
our findings suggest that the gene/protein expression of both CAPN1 and CAPN2 (show CAPN2 Proteins), as well as the ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.
This study demonstrated that Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.
the calpain-dependent cleavage of Nav1.6 (show SCN8A Proteins) channels expressed in human embryonic kidney (HEK (show EPHA3 Proteins)) 293 cells caused the upregulation of I(NaP (show CTNNBL1 Proteins))
study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression
This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.
Suppression of CANP1 resulted in the activation of caspase (show CASP3 Proteins) and heat-shock-protein systems which might in turn regulate apoptosis through the caspase (show CASP3 Proteins)-dependent cell death pathway. [CANP1]
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures
This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Proteins) as a selection marker for beef quality.
It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
Association of polymorphisms in calpain 1 (show CAPN1 Proteins), (mu/I) large subunit, calpastatin (show CAST Proteins), and cathepsin D (show CTSD Proteins) genes with meat quality traits in double-muscled Piemontese cattle.
Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls.
The association of polymorphisms in calpastatin (show CAST Proteins) and mu-calpain genes with meat tenderness in 3 French beef breeds is reported.
CAPN1 HM535412:g.157T > C showed effect on meat redness.
The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.
catalytic site amino acid residues 105-133 contained a disulfide bond between Cys (show DNAJC5 Proteins)(108) and Cys (show DNAJC5 Proteins)(115)
Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.
The activities of Calpain and PLA2 (show YWHAZ Proteins) on the muscle tissue of the bladders were analyzed.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain, large polypeptide L1
, cell proliferation-inducing gene 30 protein
, cell proliferation-inducing protein 30
, micromolar calcium activated neutral protease 1
, micromolar calcium-activated neutral protease 1
, mu-calpain large subunit