Browse our CAPNL1 Proteins (CAPNL1)

Full name:
Calpain 1, Large Subunit Proteins (CAPNL1)
On are 17 Calpain 1, Large Subunit (CAPNL1) Proteins from 5 different suppliers available. Additionally we are shipping CAPNL1 Antibodies (56) and CAPNL1 Kits (18) and many more products for this protein. A total of 104 CAPNL1 products are currently listed.
CANP, CANP1, CANPL1, Capa-1, Capa1, mu-calpin, muCANP, muCL, si:ch211-203k12.4, si:dkeyp-101g1.3
list all proteins Gene Name GeneID UniProt
CAPNL1 12333 O35350
CAPNL1 823 P07384
CAPNL1 29153 P97571

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CAPNL1 Proteins (CAPNL1) by Origin

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More Proteins for CAPNL1 Interaction Partners

Mouse (Murine) Calpain 1, Large Subunit (CAPNL1) interaction partners

  1. High calpain expression is associated with brain injury.

  2. the expression of the full-length 60-kDa calcineurin (show PPP3CA Proteins) protein is down-regulated due to over-activated calpain that cleaves calcineurin (show PPP3CA Proteins) to form a 45-kDa fragment.

  3. calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.

  4. Attenuation of atherosclerotic lesions/inflammation in ApoE (show APOE Proteins) KO mice by simvastatin might be associated with the downregulation of CD36 (show CD36 Proteins) and calpain-1 (show CAPN1 Proteins).

  5. Leukocyte calpain-1 (show CAPN1 Proteins)/calpain-2 (show CAPN2 Proteins) deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.

  6. TnT3 regulates transcription of Cacna1s (show CACNA1S Proteins), the gene encoding Cav1.1 (show CACNA1S Proteins). Knocking down TnT3 in vivo downregulated Cav1.1 (show CACNA1S Proteins).

  7. Taken together, our findings suggested that DHRS7C maintains intracellular Ca(2+) homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca(2+) overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation

  8. In conclusion, calpain was involved in oxygen glucose deprivation-induced RGC-5 necroptosis with the increased expression of its downstream molecule tAIF.

  9. CRYbetaA3/A1-crystallin has a role in preventing nuclear cataract impaired lysosomal cargo clearance and calpain activation

  10. Capn1 protein and activity in mitochondria were elevated in diabetic mouse hearts. Increased mitochondrial Capn1 was associated with increased mitochondrial ROS (show ROS1 Proteins) generation and oxidative damage and reduced ATP5A1 (show ATP5A1 Proteins) protein and ATP synthase activity.

Human Calpain 1, Large Subunit (CAPNL1) interaction partners

  1. HRNR (show HRNR Proteins) deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (show CAPN1 Proteins).

  2. calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.

  3. calpain and protein kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins) abnormal release promotes a constitutive release of matrix metalloproteinase 9 (show MMP9 Proteins) in peripheral blood mononuclear cells from cystic fibrosis (show S100A8 Proteins) patients

  4. our findings suggest that the gene/protein expression of both CAPN1 and CAPN2 (show CAPN2 Proteins), as well as the ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.

  5. This study demonstrated that Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.

  6. the calpain-dependent cleavage of Nav1.6 (show SCN8A Proteins) channels expressed in human embryonic kidney (HEK (show EPHA3 Proteins)) 293 cells caused the upregulation of I(NaP (show CTNNBL1 Proteins))

  7. Increased mu-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.

  8. Data indicate that calpain is responsible for processing translation termination factor eRF3 into its IAP-binding isoform p-eRF3.

  9. NOS (show NOS1 Proteins) stimulation via PI3K (show PIK3CA Proteins), calpain proteases, and SIRT1 (show SIRT1 Proteins)-dependent deacetylation downstream from VEGFR2 (show KDR Proteins) activation contributes to these vasodilator responses.

  10. Junctophilin-2 (show JPH2 Proteins) is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 (show JPH2 Proteins) truncations.

Cow (Bovine) Calpain 1, Large Subunit (CAPNL1) interaction partners

  1. This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.

  2. Suppression of CANP1 resulted in the activation of caspase (show CASP3 Proteins) and heat-shock-protein systems which might in turn regulate apoptosis through the caspase (show CASP3 Proteins)-dependent cell death pathway. [CANP1]

  3. bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures

  4. This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Proteins) as a selection marker for beef quality.

  5. It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.

  6. m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.

  7. Association of polymorphisms in calpain 1 (show CAPN1 Proteins), (mu/I) large subunit, calpastatin (show CAST Proteins), and cathepsin D (show CTSD Proteins) genes with meat quality traits in double-muscled Piemontese cattle.

  8. Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls.

  9. The association of polymorphisms in calpastatin (show CAST Proteins) and mu-calpain genes with meat tenderness in 3 French beef breeds is reported.

  10. A new insertion/deletion (InDel) polymorphism, consisting of a change of seven nucleotides for only one nucleotide (TCTGGGT --> C) within intron 17 of the CAPN1 gene, is reported.

Pig (Porcine) Calpain 1, Large Subunit (CAPNL1) interaction partners

  1. CAPN1 HM535412:g.157T > C showed effect on meat redness.

  2. The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.

  3. Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.

  4. catalytic site amino acid residues 105-133 contained a disulfide bond between Cys (show DNAJC5 Proteins)(108) and Cys (show DNAJC5 Proteins)(115)

  5. Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.

Rabbit Calpain 1, Large Subunit (CAPNL1) interaction partners

  1. The activities of Calpain and PLA2 (show YWHAZ Proteins) on the muscle tissue of the bladders were analyzed.

CAPNL1 Protein Profile

Protein Summary

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with CAPNL1

  • calpain 1, (mu/I) large subunit (capn1)
  • calpain 1, (mu/I) large subunit b (capn1b)
  • calpain 1 (Capn1)
  • calpain 1, (mu/I) large subunit (CAPN1)
  • calpain 1, (mu/I) large subunit (Capn1)
  • CANP protein
  • CANP1 protein
  • CANPL1 protein
  • Capa-1 protein
  • Capa1 protein
  • mu-calpin protein
  • muCANP protein
  • muCL protein
  • si:ch211-203k12.4 protein
  • si:dkeyp-101g1.3 protein

Protein level used designations for CAPNL1

calpain 1, large subunit , CANP 1 , calcium-activated neutral proteinase 1 , calpain mu-type , calpain-1 catalytic subunit , calpain-1 large subunit , micromolar-calpain , mu-calpain , muCANP , calpain, large polypeptide L1 , cell proliferation-inducing gene 30 protein , cell proliferation-inducing protein 30 , micromolar calcium activated neutral protease 1 , micromolar calcium-activated neutral protease 1 , mu-calpain large subunit

380177 Xenopus laevis
541454 Xenopus (Silurana) tropicalis
565106 Danio rerio
12333 Mus musculus
823 Homo sapiens
281661 Bos taurus
397027 Sus scrofa
100009089 Oryctolagus cuniculus
29153 Rattus norvegicus
693249 Gallus gallus
100174090 Pongo abelii
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