Browse our anti-Caspase 1 (CASP1) Antibodies

Full name:
anti-Caspase 1 Antibodies (CASP1)
On www.antibodies-online.com are 280 Caspase 1 (CASP1) Antibodies from 33 different suppliers available. Additionally we are shipping Caspase 1 Kits (57) and Caspase 1 Proteins (35) and many more products for this protein. A total of 393 Caspase 1 products are currently listed.
Synonyms:
CASP1, ccp1, CG5370, dcp-1, dcp1, Dmel\\CG5370, Ice, Il1bc, l(2)01862, l(2)02132, P45
list all antibodies Gene Name GeneID UniProt
CASP1 834 P29466
CASP1 12362 P29452
CASP1 25166  

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Most Popular Reactivities for anti-Caspase 1 (CASP1) Antibodies

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anti-Human Caspase 1 Antibodies:

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anti-Rat (Rattus) Caspase 1 Antibodies:

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Top referenced anti-Caspase 1 Antibodies

  1. Human Monoclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN252521 : Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007 (PubMed)
    Show all 24 references for 252521

  2. Human Monoclonal Caspase 1 Primary Antibody for IHC (p), ELISA - ABIN393212 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for 393212

  3. Human Polyclonal Caspase 1 Primary Antibody for IF, IP - ABIN222877 : Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006 (PubMed)
    Show all 5 references for 222877

  4. Dog (Canine) Monoclonal Caspase 1 Primary Antibody for IF, WB - ABIN968350 : Akiyama, Yokota, Kagawa, Shimbara, DeMartino, Slaughter, Noda, Tanaka: cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. in FEBS letters 1995 (PubMed)
    Show all 3 references for 968350

  5. Human Polyclonal Caspase 1 Primary Antibody for ELISA, WB - ABIN1536100 : Thornberry, Bull, Calaycay, Chapman, Howard, Kostura, Miller, Molineaux, Weidner, Aunins: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. in Nature 1992 (PubMed)
    Show all 3 references for 1536100

  6. Human Polyclonal Caspase 1 Primary Antibody for IHC, ELISA - ABIN1532666 : Feng, Li, Leung, Auersperg: Caspase-1zeta, a new splice variant of the caspase-1 gene. in Genomics 2004 (PubMed)
    Show all 3 references for 1532666

  7. Human Polyclonal Caspase 1 Primary Antibody for IHC, ELISA - ABIN1531644 : Agostini, Martinon, Burns, McDermott, Hawkins, Tschopp: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. in Immunity 2004 (PubMed)
    Show all 3 references for 1531644

  8. Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN115381 : Walker, Talanian, Brady, Dang, Bump, Ferenz, Franklin, Ghayur, Hackett, Hammill: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. in Cell 1994 (PubMed)
    Show all 2 references for 115381

  9. Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288006 : Kariya, Okano, Zhao, Kataoka, Yoshinobu, Maeda, Ishihara, Higaki, Nishizaki: Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. in Acta oto-laryngologica 2016 (PubMed)

More Antibodies against Caspase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 1 (CASP1) interaction partners

  1. drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Antibodies) but not dcp-1 (show ACE Antibodies), but required drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) when drICE (show CASP3 Antibodies) activity was reduced via hypomorphic mutation.

  2. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Antibodies), and ice

  3. Autophagy suppresses Dcp-1 (show ACE Antibodies)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Antibodies) positively regulates autophagy, possibly through feedback regulation.

  4. novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Antibodies) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Antibodies) and/or pita during mid-oogenesis

  5. A double-mutant analysis between drICE (show CASP3 Antibodies) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Antibodies), reveals that some cells (type I) strictly require drICE (show CASP3 Antibodies) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Antibodies) or dcp-1 (show ACE Antibodies).

  6. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (show BIRC2 Antibodies) Bruce (show BIRC6 Antibodies) function to regulate both autophagy and starvation-induced cell death in Drosophila.

  7. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Antibodies), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.

Silk Worm Caspase 1 (CASP1) interaction partners

  1. cBm-IAP1 (show BIRC3 Antibodies) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.

  2. Activation of Atg5 (show ATG5 Antibodies), AIF (show AIFM1 Antibodies) and caspase (show CASP3 Antibodies) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.

Mouse (Murine) Caspase 1 (CASP1) interaction partners

  1. The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (show IL1B Antibodies) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.

  2. Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.

  3. Inflammasome NLRP3 (show NLRP3 Antibodies)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  4. Data indicate that NLRC4 (show NLRC4 Antibodies) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Antibodies) release, and implicate Caspase-8 (show CASP8 Antibodies) in NLRC4 (show NLRC4 Antibodies) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8 (show CASP8 Antibodies).

  5. our studies have uncovered a specific role for caspase-1-mediated IL-1beta (show IL1B Antibodies) release in the manifestation of Familial Mediterranean Fever (show MEFV Antibodies)

  6. variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1beta (show IL1B Antibodies)-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2 (show ARHGDIG Antibodies), receptor interacting protein (show RIPK1 Antibodies) kinase 2 (show PKC Antibodies)), which is further amplified through pyroptosome and cell division.

  7. TNF-alpha (show TNF Antibodies) induces caspase-1 activation in an inflammasome-independent manner in 3T3-L1 cells and that the ERK (show EPHB2 Antibodies)-dependent expression of NLRP3 (show NLRP3 Antibodies) may play a role independently of its canonical role as a component of inflammasomes.

  8. caspase-1 activation is an upstream event of apoptotic caspase-7 (show CASP7 Antibodies) induction in renal tubulointerstitial fibrosis

  9. it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS (show TLR4 Antibodies) and reduced LPS (show TLR4 Antibodies)-induced IL-1beta (show IL1B Antibodies) production through inhibition of Caspase 1 activation.

  10. Study suggests that Casp1 has a limited role in the development of burn-induced pain.

Human Caspase 1 (CASP1) interaction partners

  1. Proteases caspase-1 and caspase-8 (show CASP8 Antibodies) have redundant roles in cleaving IL-1beta (show IL1B Antibodies) and promoting osteomyelitis. [review]

  2. Patients with NLRP1 (show NLRP1 Antibodies)-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.

  3. The biochemical function of NLPR3 inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) and the induction of pyroptosis, a form of cell death. (Review)

  4. The structure of the human caspase-1 CARD domain (caspase-1(CARD)) filament solved by cryo-electron microscopy.

  5. Caspase-1-mediated downregulation of PPARgamma (show PPARG Antibodies) was important in the late stage of monocyte-macrophage differentiation; however, PPARgamma (show PPARG Antibodies) protein levels had little effect on the early stage differentiation.

  6. Inflammasome NLRP3 (show NLRP3 Antibodies)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  7. Study demonstrates that the expression of the NLRP3 (show NLRP3 Antibodies)-caspase-1-IL-18 (show IL18 Antibodies) axis is highly expressed in the peripheral blood mononuclear cells of patients with bullous pemphigoid (show DST Antibodies) (BP), and correlated with disease activity, suggesting its involvement in the pathogenesis and progression of BP.

  8. High expression of CASP1 is associated with osteosarcoma.

  9. This study demonstrated that dysregulated expression of NLRP3 (show NLRP3 Antibodies)-caspase-1-IL-1beta (show IL1B Antibodies) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  10. The NLRP3 (show NLRP3 Antibodies)/caspase-1/IL-1beta (show IL1B Antibodies) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

Pig (Porcine) Caspase 1 (CASP1) interaction partners

  1. Src kinase (show CSK Antibodies) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

  2. endometrial expression of CASP1 and IL18 (show IL18 Antibodies) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Antibodies) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy

Caspase 1 (CASP1) Antigen Profile

Antigen Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 1 (CASP1)

  • caspase 1, apoptosis-related cysteine peptidase (CASP1) antibody
  • caspase 1 (Casp1) antibody
  • caspase 4, apoptosis-related cysteine peptidase (CASP4) antibody
  • Death caspase-1 (Dcp-1) antibody
  • caspase-1 (Ice) antibody
  • caspase-1 (AaeL_AAEL014348) antibody
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1) antibody
  • caspase-1-like (LOC100725217) antibody
  • caspase 1 (LOC100101588) antibody
  • CASP1 antibody
  • ccp1 antibody
  • CG5370 antibody
  • dcp-1 antibody
  • dcp1 antibody
  • Dmel\\CG5370 antibody
  • Ice antibody
  • Il1bc antibody
  • l(2)01862 antibody
  • l(2)02132 antibody
  • P45 antibody

Protein level used designations for anti-Caspase 1 (CASP1) Antibodies

CASP1 nirs variant 1 , IL-1 beta-converting enzyme , IL1B-convertase , caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) , caspase-1 , interleukin 1, beta, convertase , interleukin 1-B converting enzyme , CASP-1 , IL-1B converting enzyme , IL-1BC , interleukin 1 beta-converting enzyme , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , Interleukin 1beta converting enzyme , caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) , ICE , interleukin-1 beta converting enzyme , caspase-1/caspase-4 hybrid , CG5370-PA , Dcp-1-PA , caspase , caspase 1 , death caspase-1

GENE ID SPECIES
834 Homo sapiens
12362 Mus musculus
25166 Rattus norvegicus
395764 Gallus gallus
397319 Sus scrofa
403724 Canis lupus familiaris
37729 Drosophila melanogaster
692604 Bombyx mori
5564196 Aedes aegypti
100033888 Equus caballus
451519 Pan troglodytes
514214 Bos taurus
100437679 Pongo abelii
100588974 Nomascus leucogenys
706568 Macaca mulatta
100725217 Cavia porcellus
100101588 Oryctolagus cuniculus
493961 Felis catus
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