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anti-Human Caspase 1 Antibodies:
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Human Monoclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN252521
Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007
Show all 24 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3044293
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy. in Neural regeneration research 2015
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3043221
Huang, Huang, Xiao, Yang, Lin, Diao: Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway. in Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie 2014
Show all 21 Pubmed References
Mouse (Murine) Polyclonal Caspase 1 Primary Antibody for WB - ABIN5518669
Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury. in Neural regeneration research 2014
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IF, IP - ABIN222877
Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006
Show all 5 Pubmed References
Dog (Canine) Monoclonal Caspase 1 Primary Antibody for IF, WB - ABIN968350
Akiyama, Yokota, Kagawa, Shimbara, DeMartino, Slaughter, Noda, Tanaka: cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. in FEBS letters 1995
Show all 3 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288002
Draganov, Gopalakrishna-Pillai, Chen, Zuckerman, Moeller, Wang, Ann, Lee: Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. in Scientific reports 2015
Show all 3 Pubmed References
Human Monoclonal Caspase 1 Primary Antibody for IHC (p), ELISA - ABIN560170
Choi, Stottmann, Yang, Meyers, Klingensmith: The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. in Circulation research 2007
Show all 2 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288006
Kariya, Okano, Zhao, Kataoka, Yoshinobu, Maeda, Ishihara, Higaki, Nishizaki: Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. in Acta oto-laryngologica 2016
Human Polyclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN4287999
Dumas, Amiable, de Rivero Vaccari, Chae, Keane, Lacroix, Vallières: The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. in PLoS pathogens 2014
the activation of Rho GTPases by the CNF1 toxin during E. coli-triggered bacteremia leads to a GR1(+)cell-mediated efficient bacterial clearing and improves host survival. Host alarm requires the Caspase-1/IL-1beta (show IL1B Antibodies) signaling axis.
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
sickle red blood cell induced TLR9 (show TLR9 Antibodies), NLRP3 (show NLRP3 Antibodies), Caspase-1, IL-1beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) expression and induced IL-1beta (show IL1B Antibodies), LTB4 (show PTGR1 Antibodies) and nitrite production in PBMC cultures.
Data show that the serine protease inhibitor B9 (serpinB9 (show SERPINB9 Antibodies)) mediated caspase-1 inhibition regulates IL-1beta (show IL1B Antibodies) release in monocytes.
study uncovers a novel mechanism of G9A (show EHMT2 Antibodies) promoting tumor cell growth and invasion by silencing CASP1, and implies that G9A (show EHMT2 Antibodies) may serve as a therapeutic target in treating Non-small-cell lung cancer.
Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment.
besides its role in the inhibition of the NF-kappaB (show NFKB1 Antibodies) pathway, NLRC3 (show NLRC3 Antibodies) interferes with the assembly and activity of the NALP3 (show NLRP3 Antibodies) inflammasome complex by competing with ASC (show PYCARD Antibodies) for pro-caspase-1 binding
Data, including data from studies using recombinant fusion forms of GSDMD (gasdermin D (show GSDMD Antibodies)), suggest that GSDMD (show GSDMD Antibodies) participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD (show GSDMD Antibodies) by caspase-1 and caspase-11 (show CASP4 Antibodies).
Proteases caspase-1 and caspase-8 (show CASP8 Antibodies) have redundant roles in cleaving IL-1beta (show IL1B Antibodies) and promoting osteomyelitis. [review]
Patients with NLRP1 (show NLRP1 Antibodies)-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.
Adult neural stem cells (ANSCs) expressed NLRP3 (show NLRP3 Antibodies)-containing inflammasome and alpha-syn activated both TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and NLRP3 (show NLRP3 Antibodies)/caspase-1 signals in ANSCs.
dimerized or endogenous caspase-8 (show CASP8 Antibodies) can also directly cleave IL-1beta (show IL1B Antibodies) into its biologically active form, in the absence of canonical inflammasome components.
Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1/IL-1beta (show IL1B Antibodies) pathway.
caspase-1-/- mice exhibited resistance to indomethacin-induced small intestinal damage
data provide evidence that the NLRC4 (show NLRC4 Antibodies) inflammasome contributes to resistance through regulation of caspase-1, IL-1beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) in a CD11blowLy6Glow population of cells
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4 (show TLR4 Antibodies), which activates Nlrp3 (show NLRP3 Antibodies), and subsequently induces caspase-1 activation.
The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (show IL1B Antibodies) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.
Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.
Inflammasome NLRP3 (show NLRP3 Antibodies)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.
Src kinase (show CSK Antibodies) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (show IL18 Antibodies) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Antibodies) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Antibodies) but not dcp-1 (show ACE Antibodies), but required drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) when drICE (show CASP3 Antibodies) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Antibodies), and ice
Autophagy suppresses Dcp-1 (show ACE Antibodies)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Antibodies) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Antibodies) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Antibodies) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (show CASP3 Antibodies) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Antibodies), reveals that some cells (type I) strictly require drICE (show CASP3 Antibodies) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Antibodies) or dcp-1 (show ACE Antibodies).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (show BIRC2 Antibodies) Bruce (show BIRC6 Antibodies) function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Antibodies), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (show BIRC3 Antibodies) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (show ATG5 Antibodies), AIF (show AIFM1 Antibodies) and caspase (show CASP3 Antibodies) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1