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Browse our anti-Caspase 1 (CASP1) Antibodies

Full name:
anti-Caspase 1 Antibodies (CASP1)
On are 284 Caspase 1 (CASP1) Antibodies from 31 different suppliers available. Additionally we are shipping Caspase 1 Kits (48) and Caspase 1 Proteins (35) and many more products for this protein. A total of 387 Caspase 1 products are currently listed.
CASP1, ccp1, CG5370, dcp-1, dcp1, Dmel\\CG5370, ICE, IL1BC, l(2)01862, l(2)02132, P45
list all antibodies Gene Name GeneID UniProt
CASP1 12362 P29452
CASP1 25166  
CASP1 834 P29466

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Most Popular Reactivities for anti-Caspase 1 (CASP1) Antibodies

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anti-Mouse (Murine) Caspase 1 Antibodies:

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anti-Human Caspase 1 Antibodies:

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Top referenced anti-Caspase 1 Antibodies

  1. Human Monoclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN252521 : Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007 (PubMed)
    Show all 23 references for ABIN252521

  2. Human Monoclonal Caspase 1 Primary Antibody for IHC (p), ELISA - ABIN393212 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN393212

  3. Human Polyclonal Caspase 1 Primary Antibody for IF, IP - ABIN222877 : Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006 (PubMed)
    Show all 5 references for ABIN222877

  4. Human Polyclonal Caspase 1 Primary Antibody for EIA, IHC (p) - ABIN499543 : Gracie, Robertson, McInnes: Interleukin-18. in Journal of leukocyte biology 2003 (PubMed)
    Show all 4 references for ABIN499543

  5. Dog (Canine) Monoclonal Caspase 1 Primary Antibody for IF, WB - ABIN968350 : Akiyama, Yokota, Kagawa, Shimbara, DeMartino, Slaughter, Noda, Tanaka: cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. in FEBS letters 1995 (PubMed)
    Show all 3 references for ABIN968350

  6. Human Polyclonal Caspase 1 Primary Antibody for IHC, ELISA - ABIN1532666 : Thornberry, Bull, Calaycay, Chapman, Howard, Kostura, Miller, Molineaux, Weidner, Aunins: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. in Nature 1992 (PubMed)
    Show all 3 references for ABIN1532666

  7. Human Polyclonal Caspase 1 Primary Antibody for ELISA, WB - ABIN1536100 : Cerretti, Kozlosky, Mosley, Nelson, Van Ness, Greenstreet, March, Kronheim, Druck, Cannizzaro: Molecular cloning of the interleukin-1 beta converting enzyme. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 3 references for ABIN1536100

  8. Human Polyclonal Caspase 1 Primary Antibody for IHC, ELISA - ABIN1531644 : Feng, Li, Leung, Auersperg: Caspase-1zeta, a new splice variant of the caspase-1 gene. in Genomics 2004 (PubMed)
    Show all 3 references for ABIN1531644

  9. Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN115381 : Walker, Talanian, Brady, Dang, Bump, Ferenz, Franklin, Ghayur, Hackett, Hammill: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. in Cell 1994 (PubMed)
    Show all 2 references for ABIN115381

  10. Human Polyclonal Caspase 1 Primary Antibody for EIA, IHC (p) - ABIN499541 : Martinon, Tschopp: Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. in Cell 2004 (PubMed)

More Antibodies against Caspase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 1 (CASP1) interaction partners

  1. drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Antibodies) but not dcp-1 (show ACE Antibodies), but required drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) when drICE (show CASP3 Antibodies) activity was reduced via hypomorphic mutation.

  2. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Antibodies), and ice

  3. Autophagy suppresses Dcp-1 (show ACE Antibodies)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Antibodies) positively regulates autophagy, possibly through feedback regulation.

  4. novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Antibodies) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Antibodies) and/or pita during mid-oogenesis

  5. A double-mutant analysis between drICE (show CASP3 Antibodies) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Antibodies), reveals that some cells (type I) strictly require drICE (show CASP3 Antibodies) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Antibodies) or dcp-1 (show ACE Antibodies).

  6. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (show BIRC2 Antibodies) Bruce (show BIRC6 Antibodies) function to regulate both autophagy and starvation-induced cell death in Drosophila.

  7. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Antibodies), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.

Silk Worm Caspase 1 (CASP1) interaction partners

  1. Activation of Atg5 (show ATG5 Antibodies), AIF (show AIFM1 Antibodies) and caspase (show CASP3 Antibodies) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.

Mouse (Murine) Caspase 1 (CASP1) interaction partners

  1. Data show that inhibiting caspase-1 activity in the NLR (show CXCR5 Antibodies) family, pyrin domain-containing 3 protein (NLRP3 (show NLRP3 Antibodies)) inflammasome decreased gastric cell apoptosis.

  2. Chronic kidney disease-mediated increase of contractile markers in vascular smooth muscle cells and increased expression of VSMC migration molecule alphavbeta3 integrin in NH formation were caspase-1 dependent.

  3. Demonstrate the utility of intracellular caspase 1 and extracellular CTSS (show CTSS Antibodies) proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.

  4. Caspase-11 (show CASP4 Antibodies) targets cofilin (show CFL1 Antibodies) via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase

  5. Caspase-1-/- mice have intact immune responses but do not develop an expanded marginal zone B cell population in response to pristane-induced lupus. This may be one explanation for reduced IgG autoantibody production in these mice.

  6. study uncovered an important role for YopJ in inhibiting caspase-1 in activated macrophages and in promoting Yersinia virulence

  7. Caspase-1-activated IL-18 (show IL18 Antibodies) induces IFN-gamma (show IFNG Antibodies) to prime caspase-11 (show CASP4 Antibodies) and rapidly clear Burkholderia thailandensis infection.

  8. These results argue that caspase-1, -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases

  9. The resilience of casp1(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 (show ADAMTS1 Antibodies) gene expression.

  10. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 (show CASP8 Antibodies) Inflammasomes.

Human Caspase 1 (CASP1) interaction partners

  1. This study demonstrated that dysregulated expression of NLRP3 (show NLRP3 Antibodies)-caspase-1-IL-1beta (show IL1B Antibodies) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  2. The NLRP3 (show NLRP3 Antibodies)/caspase-1/IL-1beta (show IL1B Antibodies) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

  3. High expression of NLRP3 (show NLRP3 Antibodies), NLRC4 (show NLRC4 Antibodies), and CASP1 in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  4. The proteins of NLRP3 (show NLRP3 Antibodies), ASC (show PYCARD Antibodies), and caspase-1 were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

  5. The results indicate that acteoside may act as a regulator of the IL-32 (show IL32 Antibodies) induced immune responses.

  6. These results suggest that released caspase-1 exists in a unique complex that is functionally stable and protected from immunodepletion whereas cell-extract generated active caspase-1 is rapidly inhibited in the cytosolic milieu.

  7. Genetic polymorphisms in Nalp3 (show NLRP3 Antibodies) and caspase-1 may be associated with individual susceptibility to silicosis, especially when the polymorphisms interact with age, cumulative dust exposure, or smoking status.

  8. In contrast, inhibition of the protease activity of Kgp, RgpA or RgpB increased the human caspase-1-activating potential of wild-type Porphyromonas gingivalis, indicating an inhibitory effect of the collaborative action of gingipains.

  9. NLRP3 (show NLRP3 Antibodies) and caspase-1 are expressed in the odontoblast layers in normal human dental pulp tissue, whereas in inflamed pulp tissue, the odontoblast layers are disrupted and dental pulp cells are positive for NLRP3 (show NLRP3 Antibodies) and caspase-1.

  10. the rs713875 IBD risk polymorphism increases MTMR3 (show MTMR3 Antibodies) expression, which modulates pattern recognition receptor (PRR (show PVRL1 Antibodies))-induced outcomes, including increased induced caspase-1 activation

Pig (Porcine) Caspase 1 (CASP1) interaction partners

  1. Src kinase (show CSK Antibodies) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

  2. endometrial expression of CASP1 and IL18 (show IL18 Antibodies) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Antibodies) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy

Caspase 1 (CASP1) Antigen Profile

Antigen Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 1 (CASP1)

  • Death caspase-1 (Dcp-1) antibody
  • caspase-1 (Ice) antibody
  • caspase-1 (AaeL_AAEL014348) antibody
  • caspase 1 (Casp1) antibody
  • caspase 1 (LOC100101588) antibody
  • caspase 1, apoptosis-related cysteine peptidase (CASP1) antibody
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1) antibody
  • caspase 4, apoptosis-related cysteine peptidase (CASP4) antibody
  • caspase-1-like (LOC100725217) antibody
  • CASP1 antibody
  • ccp1 antibody
  • CG5370 antibody
  • dcp-1 antibody
  • dcp1 antibody
  • Dmel\\CG5370 antibody
  • ICE antibody
  • IL1BC antibody
  • l(2)01862 antibody
  • l(2)02132 antibody
  • P45 antibody

Protein level used designations for anti-Caspase 1 (CASP1) Antibodies

CG5370-PA , Dcp-1-PA , caspase , caspase 1 , caspase-1 , death caspase-1 , CASP-1 , IL-1 beta-converting enzyme , IL-1B converting enzyme , IL-1BC , interleukin 1 beta-converting enzyme , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , Interleukin 1beta converting enzyme , interleukin 1, beta, convertase , CASP1 nirs variant 1 , IL1B-convertase , caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) , interleukin 1-B converting enzyme , ICE , interleukin-1 beta converting enzyme , caspase-1/caspase-4 hybrid , caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)

37729 Drosophila melanogaster
692604 Bombyx mori
5564196 Aedes aegypti
12362 Mus musculus
25166 Rattus norvegicus
100101588 Oryctolagus cuniculus
834 Homo sapiens
397319 Sus scrofa
493961 Felis catus
100033888 Equus caballus
395764 Gallus gallus
514214 Bos taurus
403724 Canis lupus familiaris
100725217 Cavia porcellus
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