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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)||Human|
|ELISA||12 Antibodies||18 Antibodies||100 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies||1 Antibodies|
|Immunofluorescence (IF)||5 Antibodies||5 Antibodies|
|Immunohistochemistry (IHC)||13 Antibodies||17 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||6 Antibodies||7 Antibodies|
|Immunoprecipitation (IP)||7 Antibodies||9 Antibodies|
|Western Blotting (WB)||25 Antibodies||41 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||6 Antibodies|
|Antigen||Caspase 1 (CASP1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Caspase 1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 1 AntibodyTarget Details Caspase 1 Application Details Handling References for anti-Caspase 1 Antibody (ABIN222877) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412645|
|Specificity||The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.|
|Immunogen||Synthetic peptide surrounding amino acid 132 of human caspase-1|
Target Details Caspase 1Product Details anti-Caspase 1 Antibody Application Details Handling References for anti-Caspase 1 Antibody (ABIN222877) Images back to top
|Alternative Name||Caspase-1 (CASP1 Antibody Abstract)|
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
Synonyms: CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE
Application DetailsProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling References for anti-Caspase 1 Antibody (ABIN222877) Images back to top
|Application Notes||Western blot analysis (0.5-4 μg/mL), Immunoprecipitation (4-8 μg/mL) and Immunofluorescence (10-20 μg/mL).|
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details References for anti-Caspase 1 Antibody (ABIN222877) Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit anti-caspase-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-Caspase 1 Antibody (ABIN222877)Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling Images back to top
|Product cited in:||
Shi, Wang, Li et al.: "Neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1β production in keratinocytes." in: Anesthesia and analgesia, Vol. 113, Issue 1, pp. 175-83, 2011 (PubMed). (1:200).
Martin, Shaw, Liu et al.: "Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, Vol. 63, Issue 5, pp. 1322-32, 2011 (PubMed).
Martin, Shaw, Liu et al.: "MSU crystal-recruited non-inflammatory monocytes differentiate into M1-like pro-inflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, 2011 (PubMed).
Peluffo, Bussmann, Stouffer et al.: "Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle." in: Reproduction (Cambridge, England), Vol. 132, Issue 3, pp. 465-75, 2006 (PubMed).
Sasaki, Ikeda, Sato et al.: "Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis." in: The American journal of pathology, Vol. 169, Issue 3, pp. 831-45, 2006 (PubMed).
ImagesProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 Antibody (ABIN222877) back to top