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anti-Human Caspase 10 Antibodies:
anti-Mouse (Murine) Caspase 10 Antibodies:
anti-Rat (Rattus) Caspase 10 Antibodies:
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Human Monoclonal Caspase 10 Primary Antibody for WB - ABIN2688866
Fernandes-Alnemri, Armstrong, Krebs, Srinivasula, Wang, Bullrich, Fritz, Trapani, Tomaselli, Litwack, Alnemri: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 2 Pubmed References
Chicken Polyclonal Caspase 10 Primary Antibody for WB - ABIN153034
Park, Park, Kim, Kim, Park, Hwang, Jin, Jeong, Lee, Kim, Kim, Cho: Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax. in Biochemical and biophysical research communications 2012
Human Polyclonal Caspase 10 Primary Antibody for IHC, IHC (p) - ABIN4258288
Krajewska, Rosenthal, Mikolajczyk, Stennicke, Wiesenthal, Mai, Naito, Salvesen, Reed, Fiskum, Krajewski: Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. in Experimental neurology 2004
Human Polyclonal Caspase 10 Primary Antibody for ELISA, WB - ABIN1001994
Vincenz, Dixit: Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. in The Journal of biological chemistry 1997
Show all 3 Pubmed References
Caspase-10 is a negative regulator of cell death and a facilitator of gene induction separates the function of cFLIP (show CFLAR Antibodies) and caspase-10 in the death-inducing signaling complex.
caspase-10 was dispensable for enhancement of cisplatin/LA-12 and TRAIL combination-induced cell death and stimulation of Bid (show BID Antibodies) cleavage
This study reveals an essential role of SUMOylated FADD (show FADD Antibodies) in Drp1 (show CRMP1 Antibodies)- and caspase-10-dependent necrosis.
Three cases of autoimmune lymphoproliferative syndrome due to somatic FAS (show FAS Antibodies) mutation (ALPS-sFAS) combined with a germline CASP10 variation have been described.
Levels of caspase-9 (show CASP9 Antibodies), caspase-10, MAVS (show MAVS Antibodies), and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in the systemic lupus erythematosus patients were determined.
Results showed miR (show MLXIP Antibodies)-221/222 promote cell proliferation and repress apoptosis, through suppressing caspase-10, in prostate cancer cells.
We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (show CASP9 Antibodies) and CASP10) or different (CASP2 (show CASP2 Antibodies)) in the liver
proinflammatory (caspase 1 (show CASP1 Antibodies)) and initiator (caspases 8 and 10) caspases in the syncytiotrophoblast and capillary endotheliocytes of the terminal villi are higher in induced pregnancies.
Single nucleotide polymorphisms in CASP10 gene is associated with gastric cancer.
While myeloma cells require a basal level of autophagy for survival, caspase-10 tempers this response to avoid cell death.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, caspase 10, apoptosis-related cysteine protease
, FADD-like ICE2
, FAS-associated death domain protein interleukin-1B-converting enzyme 2
, ICE-like apoptotic protease 4
, apoptotic protease MCH-4
, interleukin-1B-converting enzyme 2