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Browse our anti-Caspase 2 (CASP2) Antibodies

Full name:
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase Antibodies (CASP2)
On www.antibodies-online.com are 199 Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies from 33 different suppliers available. Additionally we are shipping Caspase 2 Kits (25) and Caspase 2 Proteins (21) and many more products for this protein. A total of 256 Caspase 2 products are currently listed.
Synonyms:
CASP-2, Caspase-2, ICH-1, ICH-1L/1S, ICH1, ICH1L1S, NEDD-2, NEDD2, PPP1R57, xCaspase-2
list all antibodies Gene Name GeneID UniProt
CASP2 64314 P55215
CASP2 12366 P29594
CASP2 835 P42575

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Most Popular Reactivities for anti-Caspase 2 (CASP2) Antibodies

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anti-Rat (Rattus) Caspase 2 Antibodies:

anti-Mouse (Murine) Caspase 2 Antibodies:

anti-Human Caspase 2 Antibodies:

All available anti-Caspase 2 Antibodies

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Top referenced anti-Caspase 2 Antibodies

  1. Human Monoclonal Caspase 2 Primary Antibody for IF, WB - ABIN968323 : Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN968323

  2. Human Polyclonal Caspase 2 Primary Antibody for EIA, IF - ABIN499559 : Gracie, Robertson, McInnes: Interleukin-18. in Journal of leukocyte biology 2003 (PubMed)
    Show all 4 references for ABIN499559

  3. Mouse (Murine) Polyclonal Caspase 2 Primary Antibody for EIA, WB - ABIN118007 : Cohen: Caspases: the executioners of apoptosis. in The Biochemical journal 1997 (PubMed)
    Show all 4 references for ABIN118007

  4. Human Polyclonal Caspase 2 Primary Antibody for FACS, IHC (p) - ABIN388122 : Shi, Vivian, Lee, Ge, Morotomi-Yano, Manzl, Bock, Sato, Tomomori-Sato, Zhu, Haug, Swanson, Washburn, Chen, Chen, Villunger, Florens, Du: DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. in Cell 2009 (PubMed)
    Show all 3 references for ABIN388122

  5. Human Polyclonal Caspase 2 Primary Antibody for IHC, WB - ABIN222882 : Basu, Adkins, Basu: Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. in Cancer research 2008 (PubMed)
    Show all 2 references for ABIN222882

  6. Human Polyclonal Caspase 2 Primary Antibody for ELISA, WB - ABIN1536101 : Wang, Miura, Bergeron, Zhu, Yuan: Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. in Cell 1994 (PubMed)
    Show all 2 references for ABIN1536101

  7. Human Polyclonal Caspase 2 Primary Antibody for ELISA, WB - ABIN1536102 : Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: The DNA sequence of human chromosome 7. ... in Nature 2003 (PubMed)
    Show all 2 references for ABIN1536102

  8. Human Polyclonal Caspase 2 Primary Antibody for IHC (p), WB - ABIN1105674 : Bergeron, Perez, Macdonald, Shi, Sun, Jurisicova, Varmuza, Latham, Flaws, Salter, Hara, Moskowitz, Li, Greenberg, Tilly, Yuan: Defects in regulation of apoptosis in caspase-2-deficient mice. in Genes & development 1998 (PubMed)
    Show all 2 references for ABIN1105674

More Antibodies against Caspase 2 Interaction Partners

Xenopus laevis Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. caspase-2 has a role as an initiator caspase (show CASP3 Antibodies) in lipoapoptosis

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Antibodies) and Caspases-2 and -8

  3. Caspase-2 phosphorylated at S135 binds 14-3-3zeta (show YWHAZ Antibodies), thus preventing C2 dephosphorylation.

  4. The data demonstrate that cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, cdk1 (show CDK1 Antibodies)-cyclin B1 (show CCNB1 Antibodies) activity must be overcome for apoptosis to occur.

Mouse (Murine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein (show HOMER1 Antibodies) Raidd (show CRADD Antibodies)

  2. Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells.

  3. Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (show NLRX1 Antibodies) (NLRP3 (show NLRP3 Antibodies))-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation.

  4. these studies elucidate a Caspase-2-p53 (show TP53 Antibodies) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  5. data strongly suggest that caspase-2 deficiency leads to increased cellular stress largely because these mice fail to respond to oxidative stress by upregulating their antioxidant defense mechanism

  6. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.

  7. Caspase-2 is not a suppressor in MYCN (show MYCN Antibodies)-induced neuroblastoma (show ARHGEF16 Antibodies) and suggest a tissue and context-specific role for caspase-2 in tumorigenesis.

  8. our data point to a critical and novel role for caspase-2 in maintaining bone homeostasis by modulating ROS (show ROS1 Antibodies) levels and osteoclast apoptosis during conditions of enhanced oxidative stress that occur during aging

  9. Report the novel finding that CASP2 is an endogenous repressor of autophagy. Knockout or knockdown of CASP2 resulted in upregulation of autophagy in a variety of cell types and tissues.

  10. Caspase-2 activation is one of the few early molecular events identified in Parkinson disease models.

Human Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. these studies elucidate a Caspase-2-p53 (show TP53 Antibodies) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  2. We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (show CASP9 Antibodies) and CASP10 (show CASP10 Antibodies)) or different (CASP2) in the liver

  3. the initiator caspase-2 is required for robust death of ovarian cancer cells induced by FASN (show FASN Antibodies) inhibitors

  4. HuR (show ELAVL1 Antibodies) sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by upregulating the translation of caspase-2.

  5. Authors have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence.

  6. Data strongly argue against a critical role for caspase-2 in ER-stress-induced apoptosis.

  7. axon regeneration promoted by suppression of CASP2 and CASP6 (show CASP6 Antibodies) is CNTF (show CNTF Antibodies)-dependent and mediated through the JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signalling pathway

  8. Our results reveal a novel mechanism of caspase-2 pre-mRNA splicing.

  9. TRIM16 (show TRIM16 Antibodies) can promote apoptosis by directly modulating caspase-2 activity in cancer cells.

  10. The role of caspase-2 isoforms in the progression of breast cancer may considerably differ between pre- and post-chemotherapy patients.

Cow (Bovine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. EtOH-induced mitochondria-mediated apoptosis is initiated by caspase-2 activation, which is regulated by CoQ10

  2. the capacity for blastocysts to undergo further development is related to degree of group II caspase (show CASP3 Antibodies) activity

Caspase 2 (CASP2) Antigen Profile

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Caspase 2 (CASP2)

  • caspase-2-like (LOC100050611) antibody
  • caspase-2 (xCaspase-2) antibody
  • caspase-2 (CpipJ_CPIJ008254) antibody
  • caspase 2 (Casp2) antibody
  • caspase 2 (LOC100101590) antibody
  • caspase 2, apoptosis-related cysteine peptidase (CASP2) antibody
  • caspase 2, apoptosis-related cysteine peptidase (Casp2) antibody
  • caspase-2-like (LOC100521118) antibody
  • CASP-2 antibody
  • Caspase-2 antibody
  • ICH-1 antibody
  • ICH-1L/1S antibody
  • ICH1 antibody
  • ICH1L1S antibody
  • NEDD-2 antibody
  • NEDD2 antibody
  • PPP1R57 antibody
  • xCaspase-2 antibody

Protein level used designations for CASP2

caspase-2 , CASP-2 , ICH-1 protease , protease ICH-1 , NEDD-2 , neural precursor cell expressed developmentally down-regulated protein 2 , protein phosphatase 1, regulatory subunit 57 , caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) , ICH1 protease , caspase 2, apoptosis-related cysteine protease , cysteine protease caspase-2

GENE ID SPECIES
100050611 Equus caballus
397817 Xenopus laevis
6040179 Culex quinquefasciatus
64314 Rattus norvegicus
12366 Mus musculus
100101590 Oryctolagus cuniculus
835 Homo sapiens
482737 Canis lupus familiaris
531419 Bos taurus
395857 Gallus gallus
100735399 Cavia porcellus
100521118 Sus scrofa
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