anti-Human Caspase 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Caspase 2 Antibody (supplied by: Log in to see )

Antigen
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
  • xCaspase-2
  • Caspase-2
  • ICH-1
  • Nedd2
  • CASP-2
  • ICH1
  • NEDD-2
  • NEDD2
  • PPP1R57
  • ICH-1L/1S
  • ICH1L1S
  • caspase-2-like
  • caspase-2
  • caspase 2
  • caspase 2, apoptosis-related cysteine peptidase
  • LOC100050611
  • xCaspase-2
  • CpipJ_CPIJ008254
  • Casp2
  • LOC100101590
  • CASP2
  • LOC100521118
Epitope
C-Term
27
22
13
9
7
5
5
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
212
91
68
10
8
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
159
51
13
Clonality
Polyclonal
Conjugate
This Caspase 2 antibody is un-conjugated
6
6
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
182
101
48
35
18
15
13
12
12
4
4
4
2
1
Supplier
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Catalog No. ABIN1105674
$ 313.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.569977 ABIN784297 IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN388122 FACS IHC (p) WB Rabbit Ig AA 198-226, Center Log in to see Polyclonal 3
1 ABIN303201 IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN2879042 IHC (p) ELISA WB Rabbit IgG AA 123-172 Log in to see Polyclonal
1 ABIN317792 EIA IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN214432 ICC IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN1804091 IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN1493064 IHC (p) WB Rabbit C-Term Log in to see Polyclonal
1 ABIN769060 IHC (p) WB Rabbit IgG2b, kappa Log in to see Polyclonal
1 ABIN714980 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
1 ABIN2477911 IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN714973 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
1 ABIN714971 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN4288067 ICC IF IHC IHC (p) Rabbit Log in to see Polyclonal
1 ABIN609265 IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN1493070 IHC (p) IP WB Magnetic Particles Rabbit C-Term Log in to see Polyclonal
1 ABIN1493071 IHC (p) IP WB Sepharose Rabbit C-Term Log in to see Polyclonal
1 ABIN1732649 IHC (p) ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal
1 ABIN2892642 IHC (p) WB Rabbit Lys136 Log in to see Polyclonal
1 ABIN2883563 ELISA IHC (p) Rabbit IgG pSer157 Log in to see Polyclonal

General

Antigen Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
Epitope C-Term
(27), (22), (13), (9), (7), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(212), (91), (68), (10), (8), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(159), (51), (13)
Clonality
Polyclonal
Conjugate This Caspase 2 antibody is un-conjugated
(6), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(182), (101), (48), (35), (18), (15), (13), (12), (12), (4), (4), (4), (2), (1)
Pubmed 2 references available
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Product Details anti-Caspase 2 Antibody

Target Details Caspase 2 Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674) Images
Specificity This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human, Rat.
Purification Immunoaffinity Chromatography
Immunogen Synthetic peptide mapping at the C-terminal of Human Caspase 2 .Remarks: Sequence is identical to the related Rat and Mouse sequence.
Isotype IgG

Target Details Caspase 2

Product Details anti-Caspase 2 Antibody Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674) Images back to top
Antigen
Alternative Name Caspase-2 (CASP2 Antibody Abstract)
Background Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2
Gene ID 835
NCBI Accession NP_116764
UniProt P42575
Research Area Apoptosis/Necrosis, Cancer, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway

Application Details

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674) Images back to top
Reconstitution 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674)

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
Background publications

Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, 2004

Bergeron, Perez, Macdonald, Shi, Sun, Jurisicova, Varmuza, Latham, Flaws, Salter, Hara, Moskowitz, Li, Greenberg, Tilly, Yuan: "Defects in regulation of apoptosis in caspase-2-deficient mice." in: Genes & development, Vol. 12, Issue 9, pp. 1304-14, 1998

Images

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN1105674) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (C-Term) antibody (ABIN1105674) Caspase 2 Polyclonal Antibody