Browse our Caspase 3 Proteins (CASP3)

On www.antibodies-online.com are 47 Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Proteins from 10 different suppliers available. Additionally we are shipping Caspase 3 Antibodies (645) and Caspase 3 Kits (98) and many more products for this protein. A total of 845 Caspase 3 products are currently listed.
Synonyms:
A830040C14Rik, AC-3, Apopain, Cas3, Casp 3, Casp3, caspase-3, caspase 3, CC3, CG7788, CG14902, CPP32, CPP32B, crice, Decay, Dmel\\CG7788, Dmel\\CG14902, drice, Drosophila executioner caspase related to Apopain/Yama, ice, Lice, mldy, SCA-1, xcpp32, Yama
list all proteins Gene Name GeneID UniProt
CASP3 12367 P70677
CASP3 25402 P55213
CASP3 836 P42574

Caspase 3 Proteins (CASP3) by Origin

More Proteins for Caspase 3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.

  2. drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death.

  3. Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition.

  4. The cleaved DIAP1 (show DIAPH1 Proteins) binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.

  5. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice

  6. Data suggest that the cleaved-Caspase-3 antibody recognizes multiple proteins including DCP-1 (show ACE Proteins) and likely DRICE, but also at least one additional unknown protein, all of which require DRONC for epitope exposure.

  7. The caspase effector DRICE is activated during apoptosis in both mid- and late oogenesis; however, active DRICE was found more ubiquitously and at a higher level during germline cell death in midoogenesis.

  8. examination of inhibition by DIAP1 (show DIAPH1 Proteins)

  9. Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.

  10. A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1 (show ACE Proteins).

Mouse (Murine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. ULK1 (show ULK1 Proteins) is a novel substrate of Caspase-3 and upregulation of ULK1 (show ULK1 Proteins) drives autophagy initiation in leukemia cells.

  2. These results indicate that the caspase-3/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.

  3. report that mutating the caspase-3 consensus site in the EAAT2 (show SLC1A2 Proteins) sequence with an aspartate to asparagine mutation

  4. These studies suggest a link between Bik (show BIK Proteins)-mediated caspase activation and cleavage of viral proteins.

  5. melatonin could inhibit TLR4 (show TLR4 Proteins) expression in hypoxic microglia followed by suppression of caspase3 activation leading to decrease in production of proinflammatory mediators

  6. A significant emergence of GFP-expressing PCs and interneurons in symptomatic, but not non-symptomatic, SCA1 (show ATXN1 Proteins) mice 2 weeks after the MSC (show MSC Proteins) injection.

  7. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Proteins)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Proteins) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

  8. cognitive decline was significantly correlated with increased levels of caspase activity and tau truncated by caspase-3

  9. this study shows that Le Carbone, a charcoal supplement, attenuates experimental colitis through caspase 3 dependent apoptotic pathways

  10. Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 (show CASP9 Proteins) and caspase-3/7, in a dose-dependent fashion.

Human Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. cleaved caspase-3 and caspase-3/8/9 could be biomarkers for tumorigenesis in oral tongue squamous cell carcinoma patients.

  2. TT genotype of CASP3 rs4643701 polymorphisms showed risk in CAD. CASP3 rs4647601 creates a new exon splicing enhancer.

  3. These findings shed some light on how a tumor cell may avert apoptosis using Hsp60 (show HSPD1 Proteins) and point to the anti-cancer potential of drugs, such as CubipyOXA, which interfere with Hsp60 (show HSPD1 Proteins)/pC3 (show PCSK1 Proteins) complex formation, and thus allow the apoptotic cascade to proceed.

  4. Here the authors show that in macrophages SipA induces increased caspase-3 activation early in infection.

  5. SASH1 (show SASH1 Proteins) is cleaved by caspase-3 following Ultraviolet C-induced apoptosis.

  6. Caspase 3 activation in dying glioma cells unfavorably supported post-irradiation angiogenesis.

  7. Bcl-xL (show BCL2L1 Proteins) is an exosomal caspase-3 substrate and that this processing is required for the uptake of exosomes by recipient cells.

  8. CASP3 is a direct target of specific Epstein-Barr virus BART (show BSND Proteins) miRNAs.

  9. Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (show STAT1 Proteins)/2 induced by IFN-beta (show IFNB1 Proteins), but p-STAT1 (show STAT1 Proteins)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 (show KPNA1 Proteins) and induces degradation of cellular KPNA1 (show KPNA1 Proteins) via caspase-3. [EV17 = Enterovirus 71]

  10. our results identified that mammalian sterile 20-like kinase 1 (show STK4 Proteins) is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 (show STK4 Proteins) by enhancing Caspase-3-dependent cleavage.

Cow (Bovine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 (show BCL2 Proteins) protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle.

  3. Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos.

  4. mRNA expression of Bax (show BAX Proteins), Bcl-2 (show BCL2 Proteins), caspase-3 and-7 cannot be used as a reliable apoptosis detection method.

  5. the capacity for blastocysts to undergo further development is related to degree of group II caspase activity

  6. Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity.

Pig (Porcine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. This study demonstrated that LAMPs from M. hyopneumoniae can induce apoptosis in St. Jude porcine lung epithelial cell line through the activation of caspase 3, caspase 8 (show CASP8 Proteins), cyt c (show CYCS Proteins), Bax (show BAX Proteins), and p38 MAPK (show MAPK14 Proteins).

  2. Caspase-3 (CC3) was shown to be more abundant in early-cleaving and more developmentally competent embryos compared to late-cleaving and less developmentally competent embryos.

  3. Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3- and caspase-9 (show CASP9 Proteins)-dependent mitochondrial pathway.

  4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 and BDNF (show BDNF Proteins)

  5. both caspase-3-dependent and -independent pathways of programmed cell death increased upon Salmonella typhimurium infection.

  6. clonidine administration prior to hypoxia prevents the hypoxia-induced increase in the activity of caspase-3 in the cerebral cortex.

  7. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 (show TP53 Proteins) expression and caspase-3 activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed

  8. Ischemic preconditioning exerts a powerful protective effect against hepatic ischemia-reperfusion injury in the early phase of reperfusion, which may be mediated by preservation of mitochondrial structure and inhibition of caspase-3 activity.

Rabbit Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 expression as well as low Bcl-2 (show BCL2 Proteins) expression.

  2. This study revealed that the 810-nm low-level laser can improve cartilage structure, prevent articular cartilage degradation and significantly decrease the expression of caspase-3 in this surgery-induced osteoarthritis model.

  3. Morphine hypoxic preconditioning can protect rabbits against acute kidney hypoxic/reoxygenation injury by decreasing expression of caspase-3.

  4. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 (show BCL2 Proteins) and down-regulating the activation of caspase-3.

  5. High frequency oscillatory ventilation combined with exogenous pulmonary surfactant can decrease the concentration of caspase-3 and p73 (show ARHGAP24 Proteins) rabbit with acute respiratory failure.

Xenopus laevis Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1 (show MAPK8 Proteins)-2 and Bid (show BID Proteins).

  2. in the developing diencephalon, Caspase3 acts downstream of Barhl2 (show BARHL2 Proteins) in limiting neuroepithelial cell proliferation by inhibiting beta-catenin (show CTNNB1 Proteins) activation.

  3. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53 (show TP53 Proteins)-dependent and p53 (show TP53 Proteins)-independent apoptosis during development.

Caspase 3 (CASP3) Protein Profile

Protein Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Alternative names and synonyms associated with Caspase 3 (CASP3)

  • caspase 3, apoptosis-related cysteine peptidase (CASP3)
  • death executioner caspase related to Apopain/Yama (decay)
  • CG7788 gene product from transcript CG7788-RA (Ice)
  • caspase 3 (Casp3)
  • caspase 3, apoptosis-related cysteine peptidase (Casp3)
  • caspase 3, apoptosis-related cysteine peptidase (casp3)
  • A830040C14Rik protein
  • AC-3 protein
  • Apopain protein
  • Cas3 protein
  • Casp 3 protein
  • Casp3 protein
  • caspase-3 protein
  • caspase 3 protein
  • CC3 protein
  • CG7788 protein
  • CG14902 protein
  • CPP32 protein
  • CPP32B protein
  • crice protein
  • Decay protein
  • Dmel\\CG7788 protein
  • Dmel\\CG14902 protein
  • drice protein
  • Drosophila executioner caspase related to Apopain/Yama protein
  • ice protein
  • Lice protein
  • mldy protein
  • SCA-1 protein
  • xcpp32 protein
  • Yama protein

Protein level used designations for CASP3

Caspase-3-like protein , caspase-3 , CG14902-PA , Caspase-3 , caspase 3 , caspase-3 protein , cleaved caspase 3 , decay-PA , CG7788-PA , Ice-PA , drice , interleukin-1beta-converting enzyme , CASP-3 , CPP-32 , SCA-1 , SREBP cleavage activity 1 , caspase 3, apoptosis related cysteine protease , cysteine protease CPP32 , protein Yama , CPP32beta , Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease) , Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease) , IRP , apopain , yama protein , PARP cleavage protease , caspase 3, apoptosis-related cysteine protease , procaspase3

GENE ID SPECIES
100034083 Equus caballus
42008 Drosophila melanogaster
43514 Drosophila melanogaster
12367 Mus musculus
25402 Rattus norvegicus
836 Homo sapiens
408016 Bos taurus
403567 Canis lupus familiaris
397244 Sus scrofa
443031 Ovis aries
100008840 Oryctolagus cuniculus
395476 Gallus gallus
100718309 Cavia porcellus
493932 Felis catus
397720 Xenopus laevis
461669 Pan troglodytes
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