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Browse our Caspase 3 Proteins (CASP3)

Full name:
Caspase 3, Apoptosis-Related Cysteine Peptidase Proteins (CASP3)
On are 42 Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Proteins from 11 different suppliers available. Additionally we are shipping Caspase 3 Antibodies (530) and Caspase 3 Kits (98) and many more products for this protein. A total of 725 Caspase 3 products are currently listed.
A830040C14Rik, AC-3, Apopain, Cas3, Casp 3, Casp3, caspase-3, caspase 3, CC3, CG7788, CG14902, CPP32, CPP32B, crice, Decay, Dmel\\CG7788, Dmel\\CG14902, drice, Drosophila executioner caspase related to Apopain/Yama, ice, Lice, mldy, SCA-1, xcpp32, Yama
list all proteins Gene Name GeneID UniProt
CASP3 12367 P70677
CASP3 25402 P55213
CASP3 836 P42574

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Caspase 3 Proteins (CASP3) by Origin

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Top referenced Caspase 3 Proteins

  1. Human Caspase 3 Protein expressed in Escherichia coli (E. coli) - ABIN413120 : Basu, Lu, Sun, Moor, Akkaraju, Huang: Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals. in The Journal of biological chemistry 2002 (PubMed)
    Show all 17 references for ABIN413120

  2. Human Caspase 3 Protein expressed in Escherichia coli (E. coli) - ABIN413129 : Pianu, Lefort, Thuiliere, Tabourier, Bartolini: The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau. in Journal of cell science 2014 (PubMed)

  3. Human Caspase 3 Protein expressed in Escherichia coli (E. coli) - ABIN2001969 : Harrington, Ho, Ghosh, Tung: Construction and analysis of a modular model of caspase activation in apoptosis. in Theoretical biology & medical modelling 2009 (PubMed)

More Proteins for Caspase 3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death.

  2. Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition.

  3. The cleaved DIAP1 (show DIAPH1 Proteins) binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.

  4. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice

  5. Data suggest that the cleaved-Caspase-3 antibody recognizes multiple proteins including DCP-1 (show ACE Proteins) and likely DRICE, but also at least one additional unknown protein, all of which require DRONC for epitope exposure.

  6. The caspase effector DRICE is activated during apoptosis in both mid- and late oogenesis; however, active DRICE was found more ubiquitously and at a higher level during germline cell death in midoogenesis.

  7. examination of inhibition by DIAP1 (show DIAPH1 Proteins)

  8. Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.

  9. A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1 (show ACE Proteins).

  10. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process

Mouse (Murine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. expression level of miR (show MLXIP Proteins)-98, which can regulate Caspase-3, was significantly decreased. Huwe1, the host gene of miR (show MLXIP Proteins)-98, was positively associated with miR (show MLXIP Proteins)-98 expression after Silica NP exposure

  2. administration of 0.3 IU/mL FSH (show BRD2 Proteins) during ovarian cryopreservation by vitrification can maintain ovarian survival during ovarian vitrification and increases the blood supply with avascular transplantation via upregulation of Cx43 (show GJA1 Proteins), Cx37 (show GJA4 Proteins), and VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins)

  3. indicates that the up-regulation of ROCK1 (show ROCK1 Proteins) activity in RhoA (show RHOA Proteins)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 and are sensitive to Caspase-3 inhibition

  4. that caspase-3-mediated nuclear opening formation accompanied by histone release from the opening is a critical step toward chromatin condensation during erythropoiesis in mice

  5. The influence of chronic ethanol consumption on the expression of the Bdnf (show BDNF Proteins), Bax (show BAX Proteins), Bcl-xL (show BCL2L1 Proteins), and CASP3 genes was studied in the brain structures of B6-1473C (C/C) and B6-1473G (G/G) mice that had been obtained on the base of the C57BL/6 strain.

  6. MicroRNA-124 and microRNA-137 cooperatively control caspase-3 activity through BCL2L13 (show BCL2L13 Proteins) in hippocampal neural stem cells.

  7. impaired mTORC1-Homer-3 (show HOMER3 Proteins) activity underlies PC susceptibility in Spinocerebellar ataxia (show USP14 Proteins) type 1 and presents a promising therapeutic target

  8. GSAP (show PION Proteins) cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase (show ALOX5 Proteins) in Alzheimer's disease.

  9. The study demonstrates sublethal caspase-activation has an important role in cardiomyocyte differentiation and may have significant implications for promoting cardiac regeneration after myocardial injury involving exogenous or endogenous cell sources.

  10. Parkinson disease induction increased the expression of the apoptotic mediators p53 (show TP53 Proteins) and active caspase-3 in gastrocnemius muscle.

Human Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Cleaved caspase-3 expression was a predictor of biochemical progression in prostate cancer patients.

  2. In addition to acting as a key executioner in apoptosis, caspase 3 in dying tumor cells may play a central role in driving proangiogenic response after irradiation.

  3. Caspase-3 mainly degraded LMP1 (show PDLIM7 Proteins) proteins in HeLa cells, leading to decreased NF-kappaB (show NFKB1 Proteins) and STAT3 (show STAT3 Proteins) activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1 (show PDLIM7 Proteins).

  4. in vitro OGT (show OGT Proteins) knockdown induced more cell apoptosis through increasing PUMA (show BBC3 Proteins) and caspase-3 expression

  5. increased production of vascular endothelial growth factor by mesenchymal stromal cells facilitating AKT (show AKT1 Proteins) phosphorylation and inhibiting caspase 3-mediated apoptosis

  6. FANCJ protein is important for the stability of FANCD2/FANCI (show FANCI Proteins) proteins and protects them from proteasome and caspase-3 dependent degradation.

  7. Increased miR (show MLXIP Proteins)-451 expression may negatively regulate Bcl-2 (show BCL2 Proteins) mRNA and protein expression, followed by affecting the protein expression of caspase 3, and accelerate the apoptosis in breast cancer

  8. Caspase-3-enhanced Bid (show BID Proteins) activation initiates the genistein induced cell death pathway.

  9. Low expression of CASP3 is associated with non-small cell lung cancer.

  10. HER2 (show ERBB2 Proteins) promotes tumor cell survival by inhibiting apoptosis i.e. by downregulating CASP-3 and CASP-8 (show CASP8 Proteins).

Cow (Bovine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 (show BCL2 Proteins) protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle.

  3. Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos.

  4. mRNA expression of Bax (show BAX Proteins), Bcl-2 (show BCL2 Proteins), caspase-3 and-7 cannot be used as a reliable apoptosis detection method.

  5. the capacity for blastocysts to undergo further development is related to degree of group II caspase activity

  6. Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity.

Pig (Porcine) Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. This study demonstrated that LAMPs from M. hyopneumoniae can induce apoptosis in St. Jude porcine lung epithelial cell line through the activation of caspase 3, caspase 8 (show CASP8 Proteins), cyt c (show CYCS Proteins), Bax (show BAX Proteins), and p38 MAPK (show MAPK14 Proteins).

  2. Caspase-3 (CC3) was shown to be more abundant in early-cleaving and more developmentally competent embryos compared to late-cleaving and less developmentally competent embryos.

  3. Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3- and caspase-9 (show CASP9 Proteins)-dependent mitochondrial pathway.

  4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 and BDNF (show BDNF Proteins)

  5. both caspase-3-dependent and -independent pathways of programmed cell death increased upon Salmonella typhimurium infection.

  6. clonidine administration prior to hypoxia prevents the hypoxia-induced increase in the activity of caspase-3 in the cerebral cortex.

  7. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 (show TP53 Proteins) expression and caspase-3 activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed

  8. Ischemic preconditioning exerts a powerful protective effect against hepatic ischemia-reperfusion injury in the early phase of reperfusion, which may be mediated by preservation of mitochondrial structure and inhibition of caspase-3 activity.

Rabbit Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. This study revealed that the 810-nm low-level laser can improve cartilage structure, prevent articular cartilage degradation and significantly decrease the expression of caspase-3 in this surgery-induced osteoarthritis model.

  2. Morphine hypoxic preconditioning can protect rabbits against acute kidney hypoxic/reoxygenation injury by decreasing expression of caspase-3.

  3. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 (show BCL2 Proteins) and down-regulating the activation of caspase-3.

  4. High frequency oscillatory ventilation combined with exogenous pulmonary surfactant can decrease the concentration of caspase-3 and p73 (show ARHGAP24 Proteins) rabbit with acute respiratory failure.

Xenopus laevis Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1 (show MAPK8 Proteins)-2 and Bid (show BID Proteins).

  2. in the developing diencephalon, Caspase3 acts downstream of Barhl2 (show BARHL2 Proteins) in limiting neuroepithelial cell proliferation by inhibiting beta-catenin (show CTNNB1 Proteins) activation.

  3. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53 (show TP53 Proteins)-dependent and p53 (show TP53 Proteins)-independent apoptosis during development.

Caspase 3 (CASP3) Protein Profile

Protein Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Alternative names and synonyms associated with Caspase 3 (CASP3)

  • caspase 3, apoptosis-related cysteine peptidase (CASP3)
  • death executioner caspase related to Apopain/Yama (decay)
  • CG7788 gene product from transcript CG7788-RA (Ice)
  • caspase 3 (Casp3)
  • caspase 3, apoptosis-related cysteine peptidase (Casp3)
  • caspase 3, apoptosis-related cysteine peptidase (casp3)
  • A830040C14Rik protein
  • AC-3 protein
  • Apopain protein
  • Cas3 protein
  • Casp 3 protein
  • Casp3 protein
  • caspase-3 protein
  • caspase 3 protein
  • CC3 protein
  • CG7788 protein
  • CG14902 protein
  • CPP32 protein
  • CPP32B protein
  • crice protein
  • Decay protein
  • Dmel\\CG7788 protein
  • Dmel\\CG14902 protein
  • drice protein
  • Drosophila executioner caspase related to Apopain/Yama protein
  • ice protein
  • Lice protein
  • mldy protein
  • SCA-1 protein
  • xcpp32 protein
  • Yama protein

Protein level used designations for CASP3

Caspase-3-like protein , caspase-3 , CG14902-PA , Caspase-3 , caspase 3 , caspase-3 protein , cleaved caspase 3 , decay-PA , CG7788-PA , Ice-PA , drice , interleukin-1beta-converting enzyme , CASP-3 , CPP-32 , SCA-1 , SREBP cleavage activity 1 , caspase 3, apoptosis related cysteine protease , cysteine protease CPP32 , protein Yama , CPP32beta , Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease) , Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease) , IRP , apopain , yama protein , PARP cleavage protease , caspase 3, apoptosis-related cysteine protease , procaspase3

100034083 Equus caballus
42008 Drosophila melanogaster
43514 Drosophila melanogaster
12367 Mus musculus
25402 Rattus norvegicus
836 Homo sapiens
408016 Bos taurus
403567 Canis lupus familiaris
397244 Sus scrofa
443031 Ovis aries
100008840 Oryctolagus cuniculus
395476 Gallus gallus
100718309 Cavia porcellus
493932 Felis catus
397720 Xenopus laevis
461669 Pan troglodytes
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