Browse our anti-Caspase 4 (CASP4) Antibodies

Full name:
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase Antibodies (CASP4)
On are 263 Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies from 30 different suppliers available. Additionally we are shipping Caspase 4 Kits (54) and Caspase 4 Proteins (25) and many more products for this protein. A total of 358 Caspase 4 products are currently listed.
CASP1, CASP4, Casp11, CASP13, Caspl, ICE(rel)II, ICEREL-II, ICH-2, ich-3, Mih1/TX, TX
list all antibodies Gene Name GeneID UniProt
CASP4 837 P49662
CASP4 12363 P70343
CASP4 114555  

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anti-Human Caspase 4 Antibodies:

anti-Mouse (Murine) Caspase 4 Antibodies:

anti-Rat (Rattus) Caspase 4 Antibodies:

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Top referenced anti-Caspase 4 Antibodies

  1. Human Monoclonal Caspase 4 Primary Antibody for ELISA, ICC - ABIN265762 : Kenneth, Younger, Hughes, Marcotte, Barker, Saunders, Duckett: An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. in The Biochemical journal 2012 (PubMed)
    Show all 21 references for 265762

  2. Human Polyclonal Caspase 4 Primary Antibody for IHC (p), WB - ABIN121890 : Cohen: Caspases: the executioners of apoptosis. in The Biochemical journal 1997 (PubMed)
    Show all 4 references for 121890

  3. Human Polyclonal Caspase 4 Primary Antibody for IHC (p), WB - ABIN3043186 : Ji, Yan, Li, Lai, Liu: Therapeutic effects of intrathecal versus intravenous monosialoganglioside against bupivacaine-induced spinal neurotoxicity in rats. in Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie 2015 (PubMed)
    Show all 2 references for 3043186

  4. Human Monoclonal Caspase 4 Primary Antibody for WB - ABIN967534 : Faucheu, Diu, Chan, Blanchet, Miossec, Hervé, Collard-Dutilleul, Gu, Aldape, Lippke: A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. in The EMBO journal 1995 (PubMed)
    Show all 2 references for 967534

  5. Mouse (Murine) Polyclonal Caspase 4 Primary Antibody for WB - ABIN222879 : Huang, Xie, Qiao, Qiu, Huang, Li, Chen, Liu, Wang, Lin, Wang: Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. in Toxicological sciences : an official journal of the Society of Toxicology 2015 (PubMed)

  6. Human Polyclonal Caspase 4 Primary Antibody for ELISA, WB - ABIN185284 : Munday, Vaillancourt, Ali, Casano, Miller, Molineaux, Yamin, Yu, Nicholson: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. in The Journal of biological chemistry 1995 (PubMed)

  7. Human Polyclonal Caspase 4 Primary Antibody for WB - ABIN222883 : Kim, Zhang, Hitomi, Lee, Mukherjee: Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. in Human molecular genetics 2006 (PubMed)

More Antibodies against Caspase 4 Interaction Partners

Human Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) interaction partners

  1. Pathophysiological studies showed that the overexpression of the CASP4 gene was involved in the loss of proximal tubules and renal injury in nephropathic cystinosis patients. Considering kidney's key roles in sodium filtration and reabsorption CASP4 genes are involved in Blood Pressure regulation.

  2. We propose that microglial caspase-4 expression contributes to the cognitive impairments in Alzheimer's disease (AD), and that further study of caspase-4 will enhance our understanding of AD pathogenesis and may lead to novel therapeutic targets in AD.

  3. this study shows that activation of caspase-4 is mediated by interactions with endotoxin-rich membrane interfaces rather than by endotoxin monomers

  4. Specific activation of caspase-3 (show CASP3 Antibodies) and caspase-4 was found in proplatelets. Consistent with previous observations of caspase-4 autoactivation in response to endoplasmic reticulum (ER) stress, several ER stress marker proteins were expressed during proplatelet formation.

  5. apoptosis is induced by rhein traditional Chinese medicine via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells

  6. Caspase-4 and caspase-5 (show CASP5 Antibodies) mediate IL-1alpha and IL-1beta (show IL1B Antibodies) release from human monocytes after lipopolysaccharides stimulation.

  7. both caspase-4 and caspase-5 (show CASP5 Antibodies) are functionally important for appropriate responses to intracellular Gram-negative bacteria.

  8. caspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 (show NLRP3 Antibodies) inflammasome activation to drive IL-1beta (show IL1B Antibodies) maturation.

  9. This study reveled that CASP4 having a central role in the bipolar disease and schizophrenia manifestation.

  10. NF-kappaB (show NFKB1 Antibodies) can mediate Fas (show FAS Antibodies)-induced apoptosis through caspase-4 protease

Mouse (Murine) Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) interaction partners

  1. Caspase-11 targets cofilin (show CFL1 Antibodies) via the RhoA GTPase, whereas caspase-1 (show CASP1 Antibodies) engages the Slingshot phosphatase

  2. Hyperactive dendritic cells induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxidized phospholipids and bacterial lipopolysaccharide.

  3. Caspase-1 (show CASP1 Antibodies)-activated IL-18 (show IL18 Antibodies) induces IFN-gamma (show IFNG Antibodies) to prime caspase-11 and rapidly clear Burkholderia thailandensis infection.

  4. These results argue that caspase-1 (show CASP1 Antibodies), -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases

  5. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation

  6. But not in Casp11(-/-), Panx1 (show PANX1 Antibodies)(-/-), or P2x7 (show P2RX7 Antibodies)(-/-) mice.

  7. active caspase-11 leads to a drop of intracellular potassium levels, which is necessary to activate NLRP3 (show NLRP3 Antibodies).

  8. Data show that caspase-1 (show CASP1 Antibodies) but not caspase-11 was essential for the functional activities of the NLRC4 (show NLRC4 Antibodies) inflammasome.

  9. Data indicate that genetic ablation of caspase-1 (show CASP1 Antibodies) and -11 from cpdm (show SHARPIN Antibodies) mice significantly reduced skin inflammation in sharpin (show SHARPIN Antibodies)-deficient mice.

  10. These results suggest a role for other caspase-11 effector mechanisms such as pyroptosis in protection against intestinal inflammation.

Caspase 4 (CASP4) Antigen Profile

Antigen Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 4 (CASP4)

  • caspase 4 (CASP4) antibody
  • caspase 11 (LOC100101589) antibody
  • caspase 4, apoptosis-related cysteine peptidase (CASP4) antibody
  • caspase 4, apoptosis-related cysteine peptidase (Casp4) antibody
  • caspase-4-like (LOC100359184) antibody
  • CASP1 antibody
  • CASP4 antibody
  • Casp11 antibody
  • CASP13 antibody
  • Caspl antibody
  • ICE(rel)II antibody
  • ICEREL-II antibody
  • ICH-2 antibody
  • ich-3 antibody
  • Mih1/TX antibody
  • TX antibody

Protein level used designations for CASP4

caspase 4 , CASP-4 , ICE(rel)-II , apoptotic cysteine protease Mih1/TX , caspase 4, apoptosis-related cysteine protease , caspase-4 , protease ICH-2 , protease TX , CASP-11 , caspase 11, apoptosis-related cysteine peptidase , caspase 11, apoptosis-related cysteine protease , caspase-11 short form splicing , protease ICH-3 , caspase 11 , CASP-1 , ICE , IL-1 beta-converting enzyme , IL-1BC , caspase-1 , caspase-1/caspase-4 hybrid , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , CASP-13 , ERICE , caspase 13 , caspase-13 , evolutionary related interleukin-1-beta-converting enzyme

704864 Macaca mulatta
100101589 Oryctolagus cuniculus
837 Homo sapiens
12363 Mus musculus
114555 Rattus norvegicus
403724 Canis lupus familiaris
338039 Bos taurus
100359184 Oryctolagus cuniculus
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