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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||148 Antibodies||51 Antibodies||19 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||34 Antibodies||14 Antibodies||4 Antibodies|
|Immunohistochemistry (IHC)||47 Antibodies||11 Antibodies||3 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies||4 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||3 Antibodies|
|Antigen||Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Caspase 4 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-Caspase 4 AntibodyTarget Details Caspase 4 Application Details Handling References for anti-Caspase 4 Antibody (ABIN222883) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412652|
|Specificity||The affinity purified antibody detects the 43 kDa proform of caspase-4.|
|Immunogen||Synthetic peptide surrounding amino acid 100 of human caspase-4|
Target Details Caspase 4Product Details anti-Caspase 4 Antibody Application Details Handling References for anti-Caspase 4 Antibody (ABIN222883) Images back to top
|Alternative Name||Caspase-4 (CASP4 Antibody Abstract)|
Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-4 is also known as Ich-2, TX, and ICErel-II and can proteolytically processed by granzyme B. Over expression of caspase-4 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.
Synonyms: CASP-4, ICH-2 protease, TX protease, ICH2
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling References for anti-Caspase 4 Antibody (ABIN222883) Images back to top
Western blot analysis (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details References for anti-Caspase 4 Antibody (ABIN222883) Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-Caspase 4 Antibody (ABIN222883)Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling Images back to top
|Product cited in:||
Kim, Zhang, Hitomi, Lee, Mukherjee: "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL." in: Human molecular genetics, Vol. 15, Issue 11, pp. 1826-34, 2006
ImagesProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 Antibody (ABIN222883) back to top