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|Antigen||Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies|
|Reactivity||Human, Monkey Alternatives|
|Conjugate||This Caspase 4 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Caspase 4 AntibodyTarget Details Caspase 4 Application Details Handling Images
|Specificity||The affinity purified antibody detects the 43 kDa proform of caspase-4.|
|Immunogen||Synthetic peptide surrounding amino acid 100 of human caspase-4|
Target Details Caspase 4Product Details anti-Caspase 4 Antibody Application Details Handling Images back to top
|Alternative Name||Caspase-4 (CASP4 Antibody Abstract)|
|Background||Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-4 is also known as Ich-2, TX, and ICErel-II and can proteolytically processed by granzyme B. Over expression of caspase-4 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling Images back to top
Western Blot: 0,5-4g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Images back to top
|Buffer||PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal|
|Precaution of Use||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||-20 °C/-80 °C|
|Storage Comment||Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.|
ImagesProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling back to top