Browse our anti-Caspase 6 (CASP6) Antibodies

Full name:
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase Antibodies (CASP6)
On www.antibodies-online.com are 316 Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) Antibodies from 30 different suppliers available. Additionally we are shipping Caspase 6 Kits (35) and Caspase 6 Proteins (16) and many more products for this protein. A total of 387 Caspase 6 products are currently listed.
Synonyms:
casp6, caspase-6, mCASP-6, MCH2, xCaspase-6, zgc:112960
list all antibodies Gene Name GeneID UniProt
CASP6 12368 O08738
CASP6 83584  
CASP6 839 P55212

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Most Popular Reactivities for anti-Caspase 6 (CASP6) Antibodies

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Top referenced anti-Caspase 6 Antibodies

  1. Human Monoclonal Caspase 6 Primary Antibody for WB - ABIN967553 : Cohen: Caspases: the executioners of apoptosis. in The Biochemical journal 1997 (PubMed)
    Show all 5 references for 967553

  2. Human Polyclonal Caspase 6 Primary Antibody for EIA, IHC (p) - ABIN358091 : Kalinin, Kalinin, Aho, Uitto, Aho: Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region. in The Journal of investigative dermatology 2005 (PubMed)
    Show all 5 references for 358091

  3. Human Monoclonal Caspase 6 Primary Antibody for WB - ABIN264405 : Orth, Chinnaiyan, Garg, Froelich, Dixit: The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. in The Journal of biological chemistry 1996 (PubMed)
    Show all 4 references for 264405

  4. Human Polyclonal Caspase 6 Primary Antibody for IHC (p), WB - ABIN657756 : Würstle, Laussmann, Rehm: The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for 657756

  5. Human Polyclonal Caspase 6 Primary Antibody for IHC (p), WB - ABIN388106 : MacLachlan, El-Deiry: Apoptotic threshold is lowered by p53 transactivation of caspase-6. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for 388106

  6. Human Polyclonal Caspase 6 Primary Antibody for IHC, WB - ABIN223017 : Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. in Nature 2009 (PubMed)
    Show all 2 references for 223017

  7. Human Polyclonal Caspase 6 Primary Antibody for IHC, ELISA - ABIN1536082 : Yashiro, Qiu, Hasegawa, Zhang, Matsuzaki, Hirakawa: An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells. in British journal of cancer 2011 (PubMed)

  8. Human Polyclonal Caspase 6 Primary Antibody for IHC (p), WB - ABIN389525 : Horowitz, Patterson, Guillozet-Bongaarts, Reynolds, Carroll, Weintraub, Bennett, Cryns, Berry, Binder: Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 (PubMed)

More Antibodies against Caspase 6 Interaction Partners

Mouse (Murine) Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) interaction partners

  1. caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies) expression in 4T1 tumor-associated macrophages

  2. Casp6 is unlikely to be involved in colitis-associated tumors.

  3. p53 (show TP53 Antibodies) activity is an important upstream regulator of caspase-6 activity in muscle tissue.

  4. TNFalpha (show TNF Antibodies)-induced RIP1 (show RALBP1 Antibodies)-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis.

  5. CASP6 released from axonal terminals regulates microglial TNF-alpha (show TNF Antibodies) secretion, synaptic plasticity, and inflammatory pain.

  6. both Caspase-3 (show CASP3 Antibodies) and Caspase-6 are implicated in axon degeneration that occurs as a part of normal development.

  7. Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume.

  8. This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt (show HTT Antibodies) proteolytic fragment in the brain.

  9. Neutrophil/macrophage contact activates CASP-6, producing interleukin-1 receptor-associated kinase-M (show IRAK3 Antibodies) (IRAK-M (show IRAK3 Antibodies)) cleavage and de-repression of alveolar macrophages; CASP-6 deletion protects mice from death caused by bacterial peritonitis.

  10. Lamin A/C (show LMNA Antibodies) and caspase-6 could be valuable tools in the knowledge of oocyte in vitro destiny

Human Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) interaction partners

  1. These data suggest that caspase-6 deactivating mutations may contribute to multifactorial carcinogenic transformations.

  2. Caspase-6 undergoes helix-strand transition upon substrate binding. Caspase-6 shows distinctive conformational dynamics in its 130's region Local pKa Values of Key Amino Acid Residues within the 130's Region Vary between the Unliganded (Helical) and the VEID-bound (Strand) States of Caspase-6 .

  3. Following specific binding to and internalization into HER2 (show ERBB2 Antibodies)-overexpressing tumor cells, the e23sFv-Fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of HER2 (show ERBB2 Antibodies)-overexpressing A172 and U251MG cells in vitro, but not in U87MG cells with undetectable HER2 (show ERBB2 Antibodies)

  4. Results identified novel members of the CASP6 interactome and demonstrate that a number of them are involved in key signaling pathways observed in neurodegenerative diseases.

  5. The ability of sox11 (show SOX11 Antibodies) to reduce effector caspase (show CASP3 Antibodies) activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox (show PIPOX Antibodies) proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 (show SOX11 Antibodies)

  6. Caspase-6 plays a role in activating caspase-3 (show CASP3 Antibodies) in Tau truncation.

  7. unmodified STAT1 (show STAT1 Antibodies) is cleaved at multiple sites by caspase-3 (show CASP3 Antibodies) and caspase-6 in malignant undifferentiated hematopoietic cells

  8. p53 (show TP53 Antibodies) activity is an important upstream regulator of caspase-6 activity in Huntington's disease.

  9. In this study, the crystal structure of a full-length CASP6 zymogen mutant, proCASP6H121A, was solved.

  10. Caspase-6 is likely important in most tissues during early development but is less involved in adult tissues

Caspase 6 (CASP6) Antigen Profile

Antigen Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.

Alternative names and synonyms associated with Caspase 6 (CASP6)

  • caspase 6, apoptosis-related cysteine peptidase (casp6) antibody
  • caspase 6 (CASP6) antibody
  • caspase-6 (CpipJ_CPIJ017008) antibody
  • Caspase-6 (casp6) antibody
  • caspase 6 (Casp6) antibody
  • caspase 6 (LOC100341546) antibody
  • caspase 6, apoptosis-related cysteine peptidase (CASP6) antibody
  • caspase 6, apoptosis-related cysteine peptidase (Casp6) antibody
  • caspase-6-like (LOC100517293) antibody
  • casp6 antibody
  • caspase-6 antibody
  • mCASP-6 antibody
  • MCH2 antibody
  • xCaspase-6 antibody
  • zgc:112960 antibody

Protein level used designations for CASP6

caspase-6 , caspase 6, apoptosis-related cysteine protease , caspase-6a , caspase 6 , Caspase-6 , CASP-6 , apoptotic protease Mch-2 , apoptotic protease MCH-2

GENE ID SPECIES
397818 Xenopus laevis
496478 Xenopus (Silurana) tropicalis
552927 Danio rerio
768261 Felis catus
6050542 Culex quinquefasciatus
100305305 Oncorhynchus mykiss
12368 Mus musculus
83584 Rattus norvegicus
100341546 Oryctolagus cuniculus
839 Homo sapiens
538409 Bos taurus
487899 Canis lupus familiaris
395477 Gallus gallus
100713360 Cavia porcellus
101119820 Ovis aries
100517293 Sus scrofa
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