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Coletti, Yang, Marazzi, Sassoon: TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways. in The EMBO journal 2002
Show all 2 references for ABIN411850
Doostzadeh-Cizeron, Yin, Goodrich: Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-kappa B activation. in The Journal of biological chemistry 2000
Show all 2 references for ABIN411854
Casp6 is unlikely to be involved in colitis-associated tumors.
p53 (show TP53 ELISA Kits) activity is an important upstream regulator of caspase-6 activity in muscle tissue.
TNFalpha (show TNF ELISA Kits)-induced RIP1 (show RALBP1 ELISA Kits)-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis.
CASP6 released from axonal terminals regulates microglial TNF-alpha (show TNF ELISA Kits) secretion, synaptic plasticity, and inflammatory pain.
both Caspase-3 (show CASP3 ELISA Kits) and Caspase-6 are implicated in axon degeneration that occurs as a part of normal development.
Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume.
This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt (show HTT ELISA Kits) proteolytic fragment in the brain.
Neutrophil/ma (show IRAK3 ELISA Kits)crophage contact activates CASP-6, producing interleukin-1 receptor-associated kinase-M (IRAK-M) cleavage and de-repression of alveolar macrophages; CASP-6 deletion protects mice from death caused by bacterial peritonitis.
Lamin A/C (show LMNA ELISA Kits) and caspase-6 could be valuable tools in the knowledge of oocyte in vitro destiny
p53 (show TP53 ELISA Kits) activation enhances XIAP (show XIAP ELISA Kits) inhibition-induced cell death by promoting mitochondrial release of second mitochondria-derived activator of caspases (SMAC (show DIABLO ELISA Kits)) and by inducing the expression of caspase-6.
Results identified novel members of the CASP6 interactome and demonstrate that a number of them are involved in key signaling pathways observed in neurodegenerative diseases.
The ability of sox11 (show SOX11 ELISA Kits) to reduce effector caspase (show CASP3 ELISA Kits) activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox (show PIPOX ELISA Kits) proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 (show SOX11 ELISA Kits)
Caspase-6 plays a role in activating caspase-3 (show CASP3 ELISA Kits) in Tau truncation.
unmodified STAT1 (show STAT1 ELISA Kits) is cleaved at multiple sites by caspase-3 (show CASP3 ELISA Kits) and caspase-6 in malignant undifferentiated hematopoietic cells
p53 (show TP53 ELISA Kits) activity is an important upstream regulator of caspase-6 activity in Huntington's disease.
In this study, the crystal structure of a full-length CASP6 zymogen mutant, proCASP6H121A, was solved.
Caspase-6 is likely important in most tissues during early development but is less involved in adult tissues
axon regeneration promoted by suppression of CASP2 (show CASP2 ELISA Kits) and CASP6 is CNTF (show CNTF ELISA Kits)-dependent and mediated through the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signalling pathway
Significant associations have been found between CpG sites and patient sex, including DNA methylation (show HELLS ELISA Kits) in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12 (show HSD17B12 ELISA Kits), which encodes a sex steroid hormone.
Caspase 6 activity in entorhinal cortex identifies aged individuals at risk for developing Alzheimer's disease.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
, caspase 6, apoptosis-related cysteine protease
, caspase 6
, apoptotic protease Mch-2
, apoptotic protease MCH-2