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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||12 Antibodies||32 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||3 Antibodies|
|Immunochromatography (IC)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies||5 Antibodies|
|Immunofluorescence (IF)||3 Antibodies||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||12 Antibodies||12 Antibodies|
|Immunohistochemistry (IHC)||30 Antibodies||43 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||45 Antibodies|
|Immunoprecipitation (IP)||10 Antibodies|
|Simple Western (SimWes)||1 Antibodies|
|Western Blotting (WB)||73 Antibodies|
|Antigen||Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Caspase 7 antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|10 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 7 AntibodyTarget Details Caspase 7 Application Details Handling References for anti-Caspase 7 Antibody (ABIN222955) Images
The antibody detects only the large subunit of cleaved caspase-7.
The antibody does not recognize full length of caspase-7 or other caspases.
|Immunogen||Synthetic peptide surrounding amino acid 195 of human caspase-7|
Target Details Caspase 7Product Details anti-Caspase 7 Antibody Application Details Handling References for anti-Caspase 7 Antibody (ABIN222955) Images back to top
|Alternative Name||Caspase-7 (CASP7 Antibody Abstract)|
Caspase-7 has been identified as a major contributor to the execution of apoptosis. Caspase-7 is cleaved by many enzymes, including caspase-3, -6, -8, -9 and granzyme B. Active caspase-7 consists of a heterotetramer of two large and two small subunits. As an effector caspase, caspase-7 cleaves many of the same substrates as caspase-3, including poly (ADP-ribose) polymerase (PARP). The active caspase-7 antibody provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells.
Synonyms: CASP7,CASP-7,ICE-LAP3,CMH-1,MCH3, EC 22.214.171.124
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Caspase 7 Antibody Target Details Caspase 7 Handling References for anti-Caspase 7 Antibody (ABIN222955) Images back to top
Western blotting (0.5-4 μg/mL), Immunoprecipitation (10-20 μg/mL), and Immunohistochemistry (10-20 μg/mL).
However, the optimal concentrations should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 7 Antibody Target Details Caspase 7 Application Details References for anti-Caspase 7 Antibody (ABIN222955) Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit anti-Active caspase-7 antibody in phosphate-buffered saline (PBS) containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-Caspase 7 Antibody (ABIN222955)Product Details anti-Caspase 7 Antibody Target Details Caspase 7 Application Details Handling Images back to top
|Product cited in:||
Schwartz, Barker, Kaufman, Fayram, McCracken, Allen: "Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 7, pp. 3351-63, 2012
Luyer, Derikx, Beyaert, Hadfoune, van Kuppevelt, Dejong, Heineman, Buurman, Greve: "High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock." in: Journal of hepatology, Vol. 50, Issue 2, pp. 342-50, 2009
Singh, Bond, Powell, Singh, Bumpers, Grizzle, Lillard: "CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth." in: Molecular cancer therapeutics, Vol. 8, Issue 1, pp. 178-84, 2009
Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, 2009
Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: "Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death." in: The Journal of biological chemistry, Vol. 283, Issue 50, pp. 34954-65, 2008
Huang, Masselli, Frisch, Hunton, Jiang, Wang: "Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb." in: The Journal of biological chemistry, Vol. 282, Issue 40, pp. 29401-13, 2007
Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: "WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 98, Issue 2, pp. 366-74, 2007
Scarabelli, Pasini, Ferrari, Ferrari, Stephanou, Lawrence, Townsend, Chen-Scarabelli, Gitti, Saravolatz, Latchman, Knight, Gardin: "Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells." in: The Journal of thoracic and cardiovascular surgery, Vol. 128, Issue 3, pp. 364-71, 2004
de Vries, Matthijsen, van Bijnen, Wolfs, Buurman: "Lysophosphatidic acid prevents renal ischemia-reperfusion injury by inhibition of apoptosis and complement activation." in: The American journal of pathology, Vol. 163, Issue 1, pp. 47-56, 2003
Scarabelli, Stephanou, Pasini, Comini, Raddino, Knight, Latchman: "Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury." in: Circulation research, Vol. 90, Issue 6, pp. 745-8, 2002
ImagesProduct Details anti-Caspase 7 Antibody Target Details Caspase 7 Application Details Handling References for anti-Caspase 7 Antibody (ABIN222955) back to top