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Browse our anti-Caspase 8 (CASP8) Antibodies

Full name:
anti-Caspase 8, Apoptosis-Related Cysteine Peptidase Antibodies (CASP8)
On www.antibodies-online.com are 391 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antibodies from 36 different suppliers available. Additionally we are shipping Caspase 8 Kits (58) and Caspase 8 Proteins (24) and many more products for this protein. A total of 493 Caspase 8 products are currently listed.
Synonyms:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
list all antibodies Gene Name GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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Most Popular Reactivities for anti-Caspase 8 (CASP8) Antibodies

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Top referenced anti-Caspase 8 Antibodies

  1. Human Polyclonal Caspase 8 Primary Antibody for IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Show all 9 references for ABIN724205

  2. Cow (Bovine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN222878 : Peluffo, Stouffer, Tesone: Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)
    Show all 5 references for ABIN222878

  3. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Show all 4 references for ABIN223020

  4. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
    Show all 3 references for ABIN1532005

  5. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
    Show all 3 references for ABIN1536108

  6. Human Polyclonal Caspase 8 Primary Antibody for FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Show all 2 references for ABIN390474

  7. Human Polyclonal Caspase 8 Primary Antibody for IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN222959

  8. Human Polyclonal Caspase 8 Primary Antibody for WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Show all 2 references for ABIN783312

  9. Human Polyclonal Caspase 8 Primary Antibody for IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Show all 2 references for ABIN1105679

More Antibodies against Caspase 8 Interaction Partners

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (show AMD1 Antibodies)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (show TP53 Antibodies)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Antibodies) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. studies have uncovered the combined actions of the NLRP3 (show NLRP3 Antibodies) inflammasome and caspase 8 leading to IL-1beta (show IL1B Antibodies) maturation and the directionality of IL-1beta (show IL1B Antibodies) in driving disease inPstpip2(cmo (show PSTPIP2 Antibodies))mice.

  2. Chronic TLR Stimulation Controls NLRP3 (show NLRP3 Antibodies) Inflammasome Activation through IL-10 (show IL10 Antibodies) Mediated Regulation of NLRP3 (show NLRP3 Antibodies) Expression and Caspase-8 Activation

  3. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  4. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (show RIPK3 Antibodies)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (show LYZ Antibodies) M) Casp8fl/fl (caspase 8) mice.

  5. CASP8 deletion did not affect the overall number of microglia expressing the pan (show SUPT6H Antibodies) specific microglia marker, Iba1 (show AIF1 Antibodies)

  6. We observed that NDMP generation was dependent on the extrinsic caspase (show CASP3 Antibodies) apoptotic pathway (caspase 3 (show CASP3 Antibodies) and caspase 8), cAMP activation of PKA but not of Epac (show RAPGEF3 Antibodies), and on activation of MLCK (show MYLK Antibodies).

  7. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 (show CASP1 Antibodies) and the Noncanonical Caspase-8 Inflammasomes.

  8. Casp8-dependent migration of enterocytes is likely involved in intestinal physiology and inflammation-related pathophysiology.

  9. NLRP3 (show NLRP3 Antibodies) inflammasomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta (show IL1B Antibodies)-converting protease

  10. The non-receptor tyrosine kinase (show TNK1 Antibodies) Tec (show NR4A3 Antibodies) controls assembly and activity of the noncanonical caspase-8 inflammasome.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Findings showed that, in MDA-MB-231 cells, casp-8 might play some unusual roles which should be better explored, in order to understand whether it might be identified as a molecular therapeutic target.

  2. Study showed that TRAIL and caspase-8 expression decreased in human osteosarcoma, resulting in increased cell proliferation, and reduced cell apoptosis suggesting they play important roles in the occurrence, development, and prognosis of osteosarcoma.

  3. evidence that Articulatin-D efficiently activates caspase-8 involved in extrinsic pathway of apoptosis induction, which ultimately results in caspase-3 (show CASP3 Antibodies)-dependent DNA fragmentation of Jurkat cells.

  4. Copper induces the activation of apoptosis through casp3 (show CASP3 Antibodies)/casp8/casp9 (show CASP9 Antibodies)/AIF (show AIFM1 Antibodies)/TP53 (show TP53 Antibodies) signaling pathways. Suggest that apoptosis activation mechanism is dependent on the concentration, time of exposure to Cu and cell type.

  5. our findings indicate that the expression levels of P-GP (show ABCB4 Antibodies), MYC (show MYC Antibodies), caspase-8, and AKT3 (show AKT3 Antibodies) are candidate biomarkers of cell sensitivity to PLKis.

  6. Overexpression of CASP8 is associated with lung cancer.

  7. Thymoquinone inhibitory effects were associated with inhibition of NF-kappaB (show NFKB1 Antibodies) and altered expression of its downstream effectors IL-8 (show IL8 Antibodies) and its receptors, the anti-apoptotic Bcl-2 (show BCL2 Antibodies), Bcl-xL (show BCL2L1 Antibodies), X-IAP (show ALPI Antibodies), and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9 (show CASP9 Antibodies), Bcl-xS (show BCL2L1 Antibodies), and cytochrome c (show CYCS Antibodies).

  8. Direct non-homotypic interactions of HPV18 E2 transactivation domain (TAD (show CRTAM Antibodies)) with alpha2/alpha5 helices of procaspase-8 death effector domain-B (DED (show AATF Antibodies)-B) mediate cell death in HEK293 cells.

  9. CASP8 rs3769823 and IDH2 (show IDH2 Antibodies) rs4561444 were as the potential functional variants in high-linkage disequilibrium with these single nucleotide polymorphisms, respectively. The IDH2 (show IDH2 Antibodies) mRNA levels were down-regulated in oesophageal squamous cell carcinoma.

  10. The CASP8 rs700635[C] allele, which is associated with increased risk of cutaneous basal-cell carcinoma and breast cancer, is protective against prostate cancer.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (show CASP3 Antibodies) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (show CASP9 Antibodies).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (show STAT1 Antibodies) at Ser (show SIGLEC1 Antibodies)-727 and STAT1 (show STAT1 Antibodies) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-12p40, IL-1beta (show IL1B Antibodies), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (show BCL2L1 Antibodies).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Antibodies) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (show CASP2 Antibodies) and P53 (show TP53 Antibodies)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Antibodies).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Antigen Profile

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) antibody
  • death related ced-3/Nedd2-like protein (Dredd) antibody
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) antibody
  • caspase-8 (AaeL_AAEL014148) antibody
  • caspase-8 (casp8) antibody
  • caspase 8 (LOC100222284) antibody
  • caspase 8 (Casp8) antibody
  • caspase 8 (LOC100348477) antibody
  • ALPS2B antibody
  • CAP4 antibody
  • Casp-8 antibody
  • CASP8 antibody
  • casp8-A antibody
  • caspase-8 antibody
  • FLICE antibody
  • MACH antibody
  • MCH5 antibody
  • xCaspase-8 antibody
  • zgc:92075 antibody

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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