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Browse our anti-Caspase 8 (CASP8) Antibodies

Full name:
anti-Caspase 8, Apoptosis-Related Cysteine Peptidase Antibodies (CASP8)
On www.antibodies-online.com are 387 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antibodies from 36 different suppliers available. Additionally we are shipping Caspase 8 Kits (67) and Caspase 8 Proteins (27) and many more products for this protein. A total of 503 Caspase 8 products are currently listed.
Synonyms:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
list all antibodies Gene Name GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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Most Popular Reactivities for anti-Caspase 8 (CASP8) Antibodies

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anti-Mouse (Murine) Caspase 8 Antibodies:

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anti-Human Caspase 8 Antibodies:

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Top referenced anti-Caspase 8 Antibodies

  1. Human Polyclonal Caspase 8 Primary Antibody for IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Show all 10 references for ABIN724205

  2. Cow (Bovine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN222878 : Peluffo, Stouffer, Tesone: Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)
    Show all 5 references for ABIN222878

  3. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Show all 4 references for ABIN223020

  4. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
    Show all 3 references for ABIN1536108

  5. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
    Show all 3 references for ABIN1532005

  6. Human Polyclonal Caspase 8 Primary Antibody for IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Show all 2 references for ABIN1105679

  7. Human Polyclonal Caspase 8 Primary Antibody for FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Show all 2 references for ABIN390474

  8. Human Polyclonal Caspase 8 Primary Antibody for IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN222959

  9. Human Polyclonal Caspase 8 Primary Antibody for WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Show all 2 references for ABIN783312

More Antibodies against Caspase 8 Interaction Partners

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (show AMD1 Antibodies)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (show TP53 Antibodies)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Antibodies) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Statistically significant increases in the expression of Fas (show FAS Antibodies) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (show DAPK1 Antibodies), Traf3 (show TRAF3 Antibodies), Tnsf12, Tnfrsf1A (show TNFRSF1A Antibodies) and Ripk1 (show RIPK1 Antibodies).

  2. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (show RIPK3 Antibodies))-mediated necroptosis.

  3. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

  4. Data indicate that NLRC4 (show NLRC4 Antibodies) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Antibodies) release, and implicate Caspase-8 in NLRC4 (show NLRC4 Antibodies) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Antibodies) and Caspase-8.

  5. ING4 (show ING4 Antibodies) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (show FAS Antibodies)-induced apoptosis in a caspase-8-dependent pathway.

  6. studies have uncovered the combined actions of the NLRP3 (show NLRP3 Antibodies) inflammasome and caspase 8 leading to IL-1beta (show IL1B Antibodies) maturation and the directionality of IL-1beta (show IL1B Antibodies) in driving disease inPstpip2(cmo (show PSTPIP2 Antibodies))mice.

  7. Chronic TLR Stimulation Controls NLRP3 (show NLRP3 Antibodies) Inflammasome Activation through IL-10 (show IL10 Antibodies) Mediated Regulation of NLRP3 (show NLRP3 Antibodies) Expression and Caspase-8 Activation

  8. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  9. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (show RIPK3 Antibodies)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (show LYZ Antibodies) M) Casp8fl/fl (caspase 8) mice.

  10. CASP8 deletion did not affect the overall number of microglia expressing the pan (show SUPT6H Antibodies) specific microglia marker, Iba1 (show AIF1 Antibodies)

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Dysregulation of a potassium channel (show KCNAB2 Antibodies), THIK-1 (show KCNK13 Antibodies), targeted by caspase-8, accelerates cell shrinkage.

  2. caspase-8 and caspase-9 (show CASP9 Antibodies) contribute to the cyclic stretch-induced apoptosis, but functioned differently at different stages in human periodontal ligament cells

  3. Down-regulation of mRNA expression was found in cases in which CASP8, TMS1 (show SERINC3 Antibodies) and DAPK (show DAPK1 Antibodies) were hypermethylated.

  4. High levels of FADD (show FADD Antibodies) and caspase-8, but not caspase-3 (show CASP3 Antibodies), were associated with increased incidence of coronary events in subjects from the general population.

  5. sorafenib overcomes TRAIL resistance in renal cell carcinoma (show MOK Antibodies) by a mechanism that does not rely on Mcl-1 (show MCL1 Antibodies) down-regulation but involves ROS (show ROS1 Antibodies) accumulation and increased activation of caspase-8

  6. autoinflammation-associated H443P nlrc4 (show NLRC4 Antibodies) mutant is altered in interaction with SUG1 (show PSMC5 Antibodies) and ubiquitinated proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD (show FADD Antibodies) but independent of Ser (show SIGLEC1 Antibodies)(533) phosphorylation.

  7. Caspase-8 is phosphorylated on Tyr380 in a Src kinase (show CSK Antibodies) dependent manner and this phosphorylation is required for transformation and it is enhanced by hypoxic conditions.

  8. Our results revealed that caspase-8 gene silencing may result from the methylation of its gene promoter in human glioma tissues. The expression of caspase-8 at the mRNA level was significantly associated with the grade of human glioma.

  9. Suggest that caspase 8 SNPs were not associated with rheumatoid arthritis.

  10. novel dynamic interplay between Src (show SRC Antibodies) and caspase-8 likely acts as a potent signal-integrating switch directing the cell towards apoptosis or survival

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (show CASP3 Antibodies) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (show CASP9 Antibodies).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (show STAT1 Antibodies) at Ser (show SIGLEC1 Antibodies)-727 and STAT1 (show STAT1 Antibodies) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-12p40, IL-1beta (show IL1B Antibodies), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (show BCL2L1 Antibodies).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Antibodies) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (show CASP2 Antibodies) and P53 (show TP53 Antibodies)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Antibodies).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Antigen Profile

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) antibody
  • death related ced-3/Nedd2-like protein (Dredd) antibody
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) antibody
  • caspase-8 (AaeL_AAEL014148) antibody
  • caspase-8 (casp8) antibody
  • caspase 8 (LOC100222284) antibody
  • caspase 8 (Casp8) antibody
  • caspase 8 (LOC100348477) antibody
  • ALPS2B antibody
  • CAP4 antibody
  • Casp-8 antibody
  • CASP8 antibody
  • casp8-A antibody
  • caspase-8 antibody
  • FLICE antibody
  • MACH antibody
  • MCH5 antibody
  • xCaspase-8 antibody
  • zgc:92075 antibody

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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