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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||133 Antibodies||14 Antibodies||13 Antibodies|
|Immunoprecipitation (IP)||9 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies||2 Antibodies||2 Antibodies|
|Immunohistochemistry (IHC)||28 Antibodies||8 Antibodies||9 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies||1 Antibodies||1 Antibodies|
|Immunofluorescence (IF)||12 Antibodies|
|Immunocytochemistry (ICC)||18 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Antigen||CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CRADD antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-CRADD AntibodyTarget Details CRADD Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412895|
|Specificity||The antibody detects a 22 kDa band, corresponding to the expected molecular mass of RAIDD on immunoblots.|
|Immunogen||Synthetic peptide surrounding amino acid 171 of human RAIDD|
Target Details CRADDProduct Details anti-CRADD Antibody Application Details Handling Images back to top
|Alternative Name||RAIDD (CRADD Antibody Abstract)|
Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. The complex processes procaspase-9 into a large subunit (35 kDa or 17-25 kDa) and small (10 kDa) by self-cleavage at D315. Activated caspase-9 further cleaves other caspase members including caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. In addition to self-cleavage, procaspase-9 can also be cleaved in vivo by caspase-3 at D330. The process served as a positive feedback to amplify the apoptotic signal in caspase activation pathway.
Synonyms: CRADD, MGC9163,
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-CRADD Antibody Target Details CRADD Handling Images back to top
Western blot analysis (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-CRADD Antibody Target Details CRADD Application Details Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit anti-RAIDD polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-CRADD Antibody Target Details CRADD Application Details Handling back to top