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Browse our CRADD Proteins (CRADD)

Full name:
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain Proteins (CRADD)
On www.antibodies-online.com are 17 CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) Proteins from 11 different suppliers available. Additionally we are shipping CRADD Antibodies (130) and CRADD Kits (2) and many more products for this protein. A total of 158 CRADD products are currently listed.
Synonyms:
CRADD, DKFZp468A2219, LOC100226369, MGC78788, MGC89035, MRT34, RAIDD, zgc:101717
list all proteins Gene Name GeneID UniProt
CRADD 8738 P78560
Rat CRADD CRADD 314756  
CRADD 12905 O88843

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CRADD Proteins (CRADD) by Origin

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Top referenced CRADD Proteins

  1. Human CRADD Protein expressed in Escherichia coli (E. coli) - ABIN667087 : Park, Wu: Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. in Journal of molecular biology 2006 (PubMed)
    Show all 2 references for ABIN667087

  2. Human CRADD Protein expressed in Escherichia coli (E. coli) - ABIN2005351 : Chou, Matsuo, Duan, Wagner: Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. in Cell 1998 (PubMed)
    Show all 2 references for ABIN2005351

More Proteins for CRADD Interaction Partners

Human CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) interaction partners

  1. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists

  2. Study identified sequence variants in the known disease-causing genes SLC6A3 (show SLC6A3 Proteins) and FLVCR1 (show FLVCR1 Proteins), and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1 (show C7orf27 Proteins), SNIP1 (show SNIP1 Proteins), CRADD, and HARS (show HARS Proteins).

  3. point mutations on RAIDD (R147E) and on PIDD (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed

  4. The expressions of PIDD and RAIDD are upregulated during tumour progression in renal cell carcinomas.

  5. As a first step towards elucidating the molecular mechanisms of caspase-2 (show CASP2 Proteins) activation, data report the crystal structure of the RAIDD death domain at 2.0 A resolution.

  6. PIDD death domain (DD) and RAIDD DD assemble into an oligomeric complex. Within the PIDDosome, the interaction between PIDD and RAIDD is mediated by a homotypic interaction between their death domains.

  7. impaired expression of RAIDD in drug induced apoptosis may play a role in the multidrug resistance of osteosarcoma cells

Mouse (Murine) CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) interaction partners

  1. The tumor-modulatory effects of Caspase-2 (show CASP2 Proteins) and Pidd1 do not require the scaffold protein (show HOMER1 Proteins) Raidd

  2. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists

  3. Neuronal caspase-2-dependent execution of neurons requires recptor-interacting protein RAIDD, not p53-inducible protein with a death domain (PIDD).

  4. We show that CRADD interacts with BCL10 (show BCL10 Proteins) through its caspase (show CASP3 Proteins) recruitment domain and suppresses interactions between BCL10 (show BCL10 Proteins) and CARMA1 (show CARD11 Proteins)

  5. Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes.

  6. P53-induced protein with a death domain -induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor-interacting protein (RIP (show RIPK1 Proteins))-associated ICH-1 (show CASP2 Proteins)/CED-3 homologous protein with a death domain (RAIDD).

CRADD Protein Profile

Protein Summary

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

Alternative names and synonyms associated with CRADD

  • CASP2 and RIPK1 domain containing adaptor with death domain (CRADD)
  • CASP2 and RIPK1 domain containing adaptor with death domain (cradd)
  • CASP2 and RIPK1 domain containing adaptor with death domain (LOC100226369)
  • CASP2 and RIPK1 domain containing adaptor with death domain (LOC100354517)
  • CASP2 and RIPK1 domain containing adaptor with death, gene 2 (cradd.2)
  • CASP2 and RIPK1 domain containing adaptor with death domain (Cradd)
  • CRADD protein
  • DKFZp468A2219 protein
  • LOC100226369 protein
  • MGC78788 protein
  • MGC89035 protein
  • MRT34 protein
  • RAIDD protein
  • zgc:101717 protein

Protein level used designations for CRADD

death domain-containing protein CRADD , CASP2 and RIPK1 domain containing adaptor with death domain , Death domain-containing protein CRADD , death domain-containing protein cradd , CASP2 and RIPK1 domain containing adaptor with death, gene 2 , RIP-associated ICH1/CED3-homologous protein with death domain , RIP-associated protein with a death domain , caspase and RIP adaptor with death domain , death adaptor molecule RAIDD , CASP2 and RIPK1 domain-containing adaptor with death domain , caspase and RIP adapter with death domain

GENE ID SPECIES
417900 Gallus gallus
448758 Xenopus (Silurana) tropicalis
450046 Danio rerio
452128 Pan troglodytes
482604 Canis lupus familiaris
615788 Bos taurus
711165 Macaca mulatta
100173528 Pongo abelii
100226369 Taeniopygia guttata
100354517 Oryctolagus cuniculus
100529043 Ictalurus punctatus
443742 Xenopus laevis
8738 Homo sapiens
314756 Rattus norvegicus
12905 Mus musculus
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