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anti-Rat (Rattus) CYLD Antibodies:
anti-Mouse (Murine) CYLD Antibodies:
anti-Human CYLD Antibodies:
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Mouse (Murine) Polyclonal CYLD Primary Antibody for WB - ABIN374832
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. in Cell 2006
Human Polyclonal CYLD Primary Antibody for ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. in Infection and immunity 2010
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 Antibodies)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 Antibodies)-linked chains are presented.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 Antibodies)-mediated signaling by directly interacting with MyD88 (show MYD88 Antibodies) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 Antibodies) at lysine 231.
CYLD interrupts the ERK (show EPHB2 Antibodies)- and p38 (show CRK Antibodies)-/AP-1 (show JUN Antibodies) and c-Myc (show MYC Antibodies) pathways to suppress Nrf2 (show NFE2L2 Antibodies)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Data show that the in utero death of NF-NF (show NFASC Antibodies)-kappaB (show NFKB1 Antibodies) essential modulator (NEMO (show IKBKG Antibodies)) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Antibodies) receptor 1 (TNFR1 (show TNFRSF1A Antibodies)) signaling and can be rescued by TNFR1 (show TNFRSF1A Antibodies) deficiency.
CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (show NFKB1 Antibodies) dependent anti-apoptotic signaling.
In contrast to full-length CYLD, the immune function of short splice variant CYLD (sCYLD) is insufficiently described. To explore sCYLD's function in infection, investigated whether dendritic cell-specific sCYLD regulates the pathogenesis of listeriosis.
The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin (show UBB Antibodies) chain from centrosomal protein of 70 kDa (Cep70 (show CEP70 Antibodies)), a requirement for Cep70 (show CEP70 Antibodies) to interact with gamma-tubulin (show TUBG1 Antibodies) and localize at the centrosome.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (show STAT3 Antibodies) and miR (show MLXIP Antibodies)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
CYLD Promotes TNF-alpha (show TNF Antibodies)-Induced Cell Necrosis Mediated by RIP-1 (show UQCRFS1 Antibodies) in Human Lung Cancer Cells
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (show NFKB1 Antibodies) pathway and the downstream targets, livin (show BIRC7 Antibodies) and survivin (show BIRC5 Antibodies), which potentially induced GC chemoresistance.
Data show that cylindromatosis (CYLD) overexpression and livin (show BIRC7 Antibodies) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (show BLNK Antibodies)) cells.
aberrantly expressed miR (show MLXIP Antibodies)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer
These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.
Novel CYLD germline mutations c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8 were identified in unrelated Brooke-Spiegler Syndrome patients.
Study founds the levels of CYLD and SMAD7 (show SMAD7 Antibodies) significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD suppresses OSCC metastases through SMAD7 (show SMAD7 Antibodies). Downregulation of CYLD appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, ubiquitin carboxyl-terminal hydrolase CYLD
, deubiquitinating enzyme CYLD
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, retinitis pigmentosa 1 homolog
, ubiquitin specific peptidase like 2