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anti-Human Cytochrome C antibody for Neutralization

Recommended Cytochrome C Antibody (supplied by: Log in to see )

Antigen
Cytochrome C, Somatic (CYCS) Antibodies
  • bln
  • bs30f07.y1
  • CG13263
  • CG17903
  • CYC
  • cyc
  • CYCS
  • cycs
  • CYCSA
  • cyct
  • cyt-c-d
  • cyt-c-p
  • Cyt-c1
  • cyt-c2
  • Cyt-c2
  • cyt.c
  • Cyt C
  • Cyt c
  • cyt c
  • Cytc
  • cytc
  • CytC-1
  • CytC-2
  • Cytc-d
  • cyt c-d
  • Cytc-p
  • cyt c-p
  • CytC1
  • cytochrome c
  • DC3
  • dc3
  • dc4
  • DC4
  • DMc01
  • Dmel\\CG13263
  • Dmel\\CG17903
  • ENSMUSG00000058927
  • hcs
  • HCS
  • ms(2)04445
  • pDMc01
  • pDMc02
  • THC4
  • wu:fk52b01
  • zgc:86706
Reactivity
Human, Mouse (Murine), Rat (Rattus)
306
229
172
94
62
56
28
28
28
25
24
19
16
8
7
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
Host
Mouse
236
138
7
2
Clonality
Monoclonal
Conjugate
This Cytochrome C antibody is un-conjugated
20
14
10
7
7
6
6
5
5
5
5
5
5
5
5
5
5
5
2
1
1
1
1
1
1
1
1
Application
Neutralization (Neut)
278
157
138
81
69
67
48
34
19
11
11
7
6
6
5
4
4
4
3
3
2
1
1
1
1
1
1
1
1
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Catalog No. ABIN2666071
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008735937 ABIN2666072 Neut Mouse IgG1 kappa Log in to see 6H2-B4 10
0.0008735937 ABIN4301950 BP IHC (fro) IP Neut Mouse IgG1 kappa Log in to see 6H2-B4
0.0008735937 ABIN4301951 BP IHC (fro) IP Neut Mouse IgG1 kappa Log in to see 6H2-B4
0.0008735937 ABIN4301966 BP IHC (fro) IP Neut WB DyLight 650 Mouse IgG1 kappa Log in to see 6H2-B4
0.0008735937 ABIN4301968 BP IHC (fro) IP Neut WB DyLight 550 Mouse IgG1 kappa Log in to see 6H2-B4
0.0008735937 ABIN4301967 BP IHC (fro) IP Neut WB HRP Mouse IgG1 kappa Log in to see 6H2-B4

Top referenced anti-Cytochrome C antibody for Neutralization

Similar anti-Cytochrome C Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Western Blotting (WB) 220 Antibodies 117 Antibodies 169 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Neutralization (Neut) 8 Antibodies 7 Antibodies 7 Antibodies
Intracellular Staining (ICS) 4 Antibodies 2 Antibodies 2 Antibodies
Immunostaining (ISt) 1 Antibodies
Immunoprecipitation (IP) 30 Antibodies 16 Antibodies 23 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 129 Antibodies 69 Antibodies 120 Antibodies
Immunohistochemistry (IHC) 72 Antibodies 48 Antibodies 49 Antibodies

General

Antigen Cytochrome C, Somatic (CYCS) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(306), (229), (172), (94), (62), (56), (28), (28), (28), (25), (24), (19), (16), (8), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(236), (138), (7), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Cytochrome C antibody is un-conjugated
(20), (14), (10), (7), (7), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Neutralization (Neut)
(278), (157), (138), (81), (69), (67), (48), (34), (19), (11), (11), (7), (6), (6), (5), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 10 references available
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Product Details anti-Cytochrome C Antibody

Target Details Cytochrome C Application Details Handling References for anti-Cytochrome C Antibody (ABIN2666071) Images
Purification The antibody was purified by affinity chromatography.
Clone 6H2-B4
Isotype IgG1 kappa

Target Details Cytochrome C

Product Details anti-Cytochrome C Antibody Application Details Handling References for anti-Cytochrome C Antibody (ABIN2666071) Images back to top
Antigen
Alternative Name Cytochrome C (CYCS Antibody Abstract)
Background Cytochrome c is a 15 kD protein found in the mitochondrial intermembrane space with a heme-binding domain. Cytochrome c is a component of the electron transport chain, the heme group transfers electrons from cytochrome b-c1 complex to cytochrome oxidase complex. Cytochrome c initiates apoptosis by release to cytoplasm and binding Apaf-1 which activates procaspase 9. Cytochrome c interacts with the cytochrome b-c1 complex, cytochrome oxidase complex, heme, Apaf-1, and Caspase 9 proteins. The 6H2.B4 monoclonal antibody recognizes human, mouse, and rat cytochrome-c and has been shown to be useful for intracellular flow cytometric staining, Western blotting, immunoprecipitation, and immunofluorescence staining.
Research Area Cancer, Apoptosis/Necrosis, Metabolism
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Handling References for anti-Cytochrome C Antibody (ABIN2666071) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details References for anti-Cytochrome C Antibody (ABIN2666071) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store between 2°C and 8°C.

References for anti-Cytochrome C Antibody (ABIN2666071)

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling Images back to top
Background publications

McGuire, Barlan, Griffin, Wiethoff: "Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species." in: Journal of virology, Vol. 85, Issue 20, pp. 10806-13, 2011

She, Zhang, Marchionini, Diaz, Jetton, Kimball, Vary, Lang, Lynch: "Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 1, pp. E49-61, 2011

Ferguson, Marietta, Van Den Berg: "UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 45793-800, 2003

Zhang, Gerstein: "The human genome has 49 cytochrome c pseudogenes, including a relic of a primordial gene that still functions in mouse." in: Gene, Vol. 312, pp. 61-72, 2003

Semenkova, Dudich, Dudich, Tokhtamisheva, Tatulov, Okruzhnov, Garcia-Foncillas, Palop-Cubillo, Korpela: "Alpha-fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation." in: European journal of biochemistry / FEBS, Vol. 270, Issue 21, pp. 4388-99, 2003

Chandra, Liu, Tang: "Early mitochondrial activation and cytochrome c up-regulation during apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 52, pp. 50842-54, 2002

Shih, Wu, Hung, Yang, Lin: "Abrin triggers cell death by inactivating a thiol-specific antioxidant protein." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21870-7, 2001

Liu, Kim, Yang, Jemmerson, Wang: "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." in: Cell, Vol. 86, Issue 1, pp. 147-57, 1996

Goshorn, Retzel, Jemmerson: "Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c." in: The Journal of biological chemistry, Vol. 266, Issue 4, pp. 2134-42, 1991

Jemmerson, Johnson, Burrell, Taylor, Jenkins: "A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells." in: European journal of immunology, Vol. 21, Issue 1, pp. 143-51, 1991

Images

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling References for anti-Cytochrome C Antibody (ABIN2666071) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Cytochrome C antibody (Cytochrome C, Somatic) (ABIN2666071) anti-Cytochrome C, Somatic (CYCS) antibody
Western Blotting (WB) image for anti-Cytochrome C antibody (Cytochrome C, Somatic) (ABIN2666071) anti-Cytochrome C, Somatic (CYCS) antibody (Image 2)