Browse our anti-DFFA (DFFA) Antibodies

Full name:
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide Antibodies (DFFA)
On are 228 DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) Antibodies from 31 different suppliers available. Additionally we are shipping DFFA Proteins (17) and DFFA Kits (1) and many more products for this protein. A total of 266 DFFA products are currently listed.
A330085O09Rik, DFF-45, DFF1, DFF35, Dff45, DFFA, ICAD, ICAD-L, ICAD-S
list all antibodies Gene Name GeneID UniProt
DFFA 1676 O00273
DFFA 13347 O54786
DFFA 114214  

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Most Popular Reactivities for anti-DFFA (DFFA) Antibodies

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anti-Human DFFA Antibodies:

anti-Mouse (Murine) DFFA Antibodies:

anti-Rat (Rattus) DFFA Antibodies:

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Top referenced anti-DFFA Antibodies

  1. Human Monoclonal DFFA Primary Antibody for IF, WB - ABIN968331 : Fulda, Meyer, Debatin: Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. in Oncogene 2002 (PubMed)
    Show all 5 references for 968331

  2. Mouse (Murine) Polyclonal DFFA Primary Antibody for WB - ABIN967295 : Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. in Nature 1998 (PubMed)
    Show all 4 references for 967295

  3. Human Polyclonal DFFA Primary Antibody for EIA, WB - ABIN951895 : Ninios, Sekeri-Pataryas, Sourlingas: Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. in Apoptosis : an international journal on programmed cell death 2010 (PubMed)
    Show all 3 references for 951895

  4. Cow (Bovine) Polyclonal DFFA Primary Antibody for WB - ABIN2779329 : Yan, Fu, Li, Blechl, Tranquilli, Bonafede, Sanchez, Valarik, Yasuda, Dubcovsky: The wheat and barley vernalization gene VRN3 is an orthologue of FT. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 references for 2779329

  5. Mouse (Murine) Polyclonal DFFA Primary Antibody for IHC (p), WB - ABIN121553 : Wyllie: Apoptosis. An endonuclease at last. in Nature 1998 (PubMed)
    Show all 2 references for 121553

  6. Human Polyclonal DFFA Primary Antibody for IHC, ELISA - ABIN1534436 : Liu, Zou, Slaughter, Wang: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. in Cell 1997 (PubMed)

  7. Human Polyclonal DFFA Primary Antibody for ELISA, ICC - ABIN4305087 : Nagata, Kishi, Liu, Matsuda, Imanaka, Tsukada, Kang, Muraguchi: The regulation of DNAse activities in subcellular compartments of activated thymocytes. in Immunology 2002 (PubMed)

More Antibodies against DFFA Interaction Partners

Human DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

  1. Data show that the caspase-activated DNase (CAD (show DFFB Antibodies)) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.

  2. Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.

  3. ICAD deficiency was associated with severe genomic instability.

  4. mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim (show BCL2L11 Antibodies), Bcl-x (show BCL2L1 Antibodies), and ICAD in Pnn (show PNN Antibodies)-depleted MCF-7 cells.

  5. The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.

  6. study reveals a previously unrecognized function of miR (show MLXIP Antibodies)-145 in DFF45 processing, which may underlie crucial aspects of cancer biology

  7. The heterodimer, DFF40 (show DFFB Antibodies)-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.

  8. DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma (show ARHGEF16 Antibodies) tumors

  9. NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity

  10. Hypoxia-induced cleavage of caspase-3 (show CASP3 Antibodies) and DFF45/ICAD in human failed cardiomyocytes.

Mouse (Murine) DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

  1. Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 (show DFFB Antibodies) and DFF45 reversed the apoptosis resistance normally observed in these cells

  2. a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory

  3. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression

DFFA Antigen Profile

Antigen Summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DFFA

  • DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA) antibody
  • DNA fragmentation factor, 45kDa, alpha polypeptide (dffa) antibody
  • DNA fragmentation factor, alpha subunit (Dffa) antibody
  • A330085O09Rik antibody
  • DFF-45 antibody
  • DFF1 antibody
  • DFF35 antibody
  • Dff45 antibody
  • DFFA antibody
  • ICAD antibody
  • ICAD-L antibody
  • ICAD-S antibody

Protein level used designations for DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide , DNA fragmentation factor subunit alpha , DFF45 , DNA fragmentation factor 45 kDa subunit , inhibitor of CAD , DFF-45

419451 Gallus gallus
457928 Pan troglodytes
487449 Canis lupus familiaris
507981 Bos taurus
548407 Xenopus (Silurana) tropicalis
713544 Macaca mulatta
100173283 Pongo abelii
1676 Homo sapiens
13347 Mus musculus
114214 Rattus norvegicus
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