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Browse our anti-DFFB (DFFB) Antibodies

Full name:
anti-DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) Antibodies (DFFB)
On www.antibodies-online.com are 136 DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) Antibodies from 21 different suppliers available. Additionally we are shipping DFFB Kits (26) and DFFB Proteins (8) and many more products for this protein. A total of 180 DFFB products are currently listed.
Synonyms:
40kDa, 5730477D02Rik, Cad, CPAN, DFF-40, DFF2, DFF40, Didff, LOC100223514

Most Popular Reactivities for anti-DFFB (DFFB) Antibodies

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anti-Human DFFB Antibodies:

anti-Rat (Rattus) DFFB Antibodies:

anti-Mouse (Murine) DFFB Antibodies:

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Top referenced anti-DFFB Antibodies

  1. Mouse (Murine) Polyclonal DFFB Primary Antibody for EIA, IHC (p) - ABIN499517 : Nagai, Dohmae, Nishimura, Kato, Hirata, Takahashi: Operando XAFS study of catalytic NO reduction over Cu/CeO2: the effect of copper-ceria interaction under periodic operation. in Physical chemistry chemical physics : PCCP 2013 (PubMed)
    Show all 5 references for ABIN499517

  2. Human Polyclonal DFFB Primary Antibody for EIA, IF - ABIN499736 : Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. in Nature 1998 (PubMed)
    Show all 5 references for ABIN499736

  3. Mouse (Murine) Polyclonal DFFB Primary Antibody for EIA, IHC (p) - ABIN499515 : Sakahira, Enari, Nagata: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. in Nature 1998 (PubMed)
    Show all 5 references for ABIN499515

  4. Human Polyclonal DFFB Primary Antibody for EIA, IF - ABIN499740 : Halenbeck, MacDonald, Roulston, Chen, Conroy, Williams: CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. in Current biology : CB 1998 (PubMed)
    Show all 5 references for ABIN499740

  5. Human Polyclonal DFFB Primary Antibody for EIA, IF - ABIN499738 : Liu, Li, Widlak, Zou, Luo, Garrard, Wang: The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 5 references for ABIN499738

  6. Human Polyclonal DFFB Primary Antibody for WB - ABIN967293 : Liu, Zou, Widlak, Garrard, Wang: Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1. in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 references for ABIN967293

  7. Human Polyclonal DFFB Primary Antibody for FACS, IHC (p) - ABIN951896 : Hanus, Kalinowska-Herok, Widlak: The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme. in Apoptosis : an international journal on programmed cell death 2008 (PubMed)
    Show all 4 references for ABIN951896

  8. Human Polyclonal DFFB Primary Antibody for FACS, IHC (p) - ABIN653798 : Hristoskova, Holzgreve, Hahn, Rusterholz: The chromatin of differentiating erythroblasts is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor. in Journal of cellular physiology 2007 (PubMed)

  9. Human Polyclonal DFFB Primary Antibody for WB - ABIN2784747 : Neimanis, Albig, Doenecke, Kahle: Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against DFFB Interaction Partners

Human DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) interaction partners

  1. Data suggest DFF40 expression in breast cancer cell line is involved in drug sensitivity/resistance to doxorubicin; apoptotic cell death due to doxorubicin (a topoisomerase II (show TOP2 Antibodies) inhibitor) is enhanced by DFF40 overexpression in breast cancer cell line.

  2. Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD (show DFFA Antibodies), resulting in the characteristic DNA laddering of apoptosis.

  3. Combinatorial use of some sulfonamides such as acetazolamide along with increased expression of DFF40 can potently kill tumor cells via apoptosis.

  4. DFF40/CAD-independent mechanism driving conformational nuclear changes during caspase (show CASP3 Antibodies)-dependent cell death

  5. the highest order of chromatin compaction observed in the later steps of caspase (show CASP3 Antibodies)-dependent apoptosis relies on DFF40/CAD-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks

  6. These results suggest a cooperative activity between CAD (show CAD Antibodies) and DNAS1L3 (show DNASE1L3 Antibodies) to accomplish internucleosomal DNA fragmentation .

  7. Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor (show DFFA Antibodies) 40

  8. During apoptotic rearrangement of interchromatin granule clusters, the nuclear matrix (NuMa (show NUMA1 Antibodies) rearrangement) and chromatin are closely associated. This process occurs in defined stages and depends on the activity of protein phosphatases, caspases and CAD (show CAD Antibodies).

  9. the cytosolic levels of DFF40/CAD are determinants in achieving a complete apoptotic phenotype, including oligonucleosomal DNA degradation.

  10. Data show that among the 13 SNPs in the 3 genes, only 3 were found to be polymorphic: R196K and K277R in the DFFB gene, and S12L in the EndoG (show ENDOG Antibodies) gene, and all 6 SNPs in the FEN-1 (show FEN1 Antibodies) gene were entirely monoallelic.

Mouse (Murine) DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) interaction partners

  1. the highest order of chromatin compaction observed in the later steps of caspase (show CASP3 Antibodies)-dependent apoptosis relies on DFF40/CAD-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks

  2. results show that caspase 3 (show CASP3 Antibodies)/CAD (show CAD Antibodies) promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes

  3. Co-transfection of mouse DFF45 (show DFFA Antibodies)(-/-) fibroblasts with plasmids encoding human DFF40 and DFF45 (show DFFA Antibodies) reversed the apoptosis resistance normally observed in these cells

  4. The thymus of DNase II(-/-)CAD (show CAD Antibodies)(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development.

  5. Interactions identified here between mouse liver histone H1 (show H1F0 Antibodies) carboxyl-terminal domain and DFF40/CAD target and activate linker DNA cleavage during the terminal stages of apoptosis.

  6. The results suggest that CAD protein (show CAD Antibodies) may be preferentially degraded by the ubiquitin-proteasome system in the absence of its inhibitor (ICAD (show DFFA Antibodies)) to maintain protein quality control.

  7. A los of caspase-activated DNASE enhances tumorigenesis induced by a chemical carcinogen in a model of skin carcinogenesis in mice.

DFFB Antigen Profile

Antigen Summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined.

Alternative names and synonyms associated with DFFB

  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB) antibody
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (LOC100223514) antibody
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (Dffb) antibody
  • DNA fragmentation factor, beta subunit (Dffb) antibody
  • 40kDa antibody
  • 5730477D02Rik antibody
  • Cad antibody
  • CPAN antibody
  • DFF-40 antibody
  • DFF2 antibody
  • DFF40 antibody
  • Didff antibody
  • LOC100223514 antibody

Protein level used designations for DFFB

DNA fragmentation factor subunit beta , DNA fragmentation factor, 40 kD, beta polypeptide , DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor 40 kDa subunit , caspase-activated DNase , caspase-activated deoxyribonuclease , caspase-activated nuclease , DFF-40 , DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, beta subunit , DNA fragmentation factor, 40 kD, beta subunit , DNase inhibited by DNA fragmentation factor

GENE ID SPECIES
374158 Gallus gallus
744932 Pan troglodytes
100223514 Taeniopygia guttata
1677 Homo sapiens
84359 Rattus norvegicus
100713108 Cavia porcellus
512730 Bos taurus
489623 Canis lupus familiaris
13368 Mus musculus
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