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|Antigen||DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This DFFB antibody is conjugated to Cy3 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-DFFB AntibodyTarget Details DFFB Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human DFFB|
Target Details DFFBProduct Details anti-DFFB Antibody Application Details Handling Images back to top
|Alternative Name||Dffb (DFFB Antibody Abstract)|
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
Synonyms: CAD, Caldesmon, Caspase activated deoxyribonuclease, Caspase activated DNase, Caspase activated nuclease, CDM, CPAN, Deoxyribonuclease III, caspase activated, DFF 40, DFF2, DFF40, Didff, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor subunit beta, DNA fragmentation factor, 40 Da, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kD beta subunit, DNA fragmentation factor, 40 kD, beta polypeptide, DNA fragmentation factor, 40 kDa, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kDa, beta polypeptide caspase-activated DNase, DNAation factor, beta subunit, DFFB_HUMAN.
|Research Area||Chromatin and Nuclear Signaling, Cell Cycle, Apoptosis/Necrosis|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-DFFB Antibody Target Details DFFB Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-DFFB Antibody Target Details DFFB Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|