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Browse our DFFB (DFFB) ELISA Kits

Full name:
DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) ELISA Kits (DFFB)
On www.antibodies-online.com are 26 DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) ELISA Kits from 5 different suppliers available. Additionally we are shipping DFFB Antibodies (136) and DFFB Proteins (8) and many more products for this protein. A total of 180 DFFB products are currently listed.
Synonyms:
40kDa, 5730477D02Rik, Cad, CPAN, DFF-40, DFF2, DFF40, Didff, LOC100223514

More ELISA Kits for DFFB Interaction Partners

Human DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) interaction partners

  1. Data suggest DFF40 expression in breast cancer cell line is involved in drug sensitivity/resistance to doxorubicin; apoptotic cell death due to doxorubicin (a topoisomerase II (show TOP2 ELISA Kits) inhibitor) is enhanced by DFF40 overexpression in breast cancer cell line.

  2. Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD (show DFFA ELISA Kits), resulting in the characteristic DNA laddering of apoptosis.

  3. Combinatorial use of some sulfonamides such as acetazolamide along with increased expression of DFF40 can potently kill tumor cells via apoptosis.

  4. DFF40/CAD-independent mechanism driving conformational nuclear changes during caspase (show CASP3 ELISA Kits)-dependent cell death

  5. the highest order of chromatin compaction observed in the later steps of caspase (show CASP3 ELISA Kits)-dependent apoptosis relies on DFF40/CAD-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks

  6. These results suggest a cooperative activity between CAD (show CAD ELISA Kits) and DNAS1L3 (show DNASE1L3 ELISA Kits) to accomplish internucleosomal DNA fragmentation .

  7. Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor (show DFFA ELISA Kits) 40

  8. During apoptotic rearrangement of interchromatin granule clusters, the nuclear matrix (NuMa (show NUMA1 ELISA Kits) rearrangement) and chromatin are closely associated. This process occurs in defined stages and depends on the activity of protein phosphatases, caspases and CAD (show CAD ELISA Kits).

  9. the cytosolic levels of DFF40/CAD are determinants in achieving a complete apoptotic phenotype, including oligonucleosomal DNA degradation.

  10. Data show that among the 13 SNPs in the 3 genes, only 3 were found to be polymorphic: R196K and K277R in the DFFB gene, and S12L in the EndoG (show ENDOG ELISA Kits) gene, and all 6 SNPs in the FEN-1 (show FEN1 ELISA Kits) gene were entirely monoallelic.

Mouse (Murine) DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) interaction partners

  1. the highest order of chromatin compaction observed in the later steps of caspase (show CASP3 ELISA Kits)-dependent apoptosis relies on DFF40/CAD-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks

  2. results show that caspase 3 (show CASP3 ELISA Kits)/CAD (show CAD ELISA Kits) promotes cell differentiation by directly modifying the DNA/nuclear microenvironment, which enhances the expression of critical regulatory genes

  3. Co-transfection of mouse DFF45 (show DFFA ELISA Kits)(-/-) fibroblasts with plasmids encoding human DFF40 and DFF45 (show DFFA ELISA Kits) reversed the apoptosis resistance normally observed in these cells

  4. The thymus of DNase II(-/-)CAD (show CAD ELISA Kits)(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development.

  5. Interactions identified here between mouse liver histone H1 (show H1F0 ELISA Kits) carboxyl-terminal domain and DFF40/CAD target and activate linker DNA cleavage during the terminal stages of apoptosis.

  6. The results suggest that CAD protein (show CAD ELISA Kits) may be preferentially degraded by the ubiquitin-proteasome system in the absence of its inhibitor (ICAD (show DFFA ELISA Kits)) to maintain protein quality control.

  7. A los of caspase-activated DNASE enhances tumorigenesis induced by a chemical carcinogen in a model of skin carcinogenesis in mice.

DFFB Antigen Profile

Antigen Summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined.

Alternative names and synonyms associated with DFFB

  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB) Elisa Kit
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (LOC100223514) Elisa Kit
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (Dffb) Elisa Kit
  • DNA fragmentation factor, beta subunit (Dffb) Elisa Kit
  • 40kDa Elisa Kit
  • 5730477D02Rik Elisa Kit
  • Cad Elisa Kit
  • CPAN Elisa Kit
  • DFF-40 Elisa Kit
  • DFF2 Elisa Kit
  • DFF40 Elisa Kit
  • Didff Elisa Kit
  • LOC100223514 Elisa Kit

Protein level used designations for DFFB

DNA fragmentation factor subunit beta , DNA fragmentation factor, 40 kD, beta polypeptide , DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor 40 kDa subunit , caspase-activated DNase , caspase-activated deoxyribonuclease , caspase-activated nuclease , DFF-40 , DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, beta polypeptide (caspase-activated DNase) , DNA fragmentation factor, beta subunit , DNA fragmentation factor, 40 kD, beta subunit , DNase inhibited by DNA fragmentation factor

GENE ID SPECIES
374158 Gallus gallus
744932 Pan troglodytes
100223514 Taeniopygia guttata
1677 Homo sapiens
84359 Rattus norvegicus
100713108 Cavia porcellus
512730 Bos taurus
489623 Canis lupus familiaris
13368 Mus musculus
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