anti-Rat (Rattus) Endonuclease G antibody for Enzyme Immunoassay

Recommended Endonuclease G Antibody (supplied by: Log in to see )

Antigen
Endonuclease G (ENDOG) Antibodies
  • CG8862
  • Dmel\\CG8862
  • Tb08.10J17.140
  • Tb08.10J17.90
  • TBC1D13
  • endog
  • ENDOG
  • wu:fb79c08
  • zgc:110020
  • Endonuclease G
  • endonuclease G
  • endonuclease G, mitochondrial
  • endonuclease G, mitochondrial-like
  • EndoG
  • Tc00.1047053506867.10
  • Tb927.8.4040
  • Tb927.8.4090
  • LbrM10_V2.0750
  • LmjF10.0610
  • NAEGRDRAFT_78507
  • ENDOG
  • endog
  • eNDOG
  • LOC100410999
  • Endog
Reactivity
Human, Mouse (Murine), Rat (Rattus)
97
67
64
5
2
2
2
1
1
1
1
1
1
Host
Rabbit
74
27
Clonality
Polyclonal
Conjugate
This Endonuclease G antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
78
29
19
19
13
8
5
5
4
2
2
1
Supplier
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Catalog No. ABIN5554776
$ 375.38
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5551034 EIA WB Mouse IgG AA 51-140 Log in to see 7G1C10
1 ABIN5551037 EIA WB Mouse IgG AA 51-140 Log in to see 7F2G10
1 ABIN5551036 EIA WB Mouse IgG AA 51-140 Log in to see 7F2D7

General

Antigen Endonuclease G (ENDOG) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(97), (67), (64), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(74), (27)
Clonality
Polyclonal
Conjugate This Endonuclease G antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(78), (29), (19), (19), (13), (8), (5), (5), (4), (2), (2), (1)
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Product Details anti-Endonuclease G Antibody

Target Details Endonuclease G Application Details Handling Images
Specificity EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.
Purification Affinity chromatography purified via peptide column
Immunogen Human EndoG Peptide
Isotype IgG

Target Details Endonuclease G

Product Details anti-Endonuclease G Antibody Application Details Handling Images back to top
Antigen
Alternative Name Endonuclease G (ENDOG Antibody Abstract)
Background The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndooG also cleaves DNA in vitro (4).Synonyms: ENDOG
Gene ID 2021
NCBI Accession NP_004426
UniProt Q14249
Research Area DNA/RNA
Pathways Apoptosis

Application Details

Product Details anti-Endonuclease G Antibody Target Details Endonuclease G Handling Images back to top
Application Notes ELISA. Western 1 to 2 μg/mL. HepG2 and 3T3 cell lysates can be used as positive control and a 35 kDa band can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Endonuclease G Antibody Target Details Endonuclease G Application Details Images back to top
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.