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anti-Rat (Rattus) FADD antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended FADD Antibody (supplied by: Log in to see )

Antigen
Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies
  • MORT1
  • Mort1/FADD
  • Mort1
  • TNFRSF6
  • Fas (TNFRSF6)-associated via death domain
  • FADD
  • Fadd
Epitope
pSer194
30
27
25
20
19
17
14
9
7
6
5
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
212
78
37
11
3
2
Host
Rabbit
167
96
Clonality
Polyclonal
Conjugate
This FADD antibody is conjugated to HRP
11
10
8
7
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
232
144
87
39
29
15
15
7
5
4
4
3
1
1
Options
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Catalog No. ABIN675333
$ 427.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN675326 IHC (p) WB Biotin Rabbit IgG pSer194 Log in to see Polyclonal
1 ABIN675324 IF (p) IHC (p) WB Rabbit IgG pSer194 Log in to see Polyclonal

Similar anti-FADD Antibodies

Application / Reactivity Rat (Rattus)
ELISA 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 10 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Immunoprecipitation (IP) 10 Antibodies
Western Blotting (WB) 24 Antibodies

General

Antigen Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies
Epitope pSer194
(30), (27), (25), (20), (19), (17), (14), (9), (7), (6), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Rat (Rattus)
(212), (78), (37), (11), (3), (2)
Host Rabbit
(167), (96)
Clonality
Polyclonal
Conjugate This FADD antibody is conjugated to HRP
(11), (10), (8), (7), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(232), (144), (87), (39), (29), (15), (15), (7), (5), (4), (4), (3), (1), (1)
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Product Details anti-FADD Antibody

Target Details FADD Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from rat protein FADD around the phosphorylation site of Ser194
Isotype IgG

Target Details FADD

Product Details anti-FADD Antibody Application Details Handling Images back to top
Antigen
Alternative Name Fadd (FADD Antibody Abstract)
Background

FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.


Synonyms: FADD phospho S194, p-FADD phospho S194, P-Fas-associated protein with death domain, FADD protein, Fas TNFRSF6 associated via death domain, Fas associated via death domain, Fas associating death domain containing protein, Fas associating protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, GIG 3, GIG3, Growth inhibiting gene 3 protein, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity , MGC8528 , MORT 1, MORT1.
Gene ID 266610
Research Area Cancer, Apoptosis/Necrosis
Pathways Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades

Application Details

Product Details anti-FADD Antibody Target Details FADD Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only

Handling

Product Details anti-FADD Antibody Target Details FADD Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Preservative Gentamicin sulfate
Precaution of Use This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Storage -20 °C
Storage Comment Store at 4°C
Expiry Date 12 months