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anti-Human FASL antibody for Mass Cytometry

Recommended FASL Antibody (supplied by: Log in to see )

Antigen
Fas Ligand (TNF Superfamily, Member 6) (FASL) Antibodies
  • ALPS1B
  • APT1LG1
  • Apt1Lg1
  • APTL
  • CD95-L
  • CD95L
  • CD178
  • FAS
  • Fas-L
  • FASL
  • fasl
  • Fasl
  • Faslg
  • FASLG
  • gld
  • TNFRSF6
  • Tnfsf6
  • TNFSF6
  • zgc:162027
Reactivity
Human
274
138
65
3
3
1
1
1
1
1
Host
Mouse
146
126
61
29
12
6
Clonality
Monoclonal
Conjugate
This FASL antibody is conjugated to PE
32
25
18
5
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
196
162
87
63
57
50
30
29
17
12
11
11
11
6
3
2
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN2663099
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008696036 ABIN2663100 FACS CyTOF PE Mouse IgG1 kappa Log in to see NOK-1 8

Top referenced anti-FASL antibody for Mass Cytometry

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Application / Reactivity Human
Blocking Antibody (Inhibition) 2 Antibodies
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Cellular Assay (CA) 1 Antibodies
Dot Blot (DB) 1 Antibodies
ELISA 82 Antibodies
ELISA (Capture) 1 Antibodies
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Enzyme Immunoassay (EIA) 11 Antibodies
Flow Cytometry (FACS) 120 Antibodies
Functional Studies (Func) 23 Antibodies
Immunoassay (IA) 1 Antibodies
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Immunofluorescence (IF) 16 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 40 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 8 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 66 Antibodies

General

Antigen Fas Ligand (TNF Superfamily, Member 6) (FASL) Antibodies
Reactivity Human
(274), (138), (65), (3), (3), (1), (1), (1), (1), (1)
Host Mouse
(146), (126), (61), (29), (12), (6)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FASL antibody is conjugated to PE
(32), (25), (18), (5), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(196), (162), (87), (63), (57), (50), (30), (29), (17), (12), (11), (11), (11), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-FASL Antibody

Target Details FASL Application Details Handling References for anti-FASL Antibody (ABIN2663099) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone NOK-1
Isotype IgG1 kappa

Target Details FASL

Product Details anti-FASL Antibody Application Details Handling References for anti-FASL Antibody (ABIN2663099) Images back to top
Antigen
Alternative Name CD178 (FASL Antibody Abstract)
Background CD178 is a 38-42 kD type II glycoprotein also known as Fas ligand and CD95L. CD178 belongs to the TNF superfamily and is expressed on activated T lymphocytes, NK cells, monocytes, and granulocytes. CD178 is also expressed on parenchymal cells of the retina and cornea, retinal pigment epithelial cells, and testis. The extracellular region of FasL can be cleaved by matrix metalloproteinases (MMPs) to give rise to a 26 kD soluble protein. CD178 binds to CD95, a member of the TNFR superfamily, to induce apoptosis. CD95/CD95L interactions play an important role in the maintenance of peripheral tolerance and survival.
Pathways Apoptosis, EGFR Signaling Pathway

Application Details

Product Details anti-FASL Antibody Target Details FASL Handling References for anti-FASL Antibody (ABIN2663099) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FASL Antibody Target Details FASL Application Details References for anti-FASL Antibody (ABIN2663099) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-FASL Antibody (ABIN2663099)

Product Details anti-FASL Antibody Target Details FASL Application Details Handling Images back to top
Background publications

Li, DAlessio, Pober: "Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells." in: The American journal of pathology, Vol. 175, Issue 3, pp. 1124-35, 2009

Strauss, Bergmann, Whiteside: "Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 3, pp. 1469-80, 2009

Andreola, Rivoltini, Castelli, Huber, Perego, Deho, Squarcina, Accornero, Lozupone, Lugini, Stringaro, Molinari, Arancia, Gentile, Parmiani, Fais: "Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles." in: The Journal of experimental medicine, Vol. 195, Issue 10, pp. 1303-16, 2002

Herr, Posovsky, Böhler, Debatin: "mAb33 from transduction laboratories specifically binds human CD95-L." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 129-30, 2000

Bossi, Griffiths: "Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells." in: Nature medicine, Vol. 5, Issue 1, pp. 90-6, 1999

Kayagaki, Kawasaki, Ebata, Ohmoto, Ikeda, Inoue, Yoshino, Okumura, Yagita: "Metalloproteinase-mediated release of human Fas ligand." in: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1777-83, 1996

Tanaka, Suda, Takahashi, Nagata: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, 1995

Images

Product Details anti-FASL Antibody Target Details FASL Application Details Handling References for anti-FASL Antibody (ABIN2663099) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-FASL antibody (Fas Ligand (TNF Superfamily, Member 6))  (PE) (ABIN2663099) anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody (PE)