Fas ligand (FasL or CD95L) is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptoic signal into cells. FasL is involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis has a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells or both. Defects in FasL are the cause of autoimmune lymphoproliferative syndrome 1B (ALPS1B), a childhood syndrome involving hemolytic anemia and thrombocytopenia.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4 with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.