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anti-Human GZMA antibody for Flow Cytometry

Recommended GZMA Antibody (supplied by: Log in to see )

Antigen
Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Antibodies
  • AW494114
  • Ctla-3
  • Ctla3
  • CTLA3
  • gzmA
  • GZMA
  • Hf
  • HFSP
  • SE1
  • TSP-1
  • TSP1
Reactivity
Human
106
32
17
1
1
1
Host
Mouse
58
49
14
Clonality
Monoclonal
Conjugate
This GZMA antibody is conjugated to Pacific Blue
7
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
48
34
30
23
19
11
6
5
4
4
3
2
1
1
1
Supplier
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Catalog No. ABIN2662333
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.3037917 ABIN2658092 FACS IF CyTOF Alexa Fluor 700 Mouse IgG1 kappa Log in to see CB9 9
0.3037917 ABIN2656845 FACS Alexa Fluor 594 Mouse IgG1 kappa Log in to see CB9 8
0.3037917 ABIN2657504 FACS Alexa Fluor 488 Mouse IgG1 kappa Log in to see CB9 9
0.3037917 ABIN2657898 FACS Alexa Fluor 647 Mouse IgG1 kappa Log in to see CB9 8
0.3037917 ABIN2661889 FACS FITC Mouse IgG1 kappa Log in to see CB9 9
0.3037917 ABIN2660430 FACS PerCP-Cy5.5 Mouse IgG1 kappa Log in to see CB9 10
0.3037917 ABIN2663713 FACS PE Mouse IgG1 kappa Log in to see CB9 8
0.3037917 ABIN2665014 FACS Mouse IgG1 kappa Log in to see CB9 8
0.3037917 ABIN2679989 FACS ICS PE-Cy7 Mouse IgG1 kappa Log in to see CB9
0.3037917 ABIN2679991 FACS ICS EFluor 660 Mouse IgG1 kappa Log in to see CB9
0.0010485103 ABIN205475 FACS IHC (p) IP WB Mouse IgG1 Log in to see CB9
0.0010485103 ABIN2662334 FACS Pacific Blue Mouse IgG1 kappa Log in to see CB9 12
0.0010485103 ABIN2660431 FACS PerCP-Cy5.5 Mouse IgG1 kappa Log in to see CB9 10
0.0010485103 ABIN4316053 FACS Alexa Fluor 488 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316054 FACS Alexa Fluor 700 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316055 FACS Alexa Fluor 647 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316056 FACS Alexa Fluor 750 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316057 FACS Alexa Fluor 594 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316058 FACS Alexa Fluor 350 Mouse IgG2b AA 26-262 Log in to see 356412
0.0010485103 ABIN4316059 FACS Alexa Fluor 405 Mouse IgG2b AA 26-262 Log in to see 356412

Top referenced anti-GZMA antibody for Flow Cytometry

Similar anti-GZMA Antibodies

Application / Reactivity Human
ELISA 29 Antibodies
ELISA (Capture) 1 Antibodies
Flow Cytometry (FACS) 24 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 5 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 22 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 19 Antibodies
Immunoprecipitation (IP) 4 Antibodies
Intracellular Staining (ICS) 2 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 45 Antibodies

General

Antigen Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Antibodies
Reactivity Human
(106), (32), (17), (1), (1), (1)
Host Mouse
(58), (49), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This GZMA antibody is conjugated to Pacific Blue
(7), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(48), (34), (30), (23), (19), (11), (6), (5), (4), (4), (3), (2), (1), (1), (1)
Pubmed 12 references available
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Product Details anti-GZMA Antibody

Target Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2662333) Images
Purification The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.
Clone CB9
Isotype IgG1 kappa

Target Details GZMA

Product Details anti-GZMA Antibody Application Details Handling References for anti-GZMA Antibody (ABIN2662333) Images back to top
Antigen
Alternative Name Granzyme A (GZMA Antibody Abstract)
Background Granzyme A is a 28 kD disulfide-linked homodimeric protein and the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme B is thought to be a rapidly-acting apoptotic enzyme, while Granzyme A is slow acting. The CB9 monoclonal antibody recognizes human Granzyme A and has been shown to be useful for flow cytometry, immunoprecipitation, and immunohistochemistry (paraffin-embedded sections).
Research Area Immunology, Innate Immunity, Adaptive Immunity, Apoptosis/Necrosis, Cell/Tissue Markers
Pathways Apoptosis

Application Details

Product Details anti-GZMA Antibody Target Details GZMA Handling References for anti-GZMA Antibody (ABIN2662333) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-GZMA Antibody Target Details GZMA Application Details References for anti-GZMA Antibody (ABIN2662333) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-GZMA Antibody (ABIN2662333)

Product Details anti-GZMA Antibody Target Details GZMA Application Details Handling Images back to top
Background publications

Dimova, Brouwer, Gosselin, Tassignon, Leo, Donner, Marchant, Vermijlen: "Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 6, pp. E556-65, 2015

Marquardt, Béziat, Nyström, Hengst, Ivarsson, Kekäläinen, Johansson, Mjösberg, Westgren, Lankisch, Wedemeyer, Ellis, Ljunggren, Michaëlsson, Björkström: "Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 6, pp. 2467-71, 2015

Yamamoto, Johnson, Price, Wolinsky, Almeida, Petrovas, Nason, Yeh, Shen, Roederer, Rao, McDermott, Lefebvre, Nabel, Haddad, Letvin, Douek, Koup: "Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection." in: Journal of virology, Vol. 86, Issue 10, pp. 5877-84, 2012

Cellerai, Perreau, Rozot, Bellutti Enders, Pantaleo, Harari: "Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression." in: Journal of virology, Vol. 84, Issue 8, pp. 3868-78, 2010

Chen, Hou, Jiang, Ma, Meng, Wang, Zhang, Zhang, Tang, Zhang, Wan, Li, Yu, Hu, Yang, He, Wang, Cao: "Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 1, pp. 591-8, 2005

Fan, Beresford, Oh, Zhang, Lieberman: "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor." in: Cell, Vol. 112, Issue 5, pp. 659-72, 2003

Fan, Beresford, Zhang, Xu, Novina, Yoshida, Pommier, Lieberman: "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A." in: Nature immunology, Vol. 4, Issue 2, pp. 145-53, 2003

Raqib, Ekberg, Sharkar, Bardhan, Zychlinsky, Sansonetti, Andersson: "Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2." in: Infection and immunity, Vol. 70, Issue 6, pp. 3199-207, 2002

Trimble, Lieberman: "Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex." in: Blood, Vol. 91, Issue 2, pp. 585-94, 1998

Beresford, Kam, Powers, Lieberman: "Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9285-90, 1997

Masson, Tschopp: "A family of serine esterases in lytic granules of cytolytic T lymphocytes." in: Cell, Vol. 49, Issue 5, pp. 679-85, 1987

Brunet, Dosseto, Denizot, Mattei, Clark, Haqqi, Ferrier, Nabholz, Schmitt-Verhulst, Luciani, Golstein: "The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14." in: Nature, Vol. 322, Issue 6076, pp. 268-71, 1986

Images

Product Details anti-GZMA Antibody Target Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2662333) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-GZMA antibody (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3))  (Pacific Blue) (ABIN2662333) anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibody (Pacific Blue)