Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Differential proteomics were used to identify granzyme B substrates in three unrelated bacteria: Escherichia coli, Listeria monocytogenes, and Mycobacteria tuberculosis. Granzyme B cleaves a highly conserved set of proteins in all three bacteria, which function in vital biosynthetic and metabolic pathways that are critical for bacterial survival under diverse environmental conditions.
this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Released granzyme B induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin
serglycin plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B, whereas granzyme A is unaffected
these results suggest a perforin-independent, extracellular role for GzmB in the pathogenesis of cardiac fibrosis
data indicate an involvement of granzyme B in the neuroinflammation mediated by Eomes(+) CD4(+) T cells.
Data suggest that targeting granzyme B (GzmB) in selected T cell subsets may provide a strategy to control graft-versus-host disease (GVHD).
We conclude that GzmbCre can be used under some conditions to investigate gene function in mature and activated natural killer cells.
These findings indicate a significant role for GzmB in extracellular matrix degradation that may have implications in many age-related chronic inflammatory diseases.
Different natural variants of granzyme B have a profound impact on the immune response to a common and authentic viral pathogen.
Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.
The mitochondrial apoptotic pathway activated via Bim is critically involved in apoptosis induced by mouse granzyme B.
The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.
expedites cytotoxic T-lymphocyte diapedesis via basement membrane remodeling
CD4(+) natural killer cells potently promote atherosclerosis by granzyme B (and perforin)-dependent apoptosis.
Granzyme B has a role in atherosclerotic plaque development.
Data indicate that all-trans retinoic acid (ATRA), which induces miR-23a expression, decreases cathepsin C (CTSC) expression and granzyme B activity leading to impaired NK cell cytotoxicity.
Data indicate a distinct pattern of caspase activation induced by granzyme B versus Fas in cytotoxic T-Lymphocytes (CTL).
Data indicate that vascular permeability is reduced in Granzyme B (GZMB)-KO mice after delayed-type hypersensitivity -induced inflammation.
GzmB is a negative regulator of hematopoietic stem cell function that is induced by stress and chemotherapy in both HSCs and their niches.
Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 epitopes in rheumatoid arthritis.
our results suggest granzyme B PET imaging can serve as a quantitatively useful predictive biomarker for efficacious responses to cancer immunotherapy.
Plasma GzmB levels may reflect the degree of pruritus and dermatitis in patients with atopic dermatitis
These results suggest the critical importance of miR-378 in the regulation of GrzB expression and a protective role for GrzB in controlling dengue virus replication in vivo.
Analysis of infiltrating granzyme B-expressing T cells at the invasive borders of the colon tumors revealed a significant difference in expression granzyme by race underlining decreased antitumor cytotoxic immunity in African Americans.
Increased TIM3+CD8+T cells with lower perforin and granzyme B expression and higher CD95 expression in MDS patients were observed.
Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells.
granzyme-B levels were found to be significantly associated with increased insulin resistance in adolescent polycystic ovary syndrome patients. Additionally, elevated levels of serum granzyme-B were predictive for increased cardiovascular risk in PCOS patients
results suggest that enhanced IL-21R expression of CD19(+)CD5(+) B cells and production of IL-21 by iNKT cells may play an important role in the pathogenesis of pSS by regulating CD19(+)CD5(+) B cell functions and increasing GrB production, presumably leading to a counter-regulatory effect in the disease.
Findings show that GrB was produced in 57.1% colorectal cancer cell (CRC) lines and 100% CRC-derived Cancer Stem Cells and present a novel role for GrB as up-modulator of epitelial-to-mesenchimal transition in CRC cells.
FASL, granzyme B, and cytochrome c blood expression reflects breast cancer progression and response to therapy. (Review)
Data show that NK cell lines could secreted rapidly inactive Mr 35 000 granzyme B (GZB)outside secretory lysosomes (SLs).
Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9.
Delivered into parasite infected cells by granulysin and perforin, granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.
Among SLAMF4+ cells, the T cell fraction positive for perforin and granzyme B was higher in those obtained from healthy donors, while the percentage of T cells that were single-positive for granzyme B was higher in cells obtained from patients with SLE.
Costimulation blockade by abatacept can decrease the serum levels of GZMB in rheumatoid arthritis patients responding to the treatment.
elevated in the inflammatory lesions of placentas with villitis of unknown etiology
It is a cytotoxic genes in the endometrium and hightly expressed in the peri-implantation endometrium.
Duodenase interacted with P1 variants of antichymotrypsin via a suicide mechanism with stoichiometry of the process SI = 1.2.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
, cytotoxic cell protease 1
, granzyme B(G,H)
, T-cell serine protease 1-3E
, cathepsin G-like 1
, cytotoxic T-lymphocyte proteinase 2
, cytotoxic serine protease B
, fragmentin 2
, human lymphocyte protein
, GLP I
, GLP III
, granzyme-like protein 1
, granzyme-like protein I
, natural killer cell protease 1
, granzyme H
, duodenase I
, duodenum serine protease