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this study shows that gzmA (show GZMA Antibodies) and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Released granzyme B induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin (show PRF1 Antibodies)
serglycin (show SRGN Antibodies) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin (show PRF1 Antibodies) and granzyme B, whereas granzyme A (show GZMA Antibodies) is unaffected
these results suggest a perforin (show PRF1 Antibodies)-independent, extracellular role for GzmB in the pathogenesis of cardiac fibrosis
data indicate an involvement of granzyme B in the neuroinflammation mediated by Eomes (show EOMES Antibodies)(+) CD4 (show CD4 Antibodies)(+) T cells.
Data suggest that targeting granzyme B (GzmB) in selected T cell subsets may provide a strategy to control graft-versus-host disease (GVHD).
These findings indicate a significant role for GzmB in extracellular matrix degradation that may have implications in many age-related chronic inflammatory diseases.
Different natural variants of granzyme B have a profound impact on the immune response to a common and authentic viral pathogen.
Visualization of granzyme B-expressing CD8 (show CD8A Antibodies) T cells during primary and secondary immune responses to Listeria monocytogenes.
The mitochondrial apoptotic pathway activated via Bim (show BCL2L11 Antibodies) is critically involved in apoptosis induced by mouse granzyme B.
Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 (show PADI4 Antibodies) epitopes in rheumatoid arthritis.
our results suggest granzyme B PET imaging can serve as a quantitatively useful predictive biomarker for efficacious responses to cancer immunotherapy.
Plasma GzmB levels may reflect the degree of pruritus and dermatitis in patients with atopic dermatitis
These results suggest the critical importance of miR (show MLXIP Antibodies)-378 in the regulation of GrzB expression and a protective role for GrzB in controlling dengue virus replication in vivo.
Analysis of infiltrating granzyme B-expressing T cells at the invasive borders of the colon tumors revealed a significant difference in expression granzyme by race underlining decreased antitumor cytotoxic immunity in African Americans.
Increased TIM3 (show HAVCR2 Antibodies)+CD8 (show CD8A Antibodies)+T cells with lower perforin (show PRF1 Antibodies) and granzyme B expression and higher CD95 (show FAS Antibodies) expression in MDS (show PAFAH1B1 Antibodies) patients were observed.
Carbamate pesticides significantly reduced the intracellular levels of perforin (show PRF1 Antibodies), GrA (show NR3C1 Antibodies), GrB, Gr3 (show PRLHR Antibodies)/K, and GRN (show GRN Antibodies) in NK-92CI cells.
granzyme-B levels were found to be significantly associated with increased insulin (show INS Antibodies) resistance in adolescent polycystic ovary syndrome patients. Additionally, elevated levels of serum granzyme-B were predictive for increased cardiovascular risk in PCOS patients
results suggest that enhanced IL-21R (show IL21R Antibodies) expression of CD19 (show CD19 Antibodies)(+)CD5 (show CD5 Antibodies)(+) B cells and production of IL-21 (show IL17C Antibodies) by iNKT cells may play an important role in the pathogenesis of pSS (show CDSN Antibodies) by regulating CD19 (show CD19 Antibodies)(+)CD5 (show CD5 Antibodies)(+) B cell functions and increasing GrB production, presumably leading to a counter-regulatory effect in the disease.
Findings show that GrB was produced in 57.1% colorectal cancer cell (CRC (show CALR Antibodies)) lines and 100% CRC (show CALR Antibodies)-derived Cancer Stem Cells and present a novel role for GrB as up-modulator of epitelial-to-mesenchimal transition in CRC (show CALR Antibodies) cells.
It is a cytotoxic genes in the endometrium and hightly expressed in the peri (show PLIN1 Antibodies)-implantation endometrium.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
, cytotoxic cell protease 1
, granzyme B(G,H)
, T-cell serine protease 1-3E
, cathepsin G-like 1
, cytotoxic T-lymphocyte proteinase 2
, cytotoxic serine protease B
, fragmentin 2
, human lymphocyte protein
, GLP I
, GLP III
, granzyme-like protein 1
, granzyme-like protein I
, natural killer cell protease 1
, granzyme H
, duodenase I
, duodenum serine protease