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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)||Cow (Bovine)|
|Immunofluorescence (fixed cells) (IF/ICC)||9 Antibodies||7 Antibodies||7 Antibodies||2 Antibodies|
|Cytometry by Time of Flight (CyTOF)||2 Antibodies||2 Antibodies||2 Antibodies||2 Antibodies|
|Western Blotting (WB)||218 Antibodies||202 Antibodies||338 Antibodies||97 Antibodies|
|Immunoprecipitation (IP)||47 Antibodies||20 Antibodies||16 Antibodies||9 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies|
|Antigen||Lamin A/C (LMNA) Antibodies|
|Epitope||AA 59-249 Alternatives|
|Reactivity||Cow (Bovine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Lamin A/C antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-Lamin A/C AntibodyTarget Details Lamin A/C Application Details Handling Images
|Specificity||Recognizes Lamin A/C.|
Species reactivity (expected):Mouse (98 %), Rat (98 %), Bovine (98 %).
Species reactivity (tested):Human.
|Immunogen||Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 249 of Lamin A/C|
Target Details Lamin A/CProduct Details anti-Lamin A/C Antibody Application Details Handling Images back to top
|Alternative Name||Lamin-A/C (LMNA) (LMNA Antibody Abstract)|
|Background||Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. Lamin A, Lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. Lamin B1 and Lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32|
|Gene ID||4000, 9606|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus|
Application DetailsProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling Images back to top
Western blotting: 1/500-1/3000. Positive Controls: HeLa, HeLa NucleusImmunohistochemistry on Paraffin Sections: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Images back to top
|Buffer||0.1 M Tris, 0.1 M Glycine, 10 % Glycerol and 0.01 % Thimerosal as preservative.|
|Precaution of Use||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store the antibody undiluted (in aliquots) at -20 °C.|
ImagesProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling back to top