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anti-Mammalian Lamin A/C antibody for Western Blotting

Recommended Lamin A/C Antibody (supplied by: Log in to see )

Antigen
Lamin A/C (LMNA) Antibodies
  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • Dhe
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • lmna-A
  • lamin-L(III)-like
  • Lamin
  • lamin A
  • lamin A/C
  • lamin B3
  • Lam
  • lmna
  • LMNA
  • lmnb3
  • Lmna
Reactivity
Human, Cow (Bovine), Pig (Porcine), Mouse (Murine), Rat (Rattus), Mammalian
391
264
244
102
53
51
22
19
15
10
8
7
5
5
3
2
2
1
1
1
Host
Mouse
220
171
5
1
Clonality
Monoclonal
Conjugate
This Lamin A/C antibody is un-conjugated
10
8
8
6
6
6
4
4
4
4
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
349
162
125
124
104
76
64
59
47
27
11
8
2
2
2
1
1
Supplier
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Catalog No. ABIN1580429
$ 220.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
3.0877867 ABIN1580428 ICC IF IHC WB Chicken IgY Log in to see Polyclonal 2
1 ABIN1580430 ICC IF IHC WB Rabbit Log in to see Polyclonal

Top referenced anti-Lamin A/C antibody for Western Blotting

Similar anti-Lamin A/C Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Pig (Porcine) Cow (Bovine) Mammalian
Immunofluorescence (fixed cells) (IF/ICC) 8 Antibodies 7 Antibodies 7 Antibodies 3 Antibodies 2 Antibodies
Cytometry by Time of Flight (CyTOF) 2 Antibodies 2 Antibodies 2 Antibodies 2 Antibodies
Western Blotting (WB) 225 Antibodies 208 Antibodies 344 Antibodies 97 Antibodies 50 Antibodies 3 Antibodies
Immunoprecipitation (IP) 47 Antibodies 20 Antibodies 16 Antibodies

General

Antigen Lamin A/C (LMNA) Antibodies
Reactivity Human, Cow (Bovine), Pig (Porcine), Mouse (Murine), Rat (Rattus), Mammalian
(391), (264), (244), (102), (53), (51), (22), (19), (15), (10), (8), (7), (5), (5), (3), (2), (2), (1), (1), (1)
Host Mouse
(220), (171), (5), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Lamin A/C antibody is un-conjugated
(10), (8), (8), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(349), (162), (125), (124), (104), (76), (64), (59), (47), (27), (11), (8), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-Lamin A/C Antibody

Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C Antibody (ABIN1580429) Images
Purification affinity purified antibody
Clone 4C4
Isotype IgG1

Target Details Lamin A/C

Product Details anti-Lamin A/C Antibody Application Details Handling References for anti-Lamin A/C Antibody (ABIN1580429) Images back to top
Antigen
Alternative Name Lamin A/C (LMNA Antibody Abstract)
Background Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm. Lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene, while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74 kDa while Lamin C is 65 kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of maturation promoting factor, the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of Lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging. The HGNC name for this protein is LMNA.
Research Area Cytoskeleton, Extracellular Matrix
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling References for anti-Lamin A/C Antibody (ABIN1580429) Images back to top
Application Notes The antibody solution can be used at dilutions of at least 1:1,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:10,000 or lower.
Restrictions For Research Use only

Handling

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details References for anti-Lamin A/C Antibody (ABIN1580429) Images back to top
Format Liquid
Concentration 1 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 4°C short term or -20°C long term.

References for anti-Lamin A/C Antibody (ABIN1580429)

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling Images back to top
Background publications

Liu, Zhou: "Lamin A/C, laminopathies and premature ageing." in: Histology and histopathology, Vol. 23, Issue 6, pp. 747-63, 2008

Fisher, Chaudhary, Blobel: "cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 17, pp. 6450-4, 1986

Images

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C Antibody (ABIN1580429) back to top
Supplier Images
Western Blotting (WB) image for anti-Lamin A/C antibody (LMNA) (ABIN1580429) Strip blots of crude HeLa cell extract stained with MCS-4C4. Note two strong clean ba...
Immunofluorescence (IF) image for anti-Lamin A/C antibody (LMNA) (ABIN1580429) HeLa cells staining with ABIN1580429 (red), and counterstained with ’s chicken polycl...